DE602008003782D1 - Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür - Google Patents

Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür

Info

Publication number
DE602008003782D1
DE602008003782D1 DE602008003782T DE602008003782T DE602008003782D1 DE 602008003782 D1 DE602008003782 D1 DE 602008003782D1 DE 602008003782 T DE602008003782 T DE 602008003782T DE 602008003782 T DE602008003782 T DE 602008003782T DE 602008003782 D1 DE602008003782 D1 DE 602008003782D1
Authority
DE
Germany
Prior art keywords
receptor
tgf
activation
fluorescence
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008003782T
Other languages
English (en)
Inventor
Christian Dr Boekel
Thomas Dr Weidemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
Original Assignee
Technische Universitaet Dresden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dresden filed Critical Technische Universitaet Dresden
Publication of DE602008003782D1 publication Critical patent/DE602008003782D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE602008003782T 2008-07-04 2008-07-04 Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür Active DE602008003782D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08159781A EP2141179B1 (de) 2008-07-04 2008-07-04 Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür

Publications (1)

Publication Number Publication Date
DE602008003782D1 true DE602008003782D1 (de) 2011-01-13

Family

ID=39661394

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008003782T Active DE602008003782D1 (de) 2008-07-04 2008-07-04 Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür

Country Status (4)

Country Link
US (1) US20100021931A1 (de)
EP (1) EP2141179B1 (de)
AT (1) ATE490272T1 (de)
DE (1) DE602008003782D1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2498996C1 (ru) * 2012-06-27 2013-11-20 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Химерный белок, являющийся флуоресцентным биосенсором для одновременной детекции пероксида водорода и фосфатидилинозитол-3,4,5-трифосфата, нуклеиновая кислота, кодирующая такой белок, кассета экспрессии и эукариотическая клетка-хозяин
US20160047000A1 (en) * 2013-03-21 2016-02-18 General Hospital Corporation Methods and systems for treatment of ovarian cancer
CN104163868B (zh) * 2013-05-17 2016-08-03 上海中医药大学 抗金葡菌药物筛选系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060793B2 (en) 1999-05-21 2006-06-13 The Regents Of The University Of California Circularly permuted fluorescent protein indicators
AU5275100A (en) 1999-05-21 2000-12-12 Regents Of The University Of California, The Fluorescent protein indicators
US6469154B1 (en) 1999-05-21 2002-10-22 The Regents Of The University Of California Fluorescent protein indicators
JP2002253261A (ja) 2001-03-05 2002-09-10 Inst Of Physical & Chemical Res 蛍光タンパク質
WO2005019447A1 (ja) 2003-08-26 2005-03-03 Japan Science And Technology Agency 単色蛍光プローブ

Also Published As

Publication number Publication date
EP2141179B1 (de) 2010-12-01
ATE490272T1 (de) 2010-12-15
EP2141179A1 (de) 2010-01-06
US20100021931A1 (en) 2010-01-28

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