DE602004001864D1 - Verbindungen und methoden zur behandlung von proliferativen krankheiten, retinopathie und arthritis - Google Patents
Verbindungen und methoden zur behandlung von proliferativen krankheiten, retinopathie und arthritisInfo
- Publication number
- DE602004001864D1 DE602004001864D1 DE602004001864T DE602004001864T DE602004001864D1 DE 602004001864 D1 DE602004001864 D1 DE 602004001864D1 DE 602004001864 T DE602004001864 T DE 602004001864T DE 602004001864 T DE602004001864 T DE 602004001864T DE 602004001864 D1 DE602004001864 D1 DE 602004001864D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- derivative
- alkyl
- racemates
- tautomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000017442 Retinal disease Diseases 0.000 title 1
- 206010038923 Retinopathy Diseases 0.000 title 1
- 206010003246 arthritis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 3
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HQALDKFFRYFTKP-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-bromo-6-(3-methoxyphenyl)phenoxy]acetic acid Chemical compound COC1=CC=CC(C=2C(=C(Br)C=C(C=2)C=2C=CC(=CC=2)C=2C3=CC=CC=C3SC=2CC=2C=CC=CC=2)OCC(O)=O)=C1 HQALDKFFRYFTKP-UHFFFAOYSA-N 0.000 abstract 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical class C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 1
- 230000002456 anti-arthritic effect Effects 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20030290490 EP1471063A1 (de) | 2003-02-28 | 2003-02-28 | Verbindungen und Methoden zur Behandlung von proliferativen Krankheiten, Retinopathie und Arthritis |
| EP03290490 | 2003-02-28 | ||
| PCT/IB2004/000926 WO2004076445A2 (en) | 2003-02-28 | 2004-02-27 | Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004001864D1 true DE602004001864D1 (de) | 2006-09-21 |
| DE602004001864T2 DE602004001864T2 (de) | 2007-09-06 |
Family
ID=32921633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004001864T Expired - Lifetime DE602004001864T2 (de) | 2003-02-28 | 2004-02-27 | Verbindungen und methoden zur behandlung von proliferativen krankheiten, retinopathie und arthritis |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7514432B2 (de) |
| EP (2) | EP1471063A1 (de) |
| JP (1) | JP4648894B2 (de) |
| CN (1) | CN1747952A (de) |
| AT (1) | ATE335734T1 (de) |
| AU (1) | AU2004215577A1 (de) |
| CA (1) | CA2516239A1 (de) |
| DE (1) | DE602004001864T2 (de) |
| EA (1) | EA200501382A1 (de) |
| WO (1) | WO2004076445A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1471063A1 (de) * | 2003-02-28 | 2004-10-27 | Exonhit Therapeutics S.A. | Verbindungen und Methoden zur Behandlung von proliferativen Krankheiten, Retinopathie und Arthritis |
| US7517890B2 (en) | 2003-11-20 | 2009-04-14 | Children's Hospital Medical Center | GTPase inhibitors and methods of use |
| EP1814553A4 (de) | 2004-11-19 | 2009-10-28 | Childrens Hosp Medical Center | Gtpase-hemmer und deren verwendung zur regulierung von thrombozytenhyperaktivität |
| US20070027146A1 (en) * | 2005-07-27 | 2007-02-01 | Exonhit Therapeutics Sa | Methods of treating nervous disorders |
| CA2617056A1 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| US7801502B2 (en) * | 2006-12-18 | 2010-09-21 | Aai Corporation | Method for implementing continuous radio frequency (RF) alignment in advanced electronic warfare (EW) signal stimulation systems |
| CN101874032B (zh) * | 2007-11-26 | 2013-02-06 | 富山化学工业株式会社 | 二氮杂萘衍生物一水合物及其制备方法 |
| CA2733931A1 (en) * | 2008-08-15 | 2010-02-18 | Burnham Institute For Medical Research | Composition and methods for the design and development of metallo-enzyme inhibitors |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| US8409628B2 (en) | 2010-02-04 | 2013-04-02 | Penguin IP Holdings, Inc. | Methods and compositions for oxygenation of skin to treat skin disorders |
| US8900601B2 (en) | 2010-03-31 | 2014-12-02 | Jennifer Bartels | Permeable mixtures, methods and compositions for the skin |
| US8771682B2 (en) | 2011-04-26 | 2014-07-08 | Technische Universtität Dresden | Methods and compositions for reducing interleukin-4 or interleukin-13 signaling |
| WO2014170712A1 (en) | 2013-04-15 | 2014-10-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Rac-1 inhibitors or pi3k inhibitors for preventing intestinal barrier dysfunction |
| US10155001B2 (en) | 2013-06-14 | 2018-12-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | RAC1 inhibitors for inducing bronchodilation |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| CN105424666B (zh) * | 2015-12-11 | 2018-06-29 | 山东省科学院生物研究所 | 一种快速、定量评价化合物对斑马鱼血管生成促进作用的方法 |
| AR110412A1 (es) * | 2016-12-22 | 2019-03-27 | Orion Corp | Inhibidores de la cyp11a1 |
| WO2019023315A2 (en) | 2017-07-25 | 2019-01-31 | Geneyus LLC | RAC INHIBITORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812584A (en) * | 1984-07-11 | 1989-03-14 | G. D. Searle & Co. | Aralkoxy and aryloxyalkoxy kojic acid derivatives |
| US4644071A (en) * | 1984-07-11 | 1987-02-17 | G. D. Searle & Co. | Aralkoxy and aryloxyalkoxy kojic acid derivatives |
| ZA858493B (en) * | 1984-11-12 | 1986-07-30 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds and process of producing them |
| US6552073B1 (en) * | 2002-03-01 | 2003-04-22 | Exonhit Therapeutics Sa | Compounds and methods of treating cell proliferative diseases |
| EP1471063A1 (de) * | 2003-02-28 | 2004-10-27 | Exonhit Therapeutics S.A. | Verbindungen und Methoden zur Behandlung von proliferativen Krankheiten, Retinopathie und Arthritis |
-
2003
- 2003-02-28 EP EP20030290490 patent/EP1471063A1/de not_active Withdrawn
-
2004
- 2004-02-27 WO PCT/IB2004/000926 patent/WO2004076445A2/en active IP Right Grant
- 2004-02-27 EA EA200501382A patent/EA200501382A1/ru unknown
- 2004-02-27 AT AT04715422T patent/ATE335734T1/de active
- 2004-02-27 EP EP04715422A patent/EP1597253B1/de not_active Expired - Lifetime
- 2004-02-27 US US10/541,328 patent/US7514432B2/en not_active Expired - Fee Related
- 2004-02-27 CN CNA2004800038200A patent/CN1747952A/zh active Pending
- 2004-02-27 DE DE602004001864T patent/DE602004001864T2/de not_active Expired - Lifetime
- 2004-02-27 CA CA002516239A patent/CA2516239A1/en not_active Abandoned
- 2004-02-27 JP JP2006502497A patent/JP4648894B2/ja not_active Expired - Fee Related
- 2004-02-27 AU AU2004215577A patent/AU2004215577A1/en not_active Abandoned
-
2009
- 2009-02-19 US US12/388,828 patent/US20090216014A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060183749A1 (en) | 2006-08-17 |
| EA200501382A1 (ru) | 2006-02-24 |
| US7514432B2 (en) | 2009-04-07 |
| EP1597253B1 (de) | 2006-08-09 |
| WO2004076445A2 (en) | 2004-09-10 |
| CA2516239A1 (en) | 2004-09-10 |
| ATE335734T1 (de) | 2006-09-15 |
| JP4648894B2 (ja) | 2011-03-09 |
| US20090216014A1 (en) | 2009-08-27 |
| WO2004076445A3 (en) | 2005-01-06 |
| JP2006519221A (ja) | 2006-08-24 |
| EP1597253A2 (de) | 2005-11-23 |
| AU2004215577A1 (en) | 2004-09-10 |
| DE602004001864T2 (de) | 2007-09-06 |
| EP1471063A1 (de) | 2004-10-27 |
| CN1747952A (zh) | 2006-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |