DE602005018613D1 - Chemisch stabile zusammensetzungen von 4-hydroxy-tamoxifen - Google Patents

Chemisch stabile zusammensetzungen von 4-hydroxy-tamoxifen

Info

Publication number
DE602005018613D1
DE602005018613D1 DE602005018613T DE602005018613T DE602005018613D1 DE 602005018613 D1 DE602005018613 D1 DE 602005018613D1 DE 602005018613 T DE602005018613 T DE 602005018613T DE 602005018613 T DE602005018613 T DE 602005018613T DE 602005018613 D1 DE602005018613 D1 DE 602005018613D1
Authority
DE
Germany
Prior art keywords
tamoxifes
hydroxy
chemically stable
stable compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005018613T
Other languages
German (de)
English (en)
Inventor
Dana C Hilt
Valerie Masini-Eteve
Richard Fedynec
Brigitte Taravella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Besins International SAS
Original Assignee
Laboratoires Besins International SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Besins International SAS filed Critical Laboratoires Besins International SAS
Publication of DE602005018613D1 publication Critical patent/DE602005018613D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602005018613T 2004-03-22 2005-03-18 Chemisch stabile zusammensetzungen von 4-hydroxy-tamoxifen Expired - Lifetime DE602005018613D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/805,530 US20050208139A1 (en) 2004-03-22 2004-03-22 Chemically stable compositions of 4-hydroxy tamoxifen
EP04290762A EP1579857A1 (en) 2004-03-22 2004-03-22 Chemically stable compositions of 4-hydroxy tamoxifen
PCT/EP2005/003455 WO2005092310A2 (en) 2004-03-22 2005-03-18 Chemically stable compositions of 4-hydroxy tamoxifen

Publications (1)

Publication Number Publication Date
DE602005018613D1 true DE602005018613D1 (de) 2010-02-11

Family

ID=34854723

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005018613T Expired - Lifetime DE602005018613D1 (de) 2004-03-22 2005-03-18 Chemisch stabile zusammensetzungen von 4-hydroxy-tamoxifen

Country Status (21)

Country Link
US (1) US20050208139A1 (enExample)
EP (4) EP1579857A1 (enExample)
JP (1) JP5489407B2 (enExample)
CN (1) CN101080222B (enExample)
AR (1) AR048587A1 (enExample)
AT (1) ATE453387T1 (enExample)
AU (1) AU2005227073B2 (enExample)
CA (1) CA2557806C (enExample)
DE (1) DE602005018613D1 (enExample)
DK (1) DK1727532T3 (enExample)
ES (3) ES2337069T3 (enExample)
IL (2) IL177778A (enExample)
MX (1) MXPA06010928A (enExample)
NO (1) NO337298B1 (enExample)
NZ (1) NZ549664A (enExample)
PL (1) PL1727532T3 (enExample)
PT (1) PT1727532E (enExample)
RU (1) RU2389483C2 (enExample)
TW (1) TWI401078B (enExample)
WO (1) WO2005092310A2 (enExample)
ZA (1) ZA200607291B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054557A2 (en) * 2002-12-18 2004-07-01 Laboratoires Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
JP4684655B2 (ja) * 2002-12-18 2011-05-18 ラボラトワール ブザン アンテルナスィヨナル ４−ヒドロキシタモキシフェンによる乳房密度低下
CA2519980C (en) * 2003-04-01 2012-04-10 Laboratoires Besins International Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
US7767717B2 (en) 2003-06-09 2010-08-03 Ascend Therapeutics, Inc. Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1799201B1 (en) * 2004-10-14 2008-11-26 Laboratoires Besins International 4-hydroxy tamoxifen gel formulations
EP1647271A1 (en) * 2004-10-14 2006-04-19 Laboratoires Besins International 4-Hydroxy tamoxifen gel formulations
WO2011046596A2 (en) * 2009-10-13 2011-04-21 Duquesne University Of The Holy Spirit, A Nonprofit Corporation Organized Under The Laws Of The Commonwealth Of Pennsylvania Anti-cancer tamoxifen-melatonin hybrid ligand
CA2878866C (en) * 2011-07-14 2021-02-23 Able Cerebral, Llc A composition, device and method for delayed and sustained release of brain energy molecules
US20230026978A1 (en) * 2021-07-07 2023-01-26 Ohio State Innovation Foundation Photoisomerized compositions of anthocyanins and methods of making and use thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
US5475851A (en) * 1986-04-14 1995-12-12 National Instruments Corporation Method and apparatus for improved local and global variable capabilities in a graphical data flow program
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
CA2032695A1 (en) 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US6160549A (en) * 1994-07-29 2000-12-12 Oracle Corporation Method and apparatus for generating reports using declarative tools
DE4435784C2 (de) * 1994-10-06 1998-10-29 Heraeus Electro Nite Int Elektrisch beheizbarer Starterkat
US5777621A (en) * 1994-12-22 1998-07-07 Apple Computer, Inc. Quality control mechanism for three-dimensional graphics rendering
AU725286B2 (en) * 1996-01-20 2000-10-12 Bradford University Tamoxifen and analogues thereof
ES2156361T5 (es) * 1996-03-29 2012-12-26 Keyvest Gmbh Cosmético o bien composición cosmética para el alisado y la tersura de la piel en el caso de tejido adiposo afectado, en especial en el caso de la "celulitis"
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
EP1043986B1 (en) * 1997-12-23 2003-04-16 Hexal Ag Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin
JP2000038335A (ja) * 1998-07-22 2000-02-08 Kanebo Ltd 皮膚化粧料
AU6890800A (en) 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20030175329A1 (en) * 2001-10-04 2003-09-18 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
PT1317921E (pt) * 2001-12-07 2009-11-06 Besins Mfg Belgium Composição farmacêutica sob a forma de gel ou de solução à base de di-hidrotestosterona, seu processo de preparação e suas utilizações
US6695171B2 (en) * 2002-02-12 2004-02-24 Seaquistperfect Dispensing Foreign, Inc. Pump dispenser
JP4684655B2 (ja) * 2002-12-18 2011-05-18 ラボラトワール ブザン アンテルナスィヨナル ４−ヒドロキシタモキシフェンによる乳房密度低下
WO2004054557A2 (en) * 2002-12-18 2004-07-01 Laboratoires Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
CA2519980C (en) * 2003-04-01 2012-04-10 Laboratoires Besins International Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
US7767717B2 (en) * 2003-06-09 2010-08-03 Ascend Therapeutics, Inc. Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
PL1694319T3 (pl) * 2003-12-15 2009-01-30 Besins Healthcare Lu Sarl Zastosowanie 4-hydroksytamoksyfenu do wytwarzania leku do leczenia ginekomastii
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1647271A1 (en) * 2004-10-14 2006-04-19 Laboratoires Besins International 4-Hydroxy tamoxifen gel formulations

Also Published As

Publication number Publication date
NO20064765L (no) 2006-10-20
CA2557806C (en) 2011-08-30
TWI401078B (zh) 2013-07-11
IL177778A0 (en) 2006-12-31
JP5489407B2 (ja) 2014-05-14
AU2005227073B2 (en) 2011-06-23
TW200533334A (en) 2005-10-16
IL215897A0 (en) 2011-12-29
AU2005227073A1 (en) 2005-10-06
NZ549664A (en) 2011-01-28
AR048587A1 (es) 2006-05-10
ZA200607291B (en) 2008-04-30
RU2006137282A (ru) 2008-04-27
IL177778A (en) 2011-12-29
EP1579857A1 (en) 2005-09-28
DK1727532T3 (da) 2010-05-03
MXPA06010928A (es) 2006-12-15
NO337298B1 (no) 2016-03-07
EP2269599B1 (en) 2013-02-20
ES2337069T3 (es) 2010-04-20
PT1727532E (pt) 2010-03-30
HK1139332A1 (en) 2010-09-17
ES2402921T3 (es) 2013-05-10
EP1727532A2 (en) 2006-12-06
WO2005092310A3 (en) 2005-12-01
ATE453387T1 (de) 2010-01-15
US20050208139A1 (en) 2005-09-22
EP2147670A1 (en) 2010-01-27
EP2147670B1 (en) 2014-10-01
HK1098674A1 (en) 2007-07-27
CN101080222B (zh) 2013-08-07
ES2517894T3 (es) 2014-11-04
CN101080222A (zh) 2007-11-28
RU2389483C2 (ru) 2010-05-20
WO2005092310A2 (en) 2005-10-06
IL215897A (en) 2014-09-30
EP1727532B1 (en) 2009-12-30
PL1727532T3 (pl) 2010-06-30
JP2007530498A (ja) 2007-11-01
EP2269599A1 (en) 2011-01-05
CA2557806A1 (en) 2005-10-06

Similar Documents

Publication Publication Date Title
CY2024008I2 (el) Συνδυασμος ο οποιος περιλαμβανει εναν ευσταθη κρυσταλλο μιας ενωσης 4-οξοκινολινης
DE602005027308D1 (de) Stabile salze von olanzapin
DE602005012267D1 (de) N von geräten
DK3395339T3 (da) Hurtigt opløsende formulering af cinacalcet-hcl
EP1420783A4 (en) STABLE EMULSION COMPOSITION
PL2277977T3 (pl) Kompozycje zawierające olefiny podstawione fluorem
EP1746135A4 (en) HARDENING COMPOSITION
DK1720866T3 (da) Fremgangsmåde
DK1763673T3 (da) Anvendelser af gelformuleringer
EP1818368A4 (en) HARDENING COMPOSITION
EP1788047A4 (en) WATER REPELLENT / OIL-REPELLING COMPOSITION
DK1846566T3 (da) Stabile nåleformede krystaller af natamycin
DK1931315T3 (da) Depotformuleringer af nalbufin
EP1832626A4 (en) HARDENING COMPOSITION
DK1776090T3 (da) Stabiliseret prostaglandinsammensætning
ES2845143T8 (es) Composición de trombina estable
ATE453387T1 (de) Chemisch stabile zusammensetzungen von 4-hydroxy- tamoxifen
EP1875926A4 (en) Stable emulsion composition
DE602006004426D1 (de) Stabile wässrige Esterquat-Zusammensetztungen
PT1763520E (pt) Utilização de benzopiranonas trissubstituídas
FI20041057L (fi) Pelkistysainekoostumus
FR2871686B1 (fr) Composition anti-decoloration
ATE517662T1 (de) Stiftzusammensetzungen
ATE499348T1 (de) Stabiler polymorph von bifeprunoxmesilat
DE112004001180D2 (de) Klebstoffzusammensetzung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition