DE602005024805D1 - Adenovirus/alphavirus-hybrid-vektor zur effektiven verabreichung und expression von therapeutischen genen in tumorzellen - Google Patents
Adenovirus/alphavirus-hybrid-vektor zur effektiven verabreichung und expression von therapeutischen genen in tumorzellenInfo
- Publication number
- DE602005024805D1 DE602005024805D1 DE602005024805T DE602005024805T DE602005024805D1 DE 602005024805 D1 DE602005024805 D1 DE 602005024805D1 DE 602005024805 T DE602005024805 T DE 602005024805T DE 602005024805 T DE602005024805 T DE 602005024805T DE 602005024805 D1 DE602005024805 D1 DE 602005024805D1
- Authority
- DE
- Germany
- Prior art keywords
- sequence
- hybrid vector
- adenoviral
- adenovirus
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 241000710929 Alphavirus Species 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 210000004881 tumor cell Anatomy 0.000 title abstract 2
- 241000701161 unidentified adenovirus Species 0.000 title abstract 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 abstract 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 abstract 2
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000008488 polyadenylation Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
- C12N15/8613—Chimaeric vector systems comprising heterologous sequences for production of another viral vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200401219A ES2292271B1 (es) | 2004-05-20 | 2004-05-20 | Un vector hibrido adenovirus-alfavirus para la administracion eficaz y expresion de genes terapeuticos en celulas tumorales. |
| PCT/ES2005/000277 WO2005112541A2 (es) | 2004-05-20 | 2005-05-18 | Un vector híbrido adenovirus-alfavirus para la administración eficaz y expresión de genes terapéuticos en células tumorales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005024805D1 true DE602005024805D1 (de) | 2010-12-30 |
Family
ID=35428710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005024805T Active DE602005024805D1 (de) | 2004-05-20 | 2005-05-18 | Adenovirus/alphavirus-hybrid-vektor zur effektiven verabreichung und expression von therapeutischen genen in tumorzellen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7850957B2 (de) |
| EP (1) | EP1760153B1 (de) |
| JP (1) | JP4767945B2 (de) |
| CN (1) | CN100580085C (de) |
| AT (1) | ATE488596T1 (de) |
| AU (2) | AU2005244625A1 (de) |
| BR (1) | BRPI0510905A (de) |
| CA (1) | CA2567455A1 (de) |
| CY (1) | CY1111496T1 (de) |
| DE (1) | DE602005024805D1 (de) |
| DK (1) | DK1760153T3 (de) |
| ES (2) | ES2292271B1 (de) |
| HR (1) | HRP20110059T1 (de) |
| MX (1) | MXPA06013277A (de) |
| PL (1) | PL1760153T3 (de) |
| PT (1) | PT1760153E (de) |
| RS (1) | RS51559B (de) |
| RU (1) | RU2394104C2 (de) |
| SI (1) | SI1760153T1 (de) |
| WO (1) | WO2005112541A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361710C (zh) * | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
| EP1900749A1 (de) * | 2006-09-12 | 2008-03-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nukleinsäuren zur Expression von Polynukleotiden in Säuger-Krebszellen |
| AU2007327452B2 (en) * | 2006-11-28 | 2012-08-30 | Proyecto De Biomedicina Cima, S.L. | Viral vector and its applications |
| WO2011119773A1 (en) | 2010-03-23 | 2011-09-29 | Roeth Jeremiah F | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
| CN101966341B (zh) * | 2010-09-30 | 2012-06-27 | 中国农业科学院哈尔滨兽医研究所 | 腺病毒/甲病毒复制子嵌合载体猪瘟疫苗及其应用 |
| JP2014504149A (ja) * | 2010-10-28 | 2014-02-20 | ヴァージニア コモンウェルス ユニバーシティ | 治療と併用する癌画像診断：セラノスティックス |
| KR102235603B1 (ko) * | 2013-02-01 | 2021-04-05 | 셀렉시스 에스. 에이. | 향상된 이식유전자 발현 및 가공 |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| EP2878674A1 (de) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stabile Episomen auf Basis von nichtintegrativen lentiviralen Vektoren |
| CN106367401A (zh) * | 2016-08-29 | 2017-02-01 | 黄朝述 | 具有基因协同元件的病毒及其应用 |
| CN118718020A (zh) * | 2016-12-09 | 2024-10-01 | 基因药物株式会社 | 含有表达细胞外基质的降解因子的重组腺病毒的抗癌组合物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9003978D0 (sv) * | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| US5144482A (en) | 1991-05-13 | 1992-09-01 | Gould Dennis R | Three dimensional viewing apparatus including a stack of transparent plates and related method |
| WO1995016772A1 (en) * | 1993-12-14 | 1995-06-22 | Cornell Research Foundation, Inc. | Adenovirus gene expression system |
| SE9401091D0 (sv) * | 1994-03-31 | 1994-03-31 | Bioption Ab | Alphavirus cDNA vectors |
| US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
| US5985846A (en) | 1995-06-07 | 1999-11-16 | Baylor College Of Medicine | Gene therapy for muscular dystrophy |
| US6254862B1 (en) * | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| DE19543553B4 (de) * | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
| EP0954579A1 (de) * | 1996-06-20 | 1999-11-10 | Merck & Co., Inc. | Gentherapie gegen Fettleibigkeit |
| AU729690B2 (en) * | 1996-10-10 | 2001-02-08 | Henrik Garoff | Alphavirus-retrovirus vectors |
| CA2272121A1 (en) * | 1996-11-19 | 1998-05-28 | Uab Research Foundation | Chimeric retrovirus/adenovirus system |
| WO1998046778A1 (en) * | 1997-04-11 | 1998-10-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Transgenomic viruses and the use thereof |
| CA2309826A1 (en) * | 1997-11-14 | 1999-05-27 | Connaught Laboratories Limited | Alphavirus vectors for paramyxovirus vaccines |
| DK1029069T3 (da) * | 1997-11-14 | 2006-12-18 | Sanofi Pasteur Ltd | Alphavirus-vektor |
| NZ505325A (en) * | 1997-12-23 | 2003-07-25 | Crucell Holland B | Adeno-associated virus and adenovirus chimeric recombinant viruses useful for the integration of foreign genetic information into the chromosomal dna of target cells |
| US5981225A (en) * | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| JP2002517234A (ja) * | 1998-06-09 | 2002-06-18 | メルク・アンド・カンパニー・インコーポレーテッド | 遺伝子治療用の新規アデノウイルスベクター |
| GB9817660D0 (en) * | 1998-08-13 | 1998-10-07 | Angeletti P Ist Richerche Bio | Adenoviral vectors encoding erythropoietin and their use in gene therapy |
| US6375944B1 (en) * | 1998-09-25 | 2002-04-23 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for enhancing the immunostimulatory effect of interleukin-12 |
| EP1151091A4 (de) * | 1999-02-04 | 2002-09-04 | Merck & Co Inc | VERBESSERTES HELFERABHäNGIGES VEKTORSYSTEM FüR DIE GENTHERAPHIE |
| AU5448400A (en) * | 1999-05-28 | 2000-12-18 | Mount Sinai School Of Medicine, The | A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors |
| EP1318839A2 (de) * | 2000-03-24 | 2003-06-18 | Cell Genesys, Inc. | Verfahren zur behandlung von neoplasien durch anwendung einer kombination aus zielzellspezifische adenovirale vektoren , chemo- und strahlentherapie |
| DE10056210A1 (de) * | 2000-11-13 | 2002-05-29 | Arimedes Biotechnology Gmbh | Virales Expressionssystem |
| AU2002244055A1 (en) * | 2001-02-12 | 2002-08-28 | The Penn State Research Foundation | Fra-1 expression in brain cancer |
| WO2002079447A2 (en) * | 2001-03-30 | 2002-10-10 | Avigenics, Inc. | Avian lysozyme promoter |
| US7238346B2 (en) * | 2002-07-08 | 2007-07-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | High capacity recombinant adenoviral vector for treatment of hemophilia A |
-
2004
- 2004-05-20 ES ES200401219A patent/ES2292271B1/es not_active Expired - Fee Related
-
2005
- 2005-05-18 BR BRPI0510905-1A patent/BRPI0510905A/pt not_active IP Right Cessation
- 2005-05-18 ES ES05750184T patent/ES2356322T3/es active Active
- 2005-05-18 RU RU2006145306/13A patent/RU2394104C2/ru not_active IP Right Cessation
- 2005-05-18 PT PT05750184T patent/PT1760153E/pt unknown
- 2005-05-18 EP EP05750184A patent/EP1760153B1/de active Active
- 2005-05-18 PL PL05750184T patent/PL1760153T3/pl unknown
- 2005-05-18 JP JP2007517308A patent/JP4767945B2/ja not_active Expired - Fee Related
- 2005-05-18 US US11/569,303 patent/US7850957B2/en not_active Expired - Fee Related
- 2005-05-18 CA CA002567455A patent/CA2567455A1/en not_active Abandoned
- 2005-05-18 AU AU2005244625A patent/AU2005244625A1/en not_active Abandoned
- 2005-05-18 DE DE602005024805T patent/DE602005024805D1/de active Active
- 2005-05-18 AT AT05750184T patent/ATE488596T1/de active
- 2005-05-18 RS RSP-2011/0023A patent/RS51559B/en unknown
- 2005-05-18 CN CN200580016133A patent/CN100580085C/zh not_active Expired - Fee Related
- 2005-05-18 WO PCT/ES2005/000277 patent/WO2005112541A2/es active Application Filing
- 2005-05-18 MX MXPA06013277A patent/MXPA06013277A/es active IP Right Grant
- 2005-05-18 DK DK05750184.3T patent/DK1760153T3/da active
- 2005-05-18 SI SI200531199T patent/SI1760153T1/sl unknown
-
2010
- 2010-08-20 AU AU2010214637A patent/AU2010214637B2/en not_active Ceased
-
2011
- 2011-01-24 HR HR20110059T patent/HRP20110059T1/hr unknown
- 2011-01-31 CY CY20111100097T patent/CY1111496T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1111496T1 (el) | 2015-08-05 |
| US20070224170A1 (en) | 2007-09-27 |
| AU2010214637B2 (en) | 2012-04-26 |
| WO2005112541A2 (es) | 2005-12-01 |
| CN1957086A (zh) | 2007-05-02 |
| BRPI0510905A (pt) | 2007-11-06 |
| DK1760153T3 (da) | 2011-02-21 |
| ATE488596T1 (de) | 2010-12-15 |
| CA2567455A1 (en) | 2005-12-01 |
| MXPA06013277A (es) | 2007-02-28 |
| US7850957B2 (en) | 2010-12-14 |
| HRP20110059T1 (hr) | 2011-03-31 |
| RU2006145306A (ru) | 2008-06-27 |
| EP1760153A2 (de) | 2007-03-07 |
| JP2007537742A (ja) | 2007-12-27 |
| ES2356322T3 (es) | 2011-04-06 |
| RS51559B (en) | 2011-06-30 |
| PL1760153T3 (pl) | 2011-04-29 |
| JP4767945B2 (ja) | 2011-09-07 |
| ES2292271B1 (es) | 2009-02-16 |
| ES2292271A1 (es) | 2008-03-01 |
| WO2005112541A3 (es) | 2006-03-23 |
| CN100580085C (zh) | 2010-01-13 |
| PT1760153E (pt) | 2010-12-23 |
| RU2394104C2 (ru) | 2010-07-10 |
| SI1760153T1 (sl) | 2011-02-28 |
| AU2010214637A1 (en) | 2010-09-16 |
| AU2005244625A1 (en) | 2005-12-01 |
| EP1760153B1 (de) | 2010-11-17 |
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