DE602004010785D1 - 2-cyanopyrrolopyrimidine und deren pharmazeutische verwendung - Google Patents

2-cyanopyrrolopyrimidine und deren pharmazeutische verwendung

Info

Publication number
DE602004010785D1
DE602004010785D1 DE602004010785T DE602004010785T DE602004010785D1 DE 602004010785 D1 DE602004010785 D1 DE 602004010785D1 DE 602004010785 T DE602004010785 T DE 602004010785T DE 602004010785 T DE602004010785 T DE 602004010785T DE 602004010785 D1 DE602004010785 D1 DE 602004010785D1
Authority
DE
Germany
Prior art keywords
cyanopyrrolopyrimidine
pharmaceutical use
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004010785T
Other languages
English (en)
Other versions
DE602004010785T2 (de
Inventor
Francis Paul Buxton
Takeru Ehara
Pamposh Ganju
Allan Hallett
Ozamu Irie
Atsuko Iwasaki
Takanori Kanazawa
Keiichi Masuya
Kazuhiko Nonomura
Junichi Sakaki
Christopher Robert Snell
Chuanheng Song
Keiko Tanabe
Naoki Teno
Ichiro Umemura
Fumiaki Yokokawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0302748A external-priority patent/GB0302748D0/en
Priority claimed from GB0304641A external-priority patent/GB0304641D0/en
Priority claimed from GB0304642A external-priority patent/GB0304642D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE602004010785D1 publication Critical patent/DE602004010785D1/de
Application granted granted Critical
Publication of DE602004010785T2 publication Critical patent/DE602004010785T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004010785T 2003-02-06 2004-02-05 2-cyanopyrrolopyrimidine und deren pharmazeutische verwendung Expired - Fee Related DE602004010785T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0302748A GB0302748D0 (en) 2003-02-06 2003-02-06 Organic compounds
GB0302748 2003-02-06
GB0304642 2003-02-28
GB0304641 2003-02-28
GB0304641A GB0304641D0 (en) 2003-02-28 2003-02-28 Organic compounds
GB0304642A GB0304642D0 (en) 2003-02-28 2003-02-28 Organic compounds
PCT/EP2004/001081 WO2004069256A1 (en) 2003-02-06 2004-02-05 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof

Publications (2)

Publication Number Publication Date
DE602004010785D1 true DE602004010785D1 (de) 2008-01-31
DE602004010785T2 DE602004010785T2 (de) 2008-12-04

Family

ID=32854008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004010785T Expired - Fee Related DE602004010785T2 (de) 2003-02-06 2004-02-05 2-cyanopyrrolopyrimidine und deren pharmazeutische verwendung

Country Status (17)

Country Link
US (1) US20060247251A1 (de)
EP (1) EP1592426B1 (de)
JP (1) JP4499667B2 (de)
AR (1) AR043692A1 (de)
AT (1) ATE381335T1 (de)
AU (1) AU2004210422B2 (de)
BR (1) BRPI0407327A (de)
CA (1) CA2514287A1 (de)
DE (1) DE602004010785T2 (de)
ES (1) ES2297378T3 (de)
HK (1) HK1084883A1 (de)
MX (1) MXPA05008348A (de)
PE (1) PE20050068A1 (de)
PL (1) PL378135A1 (de)
PT (1) PT1592426E (de)
TW (1) TW200420566A (de)
WO (1) WO2004069256A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0201980D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
GB0304640D0 (en) * 2003-02-28 2003-04-02 Novartis Ag Organic compounds
EP1797883A3 (de) * 2003-04-28 2007-08-01 Novartis AG Pharmezeutische Zusammensetzung einen Cathepsin S Inhibitor und ein Opioid enthaltend
AU2005243238B2 (en) * 2004-05-03 2011-11-10 Janssen Pharmaceutica N.V. Novel indole derivatives as selective androgen receptor modulators (SARMS)
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
US9107864B2 (en) 2004-06-07 2015-08-18 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
PE20120493A1 (es) 2009-06-29 2012-05-20 Incyte Corp Pirimidinonas como inhibidores de pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
UY33304A (es) * 2010-04-02 2011-10-31 Amgen Inc Compuestos heterocíclicos y sus usos
CA2796311A1 (en) 2010-04-14 2011-10-20 Incyte Corporation Fused derivatives as pi3k.delta. inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012012874A1 (en) 2010-07-26 2012-02-02 Qu Biologics Inc. Immunogenic anti-inflammatory compositions
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
KR101982475B1 (ko) 2011-09-02 2019-05-27 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
CN103304525B (zh) * 2012-03-08 2015-08-05 深圳海王药业有限公司 一种制备达非那新中间体5-(卤代乙基)-2,3-二氢苯并呋喃的方法
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CA2870527A1 (en) * 2012-04-17 2013-10-24 Astellas Pharma Inc. Nitrogenated bicyclic aromatic heterocyclic compound
AU2013276519B2 (en) 2012-06-15 2017-05-25 Janssen Sciences Ireland Uc 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
US9617289B2 (en) 2012-10-16 2017-04-11 Janssen Sciences Ireland Uc RSV antiviral compounds
WO2014143638A1 (en) * 2013-03-14 2014-09-18 Novartis Ag 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases
CN105849090A (zh) 2013-10-30 2016-08-10 诺华股份有限公司 2-苄基-苯并咪唑补体因子b抑制剂及其用途
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為ｒｓｖ抗病毒化合物之螺脲化合物
CN106456740B (zh) 2014-05-02 2021-06-08 Qu生物制药公司 抗微生物免疫调节
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
MY187502A (en) 2015-02-27 2021-09-24 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
US10537552B2 (en) 2015-05-05 2020-01-21 Carafe Drug Innovation, Llc Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
MX2020003575A (es) * 2017-10-27 2020-07-22 Esteve Pharmaceuticals Sa Nuevos derivados de alcoxiamino para tratar dolor y estados relacionados con dolor.
TW202024083A (zh) 2018-09-03 2020-07-01 德商拜耳廠股份有限公司 3,9-二氮雜螺[5.5]十一烷化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051577A (en) * 1996-03-15 2000-04-18 Novartis Ag N-7-heterocyclyl pyrrolo[2,3-D]pyrimidines and the use thereof
EP1091738B1 (de) * 1998-06-30 2006-12-06 Eli Lilly And Company BICYCLISCHE sPLA 2-INHIBITOREN
GB0100622D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
US20030144234A1 (en) * 2001-08-30 2003-07-31 Buxton Francis Paul Methods for the treatment of chronic pain and compositions therefor
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
JP4499667B2 (ja) 2010-07-07
EP1592426B1 (de) 2007-12-19
ES2297378T3 (es) 2008-05-01
HK1084883A1 (en) 2006-08-11
DE602004010785T2 (de) 2008-12-04
EP1592426A1 (de) 2005-11-09
BRPI0407327A (pt) 2006-01-10
PE20050068A1 (es) 2005-03-11
MXPA05008348A (es) 2005-11-04
ATE381335T1 (de) 2008-01-15
PL378135A1 (pl) 2006-03-06
WO2004069256A1 (en) 2004-08-19
TW200420566A (en) 2004-10-16
AU2004210422A1 (en) 2004-08-19
AR043692A1 (es) 2005-08-10
JP2006516554A (ja) 2006-07-06
WO2004069256A8 (en) 2004-10-14
US20060247251A1 (en) 2006-11-02
AU2004210422B2 (en) 2008-01-17
CA2514287A1 (en) 2004-08-19
PT1592426E (pt) 2008-03-13

Similar Documents

Publication Publication Date Title
ATE381335T1 (de) 2-cyanopyrrolopyrimidine und deren pharmazeutische verwendung
ATE370958T1 (de) Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung
DE602004021904D1 (de) Gyraseinhibitoren und deren verwendungen
DE60226704D1 (de) Acylierte 6,7,8,9-tetrahydro-5h-benzocycloheptenyl-amine und deren pharmazeutische verwendung
ATE517081T1 (de) Hydroxamsäureester und deren pharmazeutische verwendung
DE60138768D1 (de) Glucopyranosylpyrazolderivate und deren verwendung in arzneimitteln
ATA13842001A (de) Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung
ATE459647T1 (de) Humane il-18 substitutionsmutanten und deren konjugate
DE60208351D1 (de) Glukopyranosyloxybenzylbenzolderivate und deren medizinische verwendung
DE60237580D1 (de) Glykopyranosyloxypyrazolderivate und deren medizinische verwendung
ATE524178T1 (de) Acylierte, heteroaryl-kondensierte cycloalkenylamine und deren verwendung als arzneimittel
ATE529420T1 (de) 3-ä(2-ää4-hexyloxycarbonylamino-imino-methyl)- phenylaminoü-methylü-1-methyl-1h-benzimidazol-5 carbonyl)-pyridin-2-yl-aminoü-propionsäure- ethylester-methansulfonat-hemihydrat und dessen verwendung als arzneimittel
DE60318188D1 (de) Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
DE60105859D1 (de) Urazil Verbindungen und deren Verwendung
DE602004027354D1 (de) SUBSTITUIERTE 8y-PYRIDINYLDIHYDROSPIROiCYCLOALKYL PYRIMIDOi1,2-A PYRIMIDIN-6-ON- UND 8y-PYRIMIDINYLDIHYDROSPIROiCYCLOALKYL PYRIMIDOi1,2-A PYRIMIDIN-6-ONDERIVATE UND DEREN VERWENDUNG BEI NEURODEGENERATIVEN KRANKHEITEN
DE502004000891D1 (de) Organosilylfunktionalisierte partikel und deren herstellung
ATE555097T1 (de) 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente
DE60224194D1 (de) Arzneizusammensetzungen enthaltend terbinafin und deren verwendung
DE602005012287D1 (de) Biotinylierte hexadecasaccharide, pharmazeutische zusammensetzungen daraus und deren verwendung
ATE517104T1 (de) Beta-carbolinderivate und deren pharmazeutische verwendung gegen depression und angst
ATE371653T1 (de) Benzoxazinderivate und deren verwendungen
DE602004022169D1 (de) Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
DE602004030564D1 (de) 2-substituierte phenyl-5,7-dialkyl-3,7-dihydropyrrolä2,3-dü pyrimidin-4-onderivate, deren herstellung und pharmazeutische verwendung
DE60336999D1 (de) Melatonin enthaltende pharmazeutische formulierung
DE60310526D1 (de) Ivabradin enthaltende pharmazeutische zusammensetzung mit oraler dispersion

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Ref document number: 1592426

Country of ref document: EP

Effective date: 20110901

R082 Change of representative

Ref document number: 1592426

Country of ref document: EP

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE