DE60135022D1 - Antitumoraktivität zeigendes runx3-gen und dessen verwendung - Google Patents

Antitumoraktivität zeigendes runx3-gen und dessen verwendung

Info

Publication number
DE60135022D1
DE60135022D1 DE60135022T DE60135022T DE60135022D1 DE 60135022 D1 DE60135022 D1 DE 60135022D1 DE 60135022 T DE60135022 T DE 60135022T DE 60135022 T DE60135022 T DE 60135022T DE 60135022 D1 DE60135022 D1 DE 60135022D1
Authority
DE
Germany
Prior art keywords
runx3
development
gene
cancer
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60135022T
Other languages
English (en)
Inventor
Suk-Chul Bae
Yoshiaki Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60135022D1 publication Critical patent/DE60135022D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE60135022T 2001-01-29 2001-01-30 Antitumoraktivität zeigendes runx3-gen und dessen verwendung Expired - Lifetime DE60135022D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2001-0004018A KR100475649B1 (ko) 2001-01-29 2001-01-29 항암활성을 나타내는 ｒｕｎｘ３ 유전자 및 그의 용도
PCT/KR2001/000121 WO2002061069A1 (en) 2001-01-29 2001-01-30 Runx3 gene showing anti-tumor activity and use thereof

Publications (1)

Publication Number Publication Date
DE60135022D1 true DE60135022D1 (de) 2008-09-04

Family

ID=19705043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60135022T Expired - Lifetime DE60135022D1 (de) 2001-01-29 2001-01-30 Antitumoraktivität zeigendes runx3-gen und dessen verwendung

Country Status (10)

Country Link
US (2) US7368255B2 (de)
EP (1) EP1356030B1 (de)
JP (1) JP4018542B2 (de)
KR (1) KR100475649B1 (de)
AT (1) ATE402256T1 (de)
DE (1) DE60135022D1 (de)
DK (1) DK1356030T3 (de)
ES (1) ES2310545T3 (de)
PT (1) PT1356030E (de)
WO (1) WO2002061069A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
WO2005040814A1 (en) * 2003-10-14 2005-05-06 Cancer Research Technology Limited Methods and means of cancer detection by histone modification
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006057623A1 (en) * 2004-11-29 2006-06-01 National University Of Singapore Runx3 antibodies and method of obtaining the antibodies
KR100748185B1 (ko) * 2005-01-31 2007-08-10 한국생명공학연구원 Ｌｒｒｃ3ｂ 유전자를 포함하는 항암용 조성물 및 상기유전자를 이용한 진단방법
US8268572B2 (en) * 2005-03-04 2012-09-18 Dana-Farber Cancer Institute, Inc. Methods to identify inhibitors of Runx1-mediated expression of nociceptive receptors and ion channels
US7611847B2 (en) 2005-06-01 2009-11-03 Agency For Science, Technology And Research Method for identifying an intestinal phenotype
WO2006132248A1 (ja) * 2005-06-07 2006-12-14 Daiichi Pharmaceutical Co., Ltd. Ｒｕｎｘのユビキチン化方法
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
EP2004860A4 (de) * 2006-03-29 2009-12-30 Wayne John Cancer Inst Methylierung von östrogenrezeptor-alpha und verwendung
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2481815B1 (de) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US9322065B2 (en) 2007-09-17 2016-04-26 Mdxhealth Sa Methods for determining methylation of the TWIST1 gene for bladder cancer detection
KR20100093523A (ko) * 2007-11-06 2010-08-25 주식회사 프로셀제약 세포투과성 ｒｕｎｘ３ 재조합 단백질, 이를 코딩하는 폴리뉴클레오티드 및 이를 유효성분으로 함유하는 항암 조성물
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP2320917A4 (de) * 2008-07-29 2011-11-09 Agency Science Tech & Res Verfahren zur prävention, hemmung oder umkehrung von tumorgenese und zur identifzierung von verbindungen dafür
EP3808177A1 (de) * 2008-11-10 2021-04-21 Arbutus Biopharma Corporation Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR101878451B1 (ko) * 2011-09-06 2018-07-16 벤텍스 주식회사 약물전달기능을 갖는 언더웨어
EP2823303A4 (de) 2012-02-10 2015-09-30 Raindance Technologies Inc Molekulardiagnostischer screeningtest
WO2013165748A1 (en) 2012-04-30 2013-11-07 Raindance Technologies, Inc Digital analyte analysis
WO2014113406A1 (en) * 2013-01-15 2014-07-24 Fred Hutchinson Cancer Research Center Compositions and methods for treating pancreatic cancer
EP2986762B1 (de) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digitale analyse von analyten
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN106011263B (zh) * 2016-06-28 2020-01-07 宁波大学 用于检测与胃癌相关的ndrg4基因甲基化程度的试剂盒及其应用
CA3035882A1 (en) 2016-07-29 2018-02-01 Kyoto University Runx inhibitor
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
KR101994957B1 (ko) 2017-11-30 2019-07-01 고려대학교 산학협력단 Runx3 단백질 또는 이를 코딩하는 runx3 유전자를 포함하는 trail의 항암 효과 증진용 약학 조성물
WO2019210863A1 (zh) * 2018-05-03 2019-11-07 科济生物医药（上海）有限公司 免疫效应细胞及其应用
JP7144037B2 (ja) * 2018-07-25 2022-09-29 国立大学法人山口大学 がんの診断用バイオマーカー
US20220088126A1 (en) * 2019-01-08 2022-03-24 Biorunx Pharmaceutical composition comprising runx3 gene or protein as active ingredient for prevention or treatment of k-ras mutant lung cancer
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
KR20210131855A (ko) * 2020-04-23 2021-11-03 런엑스 주식회사 R-point 조절 단백질 복합체를 유효성분으로 포함하는 폐암 치료용 약학적 조성물, 상기 복합체의 형성 여부를 이용한 폐암 치료제 스크리닝 방법 및 폐암 진단 방법

Also Published As

Publication number Publication date
WO2002061069A1 (en) 2002-08-08
EP1356030B1 (de) 2008-07-23
US20080261883A1 (en) 2008-10-23
JP4018542B2 (ja) 2007-12-05
JP2004529619A (ja) 2004-09-30
KR100475649B1 (ko) 2005-03-10
ATE402256T1 (de) 2008-08-15
EP1356030A1 (de) 2003-10-29
EP1356030A4 (de) 2005-02-02
US20040146986A1 (en) 2004-07-29
ES2310545T3 (es) 2009-01-16
PT1356030E (pt) 2008-10-30
KR20020063387A (ko) 2002-08-03
US7368255B2 (en) 2008-05-06
DK1356030T3 (da) 2008-11-03

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