DE60216111D1 - Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz - Google Patents

Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz

Info

Publication number
DE60216111D1
DE60216111D1 DE60216111T DE60216111T DE60216111D1 DE 60216111 D1 DE60216111 D1 DE 60216111D1 DE 60216111 T DE60216111 T DE 60216111T DE 60216111 T DE60216111 T DE 60216111T DE 60216111 D1 DE60216111 D1 DE 60216111D1
Authority
DE
Germany
Prior art keywords
magnetic resonance
derivatives
peptide conjugates
imaging magnetic
metallic complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216111T
Other languages
English (en)
Other versions
DE60216111T2 (de
Inventor
Silvio Aime
Eliana Gianolio
Giancarlo Morelli
Carlo Pedone
Diego Tesauro
Luciano Lattuada
Massimo Visigalli
Lucio Anelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Application granted granted Critical
Publication of DE60216111D1 publication Critical patent/DE60216111D1/de
Publication of DE60216111T2 publication Critical patent/DE60216111T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
DE60216111T 2001-08-03 2002-07-26 Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz Expired - Lifetime DE60216111T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20011708 2001-08-03
IT2001MI001708A ITMI20011708A1 (it) 2001-08-03 2001-08-03 Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
PCT/EP2002/008382 WO2003014157A2 (en) 2001-08-03 2002-07-26 Peptides conjugates, their derivatives with metal complexes and use thereof for magnetic resonance imaging (mri)

Publications (2)

Publication Number Publication Date
DE60216111D1 true DE60216111D1 (de) 2006-12-28
DE60216111T2 DE60216111T2 (de) 2007-04-05

Family

ID=11448231

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216111T Expired - Lifetime DE60216111T2 (de) 2001-08-03 2002-07-26 Peptidkonjugate, deren derivate mit metallischen komplexen und deren verwendung zur bildgebenden magnetischen resonanz

Country Status (8)

Country Link
US (1) US20050008573A1 (de)
EP (1) EP1412383B9 (de)
JP (1) JP4216715B2 (de)
AT (1) ATE345355T1 (de)
AU (1) AU2002328981A1 (de)
DE (1) DE60216111T2 (de)
IT (1) ITMI20011708A1 (de)
WO (1) WO2003014157A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD20030174A1 (it) * 2003-07-31 2003-10-29 Univ Padova Coniugati polimerici per diagnostica e terapia
CN1993357B (zh) 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
WO2006128643A2 (en) * 2005-05-31 2006-12-07 Inbios S.R.L. Supramolecular aggregates containing chelating agents and bioactive peptides as effective and selective delivery tools for drugs and contrast agents in mri or nuclear medicine
EP1928507B1 (de) * 2005-09-09 2015-11-11 Georgia State University Research Foundation, Inc. Gezielte kontrastmittel und verfahren für kontrastmittel-targeting
JP5377965B2 (ja) 2005-09-09 2013-12-25 ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド 標的化された造影剤および造影剤を標的化するための方法
US20090110640A1 (en) * 2006-03-29 2009-04-30 Oskar Axelsson Contrast agents for magnetic resonance imaging and spectroscopy consisting of a cyclic oligoamid core of 3 to 4 identicial monomer units with 3 to 4 paramagnetic chelate side chains
WO2008019123A2 (en) 2006-08-04 2008-02-14 Georgia State University Research Foundation, Inc. Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
US8288530B2 (en) 2006-11-06 2012-10-16 The United States Of America, As Represented By The Department Of Health And Human Services Method of preparing macromolecular contrast agents and uses thereof
CA2671431C (en) 2006-12-14 2019-03-26 Georgia State University Research Foundation, Inc. Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity
US20110097742A1 (en) * 2008-04-02 2011-04-28 Jenny Jie Yang Contrast agents, methods for preparing contrast agents, and methods of imaging
EP2279190A1 (de) * 2008-04-18 2011-02-02 Ge Healthcare As Paramagnetische, um einen zentralen kern angeordnete chelate enthaltende verbindungen und ihre verwendung in der magnetresonanzbilddarstellung und spektroskopie
ES2354320B2 (es) * 2008-06-24 2011-10-11 Universidade De Santiago De Compostela Ciclopéptidos marcados magnéticamente con complejos de lantánidos.
WO2015017815A1 (en) 2013-08-01 2015-02-05 Rochester Institute Of Technology Modular imaging agents containing amino acids and peptides
US10265014B2 (en) * 2013-09-06 2019-04-23 Somnology, Inc. System and method for sleep disorder diagnosis and treatment
US10265013B2 (en) * 2013-09-06 2019-04-23 Somnology, Inc. System and method for sleep disorder diagnosis and treatment
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
WO2017106490A1 (en) 2015-12-15 2017-06-22 Mayo Foundation For Medical Education And Research Systems and methods for linear-time clustering for bounded, repeatable, rare events in physiological signals
EP3544964B1 (de) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft Gadolinium-chelat-verbindung mit hoher relaxivität zur verwendung in der magnetresonanzbildgebung
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
GB9215780D0 (en) * 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
IL108308A0 (en) * 1993-01-12 1994-04-12 Sandoz Ag Polypeptides, their production and pharmaceutical compositions containing them
GB9404208D0 (en) * 1994-03-04 1994-04-20 Nycomed Salutar Inc Chelants
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5762909A (en) * 1995-08-31 1998-06-09 General Electric Company Tumor targeting with polymeric molecules having extended conformation
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
IT1315263B1 (it) * 1999-12-21 2003-02-03 Bracco Spa Composti chelanti,loro chelati con ioni metallici paramagnetici, loropreparazione ed uso

Also Published As

Publication number Publication date
WO2003014157A2 (en) 2003-02-20
ITMI20011708A1 (it) 2003-02-03
ATE345355T1 (de) 2006-12-15
JP4216715B2 (ja) 2009-01-28
DE60216111T2 (de) 2007-04-05
EP1412383B9 (de) 2007-10-03
US20050008573A1 (en) 2005-01-13
EP1412383B1 (de) 2006-11-15
WO2003014157A3 (en) 2003-11-13
ITMI20011708A0 (it) 2001-08-03
AU2002328981A1 (en) 2003-02-24
EP1412383A2 (de) 2004-04-28
JP2005510461A (ja) 2005-04-21

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