DE60131760T2 - Vorrichtung zur verabreichung von physiologisch aktiven wirkstoffen in pulverform - Google Patents
Vorrichtung zur verabreichung von physiologisch aktiven wirkstoffen in pulverform Download PDFInfo
- Publication number
- DE60131760T2 DE60131760T2 DE60131760T DE60131760T DE60131760T2 DE 60131760 T2 DE60131760 T2 DE 60131760T2 DE 60131760 T DE60131760 T DE 60131760T DE 60131760 T DE60131760 T DE 60131760T DE 60131760 T2 DE60131760 T2 DE 60131760T2
- Authority
- DE
- Germany
- Prior art keywords
- powder
- reservoir
- air
- indexing
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000843 powder Substances 0.000 title claims description 188
- 230000033001 locomotion Effects 0.000 claims description 28
- 230000007246 mechanism Effects 0.000 claims description 17
- 239000013543 active substance Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 230000008878 coupling Effects 0.000 claims description 9
- 238000010168 coupling process Methods 0.000 claims description 9
- 238000005859 coupling reaction Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 210000003928 nasal cavity Anatomy 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- 229960000074 biopharmaceutical Drugs 0.000 claims description 2
- 210000000078 claw Anatomy 0.000 claims description 2
- 238000001415 gene therapy Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 1
- 238000001647 drug administration Methods 0.000 claims 1
- 239000003570 air Substances 0.000 description 73
- 238000011144 upstream manufacturing Methods 0.000 description 21
- 125000006850 spacer group Chemical group 0.000 description 16
- 238000012377 drug delivery Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000006835 compression Effects 0.000 description 6
- 238000007906 compression Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 230000002996 emotional effect Effects 0.000 description 3
- 210000001331 nose Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0075—Bellows-type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/075—Bulb type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0019715.2A GB0019715D0 (en) | 2000-08-10 | 2000-08-10 | Device for delivering physiologically active agent in powdered form |
| GB0019715 | 2000-08-10 | ||
| PCT/GB2001/003555 WO2002011800A2 (en) | 2000-08-10 | 2001-08-08 | Device for delivering physiologically active agent in powdered form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60131760D1 DE60131760D1 (de) | 2008-01-17 |
| DE60131760T2 true DE60131760T2 (de) | 2008-11-13 |
Family
ID=9897388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60131760T Expired - Fee Related DE60131760T2 (de) | 2000-08-10 | 2001-08-08 | Vorrichtung zur verabreichung von physiologisch aktiven wirkstoffen in pulverform |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7275537B2 (enExample) |
| EP (1) | EP1322356B1 (enExample) |
| JP (1) | JP2004509669A (enExample) |
| AU (2) | AU2001276538B2 (enExample) |
| CA (1) | CA2418906A1 (enExample) |
| DE (1) | DE60131760T2 (enExample) |
| ES (1) | ES2295187T3 (enExample) |
| GB (1) | GB0019715D0 (enExample) |
| WO (1) | WO2002011800A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6082358A (en) | 1998-05-05 | 2000-07-04 | 1263152 Ontario Inc. | Indicating device for aerosol container |
| GB0216556D0 (en) * | 2002-07-17 | 2002-08-28 | Reckitt Benckiser Uk Ltd | Dispenser |
| GB0303870D0 (en) * | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
| FI20031158L (fi) * | 2003-08-15 | 2005-02-16 | Perlos Oyj | Inhalaattori |
| FR2881117B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| FR2881118B1 (fr) * | 2005-01-25 | 2007-04-20 | Valois Sas | Dispositif de distribution de produit fluide. |
| TWI442951B (zh) * | 2005-04-14 | 2014-07-01 | Astrazeneca Ab | 吸入器計量器 |
| US7614429B2 (en) | 2005-05-18 | 2009-11-10 | Symyx Solutions, Inc. | Apparatus and methods for storing and dispensing solid material |
| JP4500280B2 (ja) * | 2005-06-08 | 2010-07-14 | 日立オートモティブシステムズ株式会社 | 粉末薬剤投与器 |
| GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| DE102006043637A1 (de) * | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zerstäuber |
| US20080035143A1 (en) * | 2006-08-14 | 2008-02-14 | Sievers Robert E | Human-powered dry powder inhaler and dry powder inhaler compositions |
| EP2112923A1 (en) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| GB0704928D0 (en) * | 2007-03-14 | 2007-04-25 | Cambridge Consultants | Dry powder inhalers |
| EP2042208A1 (en) * | 2007-09-25 | 2009-04-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| EP2082759A1 (en) † | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| US20100127022A1 (en) * | 2008-11-21 | 2010-05-27 | Symyx Technologies, Inc. | Dispensing valve |
| BRPI1009072B1 (pt) | 2009-05-18 | 2021-06-22 | Adamis Pharmaceuticals Corporation | Dispositivo para inalação de pó seco e dispositivo para armazenamento de pó seco |
| AT13748U1 (de) * | 2013-05-29 | 2014-08-15 | Boehringer Ingelheim Int | Zerstäuber |
| US10507293B2 (en) | 2015-06-24 | 2019-12-17 | Ethicon, Inc. | Hemostatic powder delivery devices and methods |
| WO2017118962A1 (en) * | 2016-01-08 | 2017-07-13 | Inertia Engineering + Design Inc. | Portable electromechanical resuscitator bag compression device |
| CA3182156A1 (en) | 2020-05-08 | 2021-11-11 | Psilera Inc. | Novel compositions of matter and pharmaceutical compositions |
| EP4347562A4 (en) | 2021-05-25 | 2025-04-30 | ATAI Therapeutics, Inc. | NEW SALTS OF N,N-DIMETHYLTRYPTAMINE AND NEW CRYSTALLINE SALT FORMS |
| WO2022261383A1 (en) | 2021-06-09 | 2022-12-15 | ATAI Life Sciences AG | Novel prodrugs and conjugates of dimethyltryptamine |
| US12012381B2 (en) | 2021-12-30 | 2024-06-18 | Atai Therapeutics, Inc. | Dimethyltryptamine analogues as nitric oxide delivery drugs |
| MX2024008691A (es) | 2022-01-14 | 2024-07-19 | Cybin Irl Ltd | Composiciones y metodos de triptamina. |
| CA3244130A1 (en) | 2022-02-15 | 2023-08-24 | Cybin Irl Ltd | PHENETYLAMINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE |
| EP4479373A1 (en) | 2022-02-15 | 2024-12-25 | Cybin IRL Limited | Therapeutic phenethylamine compositions and methods of use |
| JP2025510942A (ja) | 2022-03-31 | 2025-04-15 | サイビン アイアールエル リミテッド | 亜酸化窒素及び５－ｈｔ２ａ受容体作動薬の組み合わせ |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1479283A (en) * | 1973-07-23 | 1977-07-13 | Bespak Industries Ltd | Inhaler for powdered medicament |
| US4274403A (en) * | 1979-08-29 | 1981-06-23 | Struve Roger L | Inhaler |
| GB8810898D0 (en) | 1988-05-09 | 1988-06-15 | Bespak Plc | Improvements in dispensing apparatus |
| GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| DE4027749A1 (de) * | 1990-09-01 | 1992-03-05 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| ATE209938T1 (de) | 1990-09-26 | 2001-12-15 | Pharmachemie Bv | Wirbelkammer-pulverinhalator |
| WO1992006727A1 (en) | 1990-10-12 | 1992-04-30 | Novo Nordisk A/S | Disposable dispenser for powder |
| GB2251898A (en) | 1990-11-29 | 1992-07-22 | D M W | Metered dose spray system |
| US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
| JPH06504223A (ja) | 1991-08-15 | 1994-05-19 | デル・ボン・フランコ | 吸入器 |
| GB9123953D0 (en) | 1991-11-12 | 1992-01-02 | Minnesota Mining & Mfg | Inhalation device |
| GB9203761D0 (en) * | 1992-02-21 | 1992-04-08 | Innovata Biomed Ltd | Inhaler |
| GB9218937D0 (en) | 1992-09-08 | 1992-10-21 | Norton Healthcare Ltd | Medicament dispensing device |
| EP0668787B1 (en) * | 1992-11-12 | 2002-02-27 | Minnesota Mining And Manufacturing Company | Powder inhaler |
| UA27961C2 (uk) * | 1992-12-18 | 2000-10-16 | Шерінг Корпорейшн | Інгалятор для порошкових ліків |
| DE4227899A1 (de) * | 1993-09-24 | 1994-02-24 | Pfeiffer Erich Gmbh & Co Kg | Austrageeinrichtung für fließfähige Medien |
| US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| DE19518810A1 (de) * | 1995-05-26 | 1996-11-28 | Bayer Ag | Nasal-Applikator |
| JPH1028735A (ja) | 1996-05-11 | 1998-02-03 | Unisia Jecs Corp | 鼻腔用投薬器 |
| GB9700226D0 (en) | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
| GB9702688D0 (en) | 1997-02-10 | 1997-04-02 | Bespak Plc | A dispensing apparatus |
| HU224242B1 (hu) * | 1998-01-30 | 2005-06-28 | IG Sprühtechnik GmbH & Co. KG | Inhaláló por alakú gyógyszerekhez |
| GB9820900D0 (en) * | 1998-09-26 | 1998-11-18 | Glaxo Group Ltd | Inhalation device |
| KR20020035885A (ko) * | 1999-10-06 | 2002-05-15 | 샤를로트 멍크 | 테이프를 코일상으로 권취하여 초전도체 테이프를 제조 및사용하는 방법 |
| EP1220698B1 (en) * | 1999-10-12 | 2004-07-21 | SHL Medical AB | Inhaler |
| US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
| GB0015034D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Inhalation device |
| WO2005018087A2 (en) | 2003-07-28 | 2005-02-24 | Qualcomm Incorporated | Procedure for estimating a frequency shift parameter of an oscillator |
-
2000
- 2000-08-10 GB GBGB0019715.2A patent/GB0019715D0/en not_active Ceased
-
2001
- 2001-08-08 AU AU2001276538A patent/AU2001276538B2/en not_active Ceased
- 2001-08-08 DE DE60131760T patent/DE60131760T2/de not_active Expired - Fee Related
- 2001-08-08 EP EP01954194A patent/EP1322356B1/en not_active Expired - Lifetime
- 2001-08-08 AU AU7653801A patent/AU7653801A/xx active Pending
- 2001-08-08 WO PCT/GB2001/003555 patent/WO2002011800A2/en not_active Ceased
- 2001-08-08 JP JP2002517132A patent/JP2004509669A/ja active Pending
- 2001-08-08 CA CA002418906A patent/CA2418906A1/en not_active Abandoned
- 2001-08-08 US US10/344,130 patent/US7275537B2/en not_active Expired - Fee Related
- 2001-08-08 ES ES01954194T patent/ES2295187T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001276538C1 (en) | 2002-02-18 |
| ES2295187T3 (es) | 2008-04-16 |
| EP1322356A1 (en) | 2003-07-02 |
| CA2418906A1 (en) | 2002-02-14 |
| AU2001276538B2 (en) | 2006-08-10 |
| US7275537B2 (en) | 2007-10-02 |
| WO2002011800A2 (en) | 2002-02-14 |
| JP2004509669A (ja) | 2004-04-02 |
| DE60131760D1 (de) | 2008-01-17 |
| AU7653801A (en) | 2002-02-18 |
| EP1322356B1 (en) | 2007-12-05 |
| GB0019715D0 (en) | 2000-09-27 |
| US20030183230A1 (en) | 2003-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |