DE60132474T2 - Ein immunostimulierendes nukleotid und ein tocol enthaltende zusammensetzung - Google Patents
Ein immunostimulierendes nukleotid und ein tocol enthaltende zusammensetzung Download PDFInfo
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- DE60132474T2 DE60132474T2 DE60132474T DE60132474T DE60132474T2 DE 60132474 T2 DE60132474 T2 DE 60132474T2 DE 60132474 T DE60132474 T DE 60132474T DE 60132474 T DE60132474 T DE 60132474T DE 60132474 T2 DE60132474 T2 DE 60132474T2
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- tocol
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0025577.8A GB0025577D0 (en) | 2000-10-18 | 2000-10-18 | Vaccine |
| GB0025577 | 2000-10-18 | ||
| PCT/EP2001/011985 WO2002032454A1 (en) | 2000-10-18 | 2001-10-16 | Adjuvant composition comprising an immunostimulatory oligonucleotide and a tocol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132474D1 DE60132474D1 (de) | 2008-03-06 |
| DE60132474T2 true DE60132474T2 (de) | 2009-01-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132474T Expired - Lifetime DE60132474T2 (de) | 2000-10-18 | 2001-10-16 | Ein immunostimulierendes nukleotid und ein tocol enthaltende zusammensetzung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20040047869A1 (xx) |
| EP (1) | EP1326639B1 (xx) |
| JP (1) | JP2004511529A (xx) |
| KR (1) | KR20030044016A (xx) |
| CN (1) | CN100346829C (xx) |
| AT (1) | ATE383872T1 (xx) |
| AU (2) | AU2168902A (xx) |
| BR (1) | BR0114785A (xx) |
| CA (1) | CA2425310A1 (xx) |
| CZ (1) | CZ20031094A3 (xx) |
| DE (1) | DE60132474T2 (xx) |
| ES (1) | ES2299530T3 (xx) |
| GB (1) | GB0025577D0 (xx) |
| HU (1) | HUP0303720A3 (xx) |
| IL (1) | IL155283A0 (xx) |
| MX (1) | MXPA03003406A (xx) |
| NO (1) | NO20031646L (xx) |
| NZ (1) | NZ525321A (xx) |
| PL (1) | PL365322A1 (xx) |
| WO (1) | WO2002032454A1 (xx) |
| ZA (1) | ZA200302887B (xx) |
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| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| ES2572834T3 (es) | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
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| BR0210628A (pt) * | 2001-06-29 | 2004-08-10 | Becton Dickinson Co | Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula |
| DK1446162T3 (da) * | 2001-08-17 | 2008-12-08 | Coley Pharm Gmbh | Kombinationsmotiv-immunstimulatoriske oligonukleotider med forbedret aktivitet |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
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| US20040053880A1 (en) * | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
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| US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| BR0312273A (pt) * | 2002-07-10 | 2005-04-26 | Akzo Nobel Nv | Composição imunogênica, vacina, método para a preparação da mesma, e, uso de uma composição imunogênica |
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| US20040235770A1 (en) * | 2003-04-02 | 2004-11-25 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations and related methods of use |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
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| US20080032384A1 (en) * | 2004-04-22 | 2008-02-07 | Takehiko Nomura | Pharmaceutical Preparation Containing Bacterial Cell Wall Skeleton |
| KR100958505B1 (ko) * | 2004-07-18 | 2010-05-17 | 씨에스엘 리미티드 | 면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기위한 올리고뉴클레오티드 제제 |
| AR052625A1 (es) | 2005-03-23 | 2007-03-21 | Glaxosmithkline Biolog Sa | Nueva composicion |
| KR100740237B1 (ko) * | 2005-05-10 | 2007-07-18 | 아이진 주식회사 | 올리고뉴클레오타이드 및 비독성 다당체를 포함하는면역보조제 |
| CN101268101A (zh) * | 2005-07-07 | 2008-09-17 | 科利制药集团公司 | 用于癌症治疗的抗-CTLA-4抗体和含有CpG基序的合成寡脱氧核苷酸联合治疗 |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| US10842867B2 (en) | 2005-11-04 | 2020-11-24 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CA2628397C (en) * | 2005-11-04 | 2013-08-20 | Novartis Vaccines And Diagnostics S.R.L. | Changing th1/th2 balance in split influenza vaccines with adjuvants |
| TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
| DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
| AU2007280690C1 (en) | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
| CA2662921C (en) * | 2006-09-26 | 2018-11-20 | Infectious Disease Research Institute | Vaccine and pharmaceutical compositions and kits and uses thereof in stimulating an immune response with a synthetic glucopyranosyl lipid adjuvant |
| NZ575437A (en) | 2006-09-27 | 2012-02-24 | Coley Pharm Gmbh | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
| DK2086582T3 (da) * | 2006-10-12 | 2013-02-04 | Glaxosmithkline Biolog Sa | Vaccine omfattende en olie-i-vand-emulsionsadjuvans |
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| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| ES2537703T3 (es) | 2008-01-31 | 2015-06-11 | Curevac Gmbh | Ácidos nucleicos que comprenden la fórmula (NuGlXmGnNv)a y sus derivados como agentes/adyuvantes inmunoestimuladores |
| DK3056214T3 (da) | 2008-06-27 | 2019-05-13 | Zoetis Services Llc | Hidtil ukendte adjuvanssammensætninger |
| EP2328614A1 (en) * | 2008-08-06 | 2011-06-08 | Novartis AG | Microparticles for use in immunogenic compositions |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| AU2011285200B2 (en) | 2010-07-30 | 2014-08-21 | CureVac SE | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| WO2013173590A1 (en) | 2012-05-16 | 2013-11-21 | Immune Design Corp. | Vaccines for hsv-2 |
| EA032326B1 (ru) | 2013-04-18 | 2019-05-31 | Иммьюн Дизайн Корп. | Монотерапия gla для применения в лечении рака |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| BR112016005948A2 (pt) | 2013-09-19 | 2017-09-26 | Zoetis Services Llc | adjuvantes com base em óleo |
| CA2936286A1 (en) | 2014-04-01 | 2015-10-08 | Curevac Ag | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
| HUE063288T2 (hu) | 2015-01-16 | 2024-01-28 | Zoetis Services Llc | Száj és körömfájás betegség vakcina |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69015222T2 (de) * | 1989-02-04 | 1995-05-04 | Akzo Nv | Tocole als Impfstoffadjuvans. |
| GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| DK1187629T3 (da) * | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
-
2000
- 2000-10-18 GB GBGB0025577.8A patent/GB0025577D0/en not_active Ceased
-
2001
- 2001-10-16 ES ES01987673T patent/ES2299530T3/es not_active Expired - Lifetime
- 2001-10-16 EP EP01987673A patent/EP1326639B1/en not_active Expired - Lifetime
- 2001-10-16 HU HU0303720A patent/HUP0303720A3/hu unknown
- 2001-10-16 CZ CZ20031094A patent/CZ20031094A3/cs unknown
- 2001-10-16 CA CA002425310A patent/CA2425310A1/en not_active Abandoned
- 2001-10-16 BR BR0114785-4A patent/BR0114785A/pt not_active Withdrawn
- 2001-10-16 AT AT01987673T patent/ATE383872T1/de not_active IP Right Cessation
- 2001-10-16 US US10/399,356 patent/US20040047869A1/en not_active Abandoned
- 2001-10-16 DE DE60132474T patent/DE60132474T2/de not_active Expired - Lifetime
- 2001-10-16 JP JP2002535691A patent/JP2004511529A/ja active Pending
- 2001-10-16 KR KR10-2003-7005466A patent/KR20030044016A/ko not_active Application Discontinuation
- 2001-10-16 IL IL15528301A patent/IL155283A0/xx unknown
- 2001-10-16 NZ NZ525321A patent/NZ525321A/en unknown
- 2001-10-16 PL PL01365322A patent/PL365322A1/xx unknown
- 2001-10-16 AU AU2168902A patent/AU2168902A/xx active Pending
- 2001-10-16 WO PCT/EP2001/011985 patent/WO2002032454A1/en active IP Right Grant
- 2001-10-16 MX MXPA03003406A patent/MXPA03003406A/es unknown
- 2001-10-16 AU AU2002221689A patent/AU2002221689B2/en not_active Ceased
- 2001-10-16 CN CNB018206603A patent/CN100346829C/zh not_active Expired - Fee Related
-
2003
- 2003-04-10 NO NO20031646A patent/NO20031646L/no not_active Application Discontinuation
- 2003-04-11 ZA ZA200302887A patent/ZA200302887B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002221689B2 (en) | 2004-04-01 |
| EP1326639A1 (en) | 2003-07-16 |
| ES2299530T3 (es) | 2008-06-01 |
| MXPA03003406A (es) | 2005-01-25 |
| JP2004511529A (ja) | 2004-04-15 |
| ZA200302887B (en) | 2004-07-12 |
| GB0025577D0 (en) | 2000-12-06 |
| DE60132474D1 (de) | 2008-03-06 |
| NO20031646L (no) | 2003-06-14 |
| CZ20031094A3 (cs) | 2003-09-17 |
| AU2168902A (en) | 2002-04-29 |
| US20040047869A1 (en) | 2004-03-11 |
| CN100346829C (zh) | 2007-11-07 |
| CA2425310A1 (en) | 2002-04-25 |
| KR20030044016A (ko) | 2003-06-02 |
| CN1481254A (zh) | 2004-03-10 |
| BR0114785A (pt) | 2003-12-23 |
| HUP0303720A2 (hu) | 2004-03-29 |
| ATE383872T1 (de) | 2008-02-15 |
| PL365322A1 (en) | 2004-12-27 |
| WO2002032454A1 (en) | 2002-04-25 |
| EP1326639B1 (en) | 2008-01-16 |
| NZ525321A (en) | 2004-06-25 |
| IL155283A0 (en) | 2003-11-23 |
| NO20031646D0 (no) | 2003-04-10 |
| HUP0303720A3 (en) | 2004-11-29 |
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