DE602004009905D1 - 6-substituierte nikotinamidderivate als opioidrezeptorantagonisten - Google Patents
6-substituierte nikotinamidderivate als opioidrezeptorantagonistenInfo
- Publication number
- DE602004009905D1 DE602004009905D1 DE602004009905T DE602004009905T DE602004009905D1 DE 602004009905 D1 DE602004009905 D1 DE 602004009905D1 DE 602004009905 T DE602004009905 T DE 602004009905T DE 602004009905 T DE602004009905 T DE 602004009905T DE 602004009905 D1 DE602004009905 D1 DE 602004009905D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor antagonists
- opioid receptor
- nicotinamide derivatives
- substituted nicotinamide
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940123257 Opioid receptor antagonist Drugs 0.000 title abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical class NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addiction (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45341403P | 2003-03-07 | 2003-03-07 | |
| US453414P | 2003-03-07 | ||
| PCT/US2004/003360 WO2004080968A1 (en) | 2003-03-07 | 2004-02-25 | 6-substituted nicotinamide derivatives as opioid receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004009905D1 true DE602004009905D1 (de) | 2007-12-20 |
| DE602004009905T2 DE602004009905T2 (de) | 2008-08-28 |
Family
ID=32990768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004009905T Expired - Lifetime DE602004009905T2 (de) | 2003-03-07 | 2004-02-25 | 6-substituierte nikotinamidderivate als opioidrezeptorantagonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7399774B2 (de) |
| EP (1) | EP1613597B1 (de) |
| CN (1) | CN1756746A (de) |
| AT (1) | ATE377589T1 (de) |
| AU (1) | AU2004220112A1 (de) |
| BR (1) | BRPI0407616A (de) |
| CA (1) | CA2518194A1 (de) |
| DE (1) | DE602004009905T2 (de) |
| ES (1) | ES2294475T3 (de) |
| MX (1) | MXPA05009508A (de) |
| WO (1) | WO2004080968A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2305491T3 (es) * | 2002-09-19 | 2008-11-01 | Eli Lilly And Company | Eteres de diarilo como antagonistas de receptores de opioides. |
| MXPA05009508A (es) * | 2003-03-07 | 2005-12-14 | Lilly Co Eli | Derivados de nicotinamida 6-substituida como antagonistas de receptor opioide. |
| US7094572B2 (en) | 2003-03-14 | 2006-08-22 | Bristol-Myers Squibb | Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74 |
| ES2456705T3 (es) | 2003-12-12 | 2014-04-23 | Eli Lilly & Company | Antagonistas de receptores opioides |
| WO2005066164A1 (en) * | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Opioid receptor antagonists |
| ATE399164T1 (de) | 2004-03-12 | 2008-07-15 | Lilly Co Eli | Antagonisten des opioidrezeptors |
| CA2557794A1 (en) | 2004-03-15 | 2005-10-06 | Eli Lilly And Company | Opioid receptor antagonists |
| ATE420858T1 (de) | 2004-03-15 | 2009-01-15 | Lilly Co Eli | 4-(5-(aminomethyl)-indol-1- ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit |
| US20090306052A1 (en) * | 2004-12-07 | 2009-12-10 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| MY146506A (en) * | 2006-05-30 | 2012-08-15 | Janssen Pharmaceutica Nv | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
| EP2054383A2 (de) * | 2006-08-09 | 2009-05-06 | SmithKline Beecham Corporation | Neue verbindungen als antagonisten oder inverse agonisten an opioidrezeptoren |
| JP2010502688A (ja) | 2006-09-08 | 2010-01-28 | ファイザー・プロダクツ・インク | ジアリールエーテル誘導体およびその使用 |
| US20080200458A1 (en) * | 2007-01-18 | 2008-08-21 | Joseph Barbosa | Methods and compositions for the treatment of body composition disorders |
| US20080194557A1 (en) * | 2007-01-18 | 2008-08-14 | Joseph Barbosa | Methods and compositions for the treatment of pain, inflammation and cancer |
| US8278442B2 (en) * | 2007-05-22 | 2012-10-02 | Prosidion Limited | Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| JP2010538055A (ja) | 2007-09-07 | 2010-12-09 | プロシディオン・リミテッド | 二環式アリールおよびヘテロアリール受容体モジュレーター |
| MY163014A (en) * | 2008-01-22 | 2017-07-31 | Lilly Co Eli | Kappa selective opioid receptor antogonist |
| TW200936130A (en) * | 2008-02-26 | 2009-09-01 | Lundbeck & Co As H | Uses of indane compounds |
| US8653100B2 (en) | 2008-04-01 | 2014-02-18 | Abbvie Inc. | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| EP3970723A1 (de) | 2011-02-18 | 2022-03-23 | Asana BioSciences, LLC | Aminoindan-verbindungen zur verwendung in der behandlung von urologischen schmerzen |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2014521682A (ja) | 2011-08-05 | 2014-08-28 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用 |
| CN104011028A (zh) | 2011-11-18 | 2014-08-27 | 艾伯维德国有限责任两合公司 | N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途 |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2014028675A1 (en) | 2012-08-15 | 2014-02-20 | Endo Pharmaceuticals Inc. | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| EP3057958B1 (de) | 2013-10-17 | 2019-05-01 | AbbVie Deutschland GmbH & Co. KG | Aminotetralin- und aminoindanderivate, pharmazeutische zusammensetzungen damit und deren verwendung in der therapie |
| AU2014336153A1 (en) | 2013-10-17 | 2016-04-28 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2022169230A1 (ko) * | 2021-02-03 | 2022-08-11 | 단국대학교 천안캠퍼스 산학협력단 | 6-메톡시니코틴아미드를 유효성분으로 포함하는 근감소증의 예방 또는 치료용 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL114046A0 (en) * | 1994-06-20 | 1995-10-31 | Astra Ab | New opioid peptide antagonists |
| IT1275433B (it) * | 1995-05-19 | 1997-08-07 | Smithkline Beecham Farma | Derivati di diarildiammine |
| DE69711519T2 (de) | 1996-09-05 | 2002-10-31 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische Agonisten |
| EP1049676B1 (de) * | 1997-12-24 | 2005-10-12 | Ortho-Mcneil Pharmaceutical, Inc. | (4)-[aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| US6284769B1 (en) * | 1999-12-03 | 2001-09-04 | The Board Of Trustees Of The University Of Illinois | Nonpeptide kappa opioid receptor antagonists |
| NZ527815A (en) | 2001-03-29 | 2005-05-27 | Lilly Co Eli | N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor |
| ES2305491T3 (es) | 2002-09-19 | 2008-11-01 | Eli Lilly And Company | Eteres de diarilo como antagonistas de receptores de opioides. |
| MXPA05009508A (es) * | 2003-03-07 | 2005-12-14 | Lilly Co Eli | Derivados de nicotinamida 6-substituida como antagonistas de receptor opioide. |
-
2004
- 2004-02-25 MX MXPA05009508A patent/MXPA05009508A/es unknown
- 2004-02-25 AU AU2004220112A patent/AU2004220112A1/en not_active Abandoned
- 2004-02-25 EP EP04714542A patent/EP1613597B1/de not_active Expired - Lifetime
- 2004-02-25 ES ES04714542T patent/ES2294475T3/es not_active Expired - Lifetime
- 2004-02-25 CA CA002518194A patent/CA2518194A1/en not_active Abandoned
- 2004-02-25 BR BRPI0407616-8A patent/BRPI0407616A/pt not_active Application Discontinuation
- 2004-02-25 AT AT04714542T patent/ATE377589T1/de not_active IP Right Cessation
- 2004-02-25 US US10/546,521 patent/US7399774B2/en not_active Expired - Fee Related
- 2004-02-25 DE DE602004009905T patent/DE602004009905T2/de not_active Expired - Lifetime
- 2004-02-25 CN CNA2004800056675A patent/CN1756746A/zh active Pending
- 2004-02-25 WO PCT/US2004/003360 patent/WO2004080968A1/en active IP Right Grant
-
2008
- 2008-07-08 US US12/169,057 patent/US8101638B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1613597A1 (de) | 2006-01-11 |
| BRPI0407616A (pt) | 2006-02-14 |
| WO2004080968A1 (en) | 2004-09-23 |
| ES2294475T3 (es) | 2008-04-01 |
| US8101638B2 (en) | 2012-01-24 |
| US20090023785A1 (en) | 2009-01-22 |
| DE602004009905T2 (de) | 2008-08-28 |
| MXPA05009508A (es) | 2005-12-14 |
| CA2518194A1 (en) | 2004-09-23 |
| CN1756746A (zh) | 2006-04-05 |
| EP1613597B1 (de) | 2007-11-07 |
| ATE377589T1 (de) | 2007-11-15 |
| US20060205715A1 (en) | 2006-09-14 |
| AU2004220112A1 (en) | 2004-09-23 |
| US7399774B2 (en) | 2008-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: PEDREGAL-TERCERO, CONCEPCION, ALCOBENDAS, ES Inventor name: TAKEUCHI, KUMIKO, INDIANAPOLIS, IND., US Inventor name: SIEGEL, MILES GOODMAN, INDIANAPOLIS, IND., US Inventor name: STUCKY, RUSSELL DEAN, INDIANAPOLIS, IND., US |
|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |