DE60133317T2 - System für die elektrokinetische freisetzung einer substanz - Google Patents
System für die elektrokinetische freisetzung einer substanz Download PDFInfo
- Publication number
- DE60133317T2 DE60133317T2 DE60133317T DE60133317T DE60133317T2 DE 60133317 T2 DE60133317 T2 DE 60133317T2 DE 60133317 T DE60133317 T DE 60133317T DE 60133317 T DE60133317 T DE 60133317T DE 60133317 T2 DE60133317 T2 DE 60133317T2
- Authority
- DE
- Germany
- Prior art keywords
- electrodes
- current
- electrode
- substance
- power source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims abstract description 21
- 230000000694 effects Effects 0.000 claims abstract 2
- 238000011282 treatment Methods 0.000 claims description 36
- 239000003814 drug Substances 0.000 claims description 26
- 241001465754 Metazoa Species 0.000 claims description 4
- 230000002457 bidirectional effect Effects 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 24
- 210000001519 tissue Anatomy 0.000 description 20
- 239000010410 layer Substances 0.000 description 14
- 208000003663 ventricular fibrillation Diseases 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 2
- 206010019973 Herpes virus infection Diseases 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- XCKKIKBIPZJUET-VYKNHSEDSA-N morphine hydrochloride Chemical compound Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O XCKKIKBIPZJUET-VYKNHSEDSA-N 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- -1 morphine HCl ions Chemical class 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/013431 WO2002087691A1 (en) | 2001-04-27 | 2001-04-27 | Method and system for electrokinetic delivery of a substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60133317D1 DE60133317D1 (de) | 2008-04-30 |
| DE60133317T2 true DE60133317T2 (de) | 2009-03-05 |
Family
ID=21742534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60133317T Expired - Lifetime DE60133317T2 (de) | 2001-04-27 | 2001-04-27 | System für die elektrokinetische freisetzung einer substanz |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1390099B1 (https=) |
| JP (1) | JP4303476B2 (https=) |
| CN (1) | CN100490919C (https=) |
| AT (1) | ATE389435T1 (https=) |
| BR (1) | BR0116990A (https=) |
| CA (1) | CA2445414A1 (https=) |
| DE (1) | DE60133317T2 (https=) |
| DK (1) | DK1390099T3 (https=) |
| ES (1) | ES2301540T3 (https=) |
| MX (1) | MXPA03009743A (https=) |
| WO (1) | WO2002087691A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888641B (zh) * | 2019-05-06 | 2023-09-22 | 上海肤泰科技有限公司 | 离子电渗透的给药装置 |
| JP7572159B2 (ja) * | 2020-04-22 | 2024-10-23 | ヤーマン株式会社 | 美容器 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US594684A (en) * | 1897-11-30 | dustin | ||
| CH567424A5 (https=) * | 1973-11-26 | 1975-10-15 | Wyss Oscar A M | |
| US5042975A (en) * | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
| US5961482A (en) * | 1986-07-25 | 1999-10-05 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
| EP0398960B1 (en) * | 1988-01-21 | 1995-12-06 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| US5135478A (en) * | 1989-05-10 | 1992-08-04 | Drug Delivery Systems Inc. | Multi-signal electrical transdermal drug applicator |
| FR2709670B1 (fr) * | 1993-09-10 | 1995-10-20 | Asulab Sa | Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse. |
| CA2172991A1 (en) * | 1993-09-30 | 1995-04-06 | Burton H. Sage, Jr. | Iontophoretic drug delivery system and method |
| US5551953A (en) * | 1994-10-31 | 1996-09-03 | Alza Corporation | Electrotransport system with remote telemetry link |
| US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
-
2001
- 2001-04-27 JP JP2002585030A patent/JP4303476B2/ja not_active Expired - Fee Related
- 2001-04-27 MX MXPA03009743A patent/MXPA03009743A/es active IP Right Grant
- 2001-04-27 DK DK01930784T patent/DK1390099T3/da active
- 2001-04-27 CA CA002445414A patent/CA2445414A1/en not_active Abandoned
- 2001-04-27 DE DE60133317T patent/DE60133317T2/de not_active Expired - Lifetime
- 2001-04-27 AT AT01930784T patent/ATE389435T1/de not_active IP Right Cessation
- 2001-04-27 EP EP01930784A patent/EP1390099B1/en not_active Expired - Lifetime
- 2001-04-27 WO PCT/US2001/013431 patent/WO2002087691A1/en not_active Ceased
- 2001-04-27 CN CNB018231918A patent/CN100490919C/zh not_active Expired - Fee Related
- 2001-04-27 BR BR0116990-4A patent/BR0116990A/pt not_active Application Discontinuation
- 2001-04-27 ES ES01930784T patent/ES2301540T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN100490919C (zh) | 2009-05-27 |
| EP1390099A1 (en) | 2004-02-25 |
| CA2445414A1 (en) | 2002-11-07 |
| JP4303476B2 (ja) | 2009-07-29 |
| WO2002087691A1 (en) | 2002-11-07 |
| CN1505536A (zh) | 2004-06-16 |
| ES2301540T3 (es) | 2008-07-01 |
| EP1390099A4 (en) | 2005-09-21 |
| HK1062414A1 (en) | 2004-11-05 |
| ATE389435T1 (de) | 2008-04-15 |
| DE60133317D1 (de) | 2008-04-30 |
| DK1390099T3 (da) | 2008-06-09 |
| BR0116990A (pt) | 2004-03-02 |
| EP1390099B1 (en) | 2008-03-19 |
| MXPA03009743A (es) | 2004-06-30 |
| JP2004525724A (ja) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |