DE60221684D1 - Antibiotika mit doppelwirkung - Google Patents

Antibiotika mit doppelwirkung

Info

Publication number
DE60221684D1
DE60221684D1 DE60221684T DE60221684T DE60221684D1 DE 60221684 D1 DE60221684 D1 DE 60221684D1 DE 60221684 T DE60221684 T DE 60221684T DE 60221684 T DE60221684 T DE 60221684T DE 60221684 D1 DE60221684 D1 DE 60221684D1
Authority
DE
Germany
Prior art keywords
antibiotics
double effect
compounds
variety
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60221684T
Other languages
English (en)
Other versions
DE60221684T2 (de
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem AG fuer Kombinatorische Chemie
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Publication of DE60221684D1 publication Critical patent/DE60221684D1/de
Application granted granted Critical
Publication of DE60221684T2 publication Critical patent/DE60221684T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60221684T 2001-10-04 2002-10-04 Antibiotika mit doppelwirkung Expired - Lifetime DE60221684T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32716201P 2001-10-04 2001-10-04
US327162P 2001-10-04
PCT/EP2002/011163 WO2003032962A2 (en) 2001-10-04 2002-10-04 Dual action antibiotics

Publications (2)

Publication Number Publication Date
DE60221684D1 true DE60221684D1 (de) 2007-09-20
DE60221684T2 DE60221684T2 (de) 2008-04-30

Family

ID=23275422

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60221684T Expired - Lifetime DE60221684T2 (de) 2001-10-04 2002-10-04 Antibiotika mit doppelwirkung

Country Status (21)

Country Link
US (2) US7820823B2 (de)
EP (1) EP1432705B1 (de)
JP (2) JP4398245B2 (de)
KR (2) KR100927864B1 (de)
CN (2) CN101381365B (de)
AT (1) ATE369363T1 (de)
AU (1) AU2002361948B2 (de)
BR (1) BRPI0213063B8 (de)
CA (1) CA2460572C (de)
CY (1) CY1107503T1 (de)
DE (1) DE60221684T2 (de)
DK (1) DK1432705T3 (de)
ES (1) ES2287354T3 (de)
HK (1) HK1128469A1 (de)
HU (1) HU229935B1 (de)
IL (2) IL160769A0 (de)
NZ (1) NZ531879A (de)
PL (1) PL210850B1 (de)
PT (1) PT1432705E (de)
WO (2) WO2003031443A1 (de)
ZA (1) ZA200401909B (de)

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WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
JP4805139B2 (ja) * 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
WO2004101552A1 (en) * 2003-05-14 2004-11-25 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
RU2371443C2 (ru) 2003-12-18 2009-10-27 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Оксазолидинон-хинолонгибридные антибиотики
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (de) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinon-Chinolon Hybrid Antibiotika
WO2005111030A1 (en) * 2004-05-12 2005-11-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
US8129411B2 (en) 2005-12-30 2012-03-06 Novartis Ag Organic compounds
US7456279B2 (en) * 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
EP2181993A1 (de) * 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimikrobielle Oxazolidinonderivate
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
BRPI0813900A2 (pt) 2007-06-25 2014-12-30 Novartis Ag Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina
AU2008317353B2 (en) * 2007-10-24 2014-08-07 Merck Sharp & Dohme Llc Heterocycle phenyl amide T-type calcium channel antagonists
KR101283222B1 (ko) * 2008-05-09 2013-07-11 액테리온 파마슈티칼 리미티드 세균성 장 질환 치료용 5-하이드록시메틸-옥사졸리딘-1-온 유도체
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
MX2015011948A (es) 2013-03-08 2015-12-09 Allergan Inc Antibioticos conjugados directamente relacionados con farmacos esteroides.
KR20150125663A (ko) 2013-03-08 2015-11-09 알러간, 인코포레이티드 사이클로스포린 a 스테로이드 켤레물
CN103145615B (zh) * 2013-03-20 2015-07-29 浙江医药股份有限公司 一种奈诺沙星螯合物的后处理方法
CN105338972A (zh) 2013-05-28 2016-02-17 莫弗凯姆联合化学股份公司 用于胃肠外治疗或预防细菌性疾病的噁唑烷酮-喹诺酮杂合物抗菌剂
WO2014191109A1 (en) 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
CN103421008B (zh) * 2013-09-07 2015-05-27 吉首大学 一类多靶点呋喃酮-喹啉酮型化合物及其制法和用途
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
CN107648181B (zh) * 2016-07-25 2021-05-04 广东赛法洛药业有限公司 一种利他唑酮磷脂复合物及其制备方法和应用
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN109942546B (zh) * 2019-04-16 2022-04-08 西南大学 喹诺酮嘧啶类化合物及其制备方法和应用
WO2023072794A1 (en) * 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Piperazinylsulfonylaryl compounds for treatment of bacterial infections

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GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
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WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
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US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
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DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) * 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
RU2371443C2 (ru) 2003-12-18 2009-10-27 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Оксазолидинон-хинолонгибридные антибиотики
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
MY148847A (en) 2006-11-10 2013-06-14 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
KR101283222B1 (ko) 2008-05-09 2013-07-11 액테리온 파마슈티칼 리미티드 세균성 장 질환 치료용 5-하이드록시메틸-옥사졸리딘-1-온 유도체

Also Published As

Publication number Publication date
HK1128469A1 (en) 2009-10-30
HU229935B1 (en) 2015-01-28
WO2003031443A1 (de) 2003-04-17
EP1432705B1 (de) 2007-08-08
JP4398245B2 (ja) 2010-01-13
DK1432705T3 (da) 2007-09-17
US20050096343A1 (en) 2005-05-05
ZA200401909B (en) 2005-05-25
PT1432705E (pt) 2007-08-27
BR0213063A (pt) 2004-09-28
CN101381365A (zh) 2009-03-11
ATE369363T1 (de) 2007-08-15
BRPI0213063B1 (pt) 2018-02-14
IL160769A0 (en) 2004-08-31
PL367517A1 (en) 2005-02-21
KR100927864B1 (ko) 2009-11-23
EP1432705A2 (de) 2004-06-30
IL160769A (en) 2009-12-24
WO2003032962A2 (en) 2003-04-24
KR100987696B1 (ko) 2010-10-13
US8329908B2 (en) 2012-12-11
JP2010006814A (ja) 2010-01-14
AU2002361948B2 (en) 2007-03-29
US7820823B2 (en) 2010-10-26
ES2287354T3 (es) 2007-12-16
BRPI0213063B8 (pt) 2021-05-25
CA2460572C (en) 2011-11-08
CA2460572A1 (en) 2003-04-24
US20110059946A1 (en) 2011-03-10
KR20040055781A (ko) 2004-06-26
JP2005529061A (ja) 2005-09-29
KR20090100426A (ko) 2009-09-23
HUP0402126A2 (hu) 2005-02-28
NZ531879A (en) 2005-10-28
CY1107503T1 (el) 2013-03-13
HUP0402126A3 (en) 2012-10-29
CN101381365B (zh) 2011-07-06
PL210850B1 (pl) 2012-03-30
DE60221684T2 (de) 2008-04-30
WO2003032962A3 (en) 2003-07-17
CN1630655A (zh) 2005-06-22

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