DE60218048T2 - Thiophenverbindungen als arzneimittel - Google Patents

Thiophenverbindungen als arzneimittel Download PDF

Info

Publication number
DE60218048T2
DE60218048T2 DE60218048T DE60218048T DE60218048T2 DE 60218048 T2 DE60218048 T2 DE 60218048T2 DE 60218048 T DE60218048 T DE 60218048T DE 60218048 T DE60218048 T DE 60218048T DE 60218048 T2 DE60218048 T2 DE 60218048T2
Authority
DE
Germany
Prior art keywords
formula
amino
aminocarbonyl
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218048T
Other languages
German (de)
English (en)
Other versions
DE60218048D1 (de
Inventor
c/o AstraZeneca R & D Alderley David Macclesfield GRIFFITHS
c/o AstraZeneca R & D Alderley Craig Macclesfield JOHNSTONE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60218048D1 publication Critical patent/DE60218048D1/de
Publication of DE60218048T2 publication Critical patent/DE60218048T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
DE60218048T 2001-07-25 2002-07-19 Thiophenverbindungen als arzneimittel Expired - Lifetime DE60218048T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102617 2001-07-25
SE0102617A SE0102617D0 (sv) 2001-07-25 2001-07-25 Novel compounds
PCT/SE2002/001402 WO2003010163A1 (en) 2001-07-25 2002-07-19 Novel compounds

Publications (2)

Publication Number Publication Date
DE60218048D1 DE60218048D1 (de) 2007-03-22
DE60218048T2 true DE60218048T2 (de) 2007-08-09

Family

ID=20284945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218048T Expired - Lifetime DE60218048T2 (de) 2001-07-25 2002-07-19 Thiophenverbindungen als arzneimittel

Country Status (17)

Country Link
US (1) US7098240B2 (cg-RX-API-DMAC7.html)
EP (1) EP1421079B1 (cg-RX-API-DMAC7.html)
JP (2) JP2004536869A (cg-RX-API-DMAC7.html)
KR (1) KR20040018521A (cg-RX-API-DMAC7.html)
CN (1) CN1538968A (cg-RX-API-DMAC7.html)
AT (1) ATE353327T1 (cg-RX-API-DMAC7.html)
BR (1) BR0211472A (cg-RX-API-DMAC7.html)
CA (1) CA2454702A1 (cg-RX-API-DMAC7.html)
DE (1) DE60218048T2 (cg-RX-API-DMAC7.html)
ES (1) ES2280559T3 (cg-RX-API-DMAC7.html)
IL (1) IL160023A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA04000755A (cg-RX-API-DMAC7.html)
NO (1) NO20040314L (cg-RX-API-DMAC7.html)
NZ (1) NZ530751A (cg-RX-API-DMAC7.html)
SE (1) SE0102617D0 (cg-RX-API-DMAC7.html)
WO (1) WO2003010163A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200400494B (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003154D0 (en) * 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
JP4544857B2 (ja) * 2001-06-11 2010-09-15 ヴァイロケム ファーマ インコーポレイテッド Ｆｌａｖｉｖｉｒｕｓ感染の治療または予防のための化合物および方法
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
ATE414697T1 (de) * 2001-10-04 2008-12-15 Smithkline Beecham Corp Nf-kb-inhibitoren
AU2003249683A1 (en) * 2002-06-06 2003-12-22 Smithkline Beecham Corporation Nf-:b inhibitors
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
SE0300092D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300091D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US7790724B2 (en) 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
WO2004096795A2 (en) * 2003-04-25 2004-11-11 3-Dimensional Pharmaceuticals, Inc. C-fms kinase inhibitors
US20050113566A1 (en) * 2003-04-25 2005-05-26 Player Mark R. Inhibitors of C-FMS kinase
US7427683B2 (en) * 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
EP2305671A1 (en) * 2004-01-05 2011-04-06 AstraZeneca AB Thiophene and thiazole derivatives as CHK1 inhibitors
PE20060373A1 (es) 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
EP2546246A3 (en) * 2005-05-13 2013-04-24 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
TWI380973B (zh) 2005-06-30 2013-01-01 Smithkline Beecham Corp 化合物
AU2007321677B2 (en) 2006-11-15 2013-04-11 Vertex Pharmaceuticals (Canada) Incorporated Thiophene analogues for the treatment or prevention of flavivirus infections
KR20090109551A (ko) * 2007-01-15 2009-10-20 산텐 세이야꾸 가부시키가이샤 ＩκＢ 키나아제 β 저해 활성을 갖는 신규 인돌 유도체
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
KR20160029870A (ko) 2008-04-21 2016-03-15 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
WO2010007972A1 (ja) * 2008-07-14 2010-01-21 参天製薬株式会社 カルバモイル基、ウレイド基及び置換オキシ基を有する新規インドール誘導体
CN102131774A (zh) * 2008-08-25 2011-07-20 参天制药株式会社 含有脲基、氨基羰基及可以具有取代基的二环式基团作为取代基的新型吡咯衍生物
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
EP2520292A1 (en) 2011-05-06 2012-11-07 Helmholtz-Zentrum für Infektionsforschung GmbH Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated disorders
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
CN107739370B (zh) * 2017-10-26 2021-03-30 中国药科大学 吡咯酮类brd4蛋白抑制剂的制备方法以及用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1468012A (en) 1973-08-09 1977-03-23 Beecham Group Ltd 2-amino-3-carboxy-thiophene derivatives
DE3529247A1 (de) 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung
EP0912548A1 (en) 1996-07-11 1999-05-06 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
PT853083E (pt) * 1997-01-06 2001-12-28 Pfizer Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica
US6809088B2 (en) * 1997-03-24 2004-10-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
US6037340A (en) 1997-05-28 2000-03-14 Cadus Pharmaceutical Corporation Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds
DE19744026A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
WO1999046244A1 (en) 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
NZ521068A (en) * 2000-03-29 2005-04-29 Cyclacel Ltd 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
WO2002030353A2 (en) 2000-10-12 2002-04-18 Smithkline Beecham Corporation NF-λB INHIBITORS

Also Published As

Publication number Publication date
CN1538968A (zh) 2004-10-20
CA2454702A1 (en) 2003-02-06
BR0211472A (pt) 2004-11-09
US20040235821A1 (en) 2004-11-25
EP1421079B1 (en) 2007-02-07
ATE353327T1 (de) 2007-02-15
JP2004536869A (ja) 2004-12-09
NO20040314L (no) 2004-03-25
JP2010111683A (ja) 2010-05-20
DE60218048D1 (de) 2007-03-22
US7098240B2 (en) 2006-08-29
NZ530751A (en) 2005-09-30
MXPA04000755A (es) 2004-04-20
EP1421079A1 (en) 2004-05-26
SE0102617D0 (sv) 2001-07-25
ZA200400494B (en) 2005-04-22
ES2280559T3 (es) 2007-09-16
IL160023A0 (en) 2004-06-20
KR20040018521A (ko) 2004-03-03
WO2003010163A1 (en) 2003-02-06

Similar Documents

Publication Publication Date Title
DE60218048T2 (de) Thiophenverbindungen als arzneimittel
DE60103132T2 (de) Heteroaromatische carboxamid-derivate und ihre verwendung als hemmer des enzyms ikk-2
KR100931172B1 (ko) 신규 화합물
US20090215829A1 (en) Thiophene carboxamides as inhibitors of the enzyme ikk-2
US20040110741A1 (en) Substituted pyrazolyl compounds for the treatment of inflammation
US7572826B2 (en) Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme IKK-2
AU2004203967B2 (en) Thiophene carboxamides as inhibitors of the enzyme IKK-2
AU2002321970A1 (en) Novel compounds
HK1082250B (en) Thiophene carboxamides as inhibitors of the enzyme ikk-2

Legal Events

Date Code Title Description
8364 No opposition during term of opposition