DE60130659T2 - Therapeutische verbindungen und verfahren - Google Patents

Therapeutische verbindungen und verfahren Download PDF

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Publication number
DE60130659T2
DE60130659T2 DE60130659T DE60130659T DE60130659T2 DE 60130659 T2 DE60130659 T2 DE 60130659T2 DE 60130659 T DE60130659 T DE 60130659T DE 60130659 T DE60130659 T DE 60130659T DE 60130659 T2 DE60130659 T2 DE 60130659T2
Authority
DE
Germany
Prior art keywords
optionally substituted
compound
cells
cyclic
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60130659T
Other languages
German (de)
English (en)
Other versions
DE60130659D1 (de
Inventor
Barbara Martha Gisborne MEURER-GRIMES
Jin Balwyn YU
Gino Luigi Northcote VAIRO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of State of Sarawak Malaysia Kuching
Sarawak Government of State of Malaysia
Original Assignee
Government of State of Sarawak Malaysia Kuching
Sarawak Government of State of Malaysia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of State of Sarawak Malaysia Kuching, Sarawak Government of State of Malaysia filed Critical Government of State of Sarawak Malaysia Kuching
Publication of DE60130659D1 publication Critical patent/DE60130659D1/de
Application granted granted Critical
Publication of DE60130659T2 publication Critical patent/DE60130659T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/121,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60130659T 2000-07-05 2001-07-05 Therapeutische verbindungen und verfahren Expired - Lifetime DE60130659T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPQ8665A AUPQ866500A0 (en) 2000-07-05 2000-07-05 Therapeutic compounds and methods
AUPP866500 2000-07-05
PCT/AU2001/000810 WO2002002566A1 (en) 2000-07-05 2001-07-05 Therapeutic compounds and methods

Publications (2)

Publication Number Publication Date
DE60130659D1 DE60130659D1 (de) 2007-11-08
DE60130659T2 true DE60130659T2 (de) 2008-07-17

Family

ID=3822729

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60130659T Expired - Lifetime DE60130659T2 (de) 2000-07-05 2001-07-05 Therapeutische verbindungen und verfahren

Country Status (10)

Country Link
US (1) US6710075B2 (https=)
EP (1) EP1303520B1 (https=)
JP (1) JP2004501983A (https=)
AT (1) ATE374203T1 (https=)
AU (1) AUPQ866500A0 (https=)
CA (1) CA2411818C (https=)
DE (1) DE60130659T2 (https=)
ES (1) ES2295176T3 (https=)
PT (1) PT1303520E (https=)
WO (1) WO2002002566A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2504999A1 (en) * 2002-11-08 2004-05-21 The Government Of The State Of Sarawak, Malaysia Therapeutic compounds and methods
WO2006007634A1 (en) * 2004-07-16 2006-01-26 Cerylid Biosciences Ltd Processes and intermediates
EP2189158A1 (en) 2008-11-20 2010-05-26 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer
WO2011140334A2 (en) * 2010-05-06 2011-11-10 Trustees Of Boston University Compounds, methods of making or identifying compounds, and uses thereof
FR3023290B1 (fr) * 2014-07-04 2016-08-19 Pf Medicament Derives de flavaglines
WO2017214024A1 (en) 2016-06-06 2017-12-14 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
KR20200123184A (ko) 2018-02-19 2020-10-28 메모리얼 슬로안 케터링 캔서 센터 증식이상 장애를 치료하기 위한 물질 및 방법
CN110279687A (zh) * 2019-07-15 2019-09-27 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种抗肿瘤药物
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
MY194199A (en) * 2020-08-11 2022-11-21 The Government Of The State Of Sarawak Malaysia A composition for the treatment of autoimmune diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656296A (en) 1983-06-01 1987-04-07 Sun Chemical Corporation Novel compounds and their use as insolubilizers for binders for paper coating compositions
IL114758A0 (en) 1994-08-04 1995-11-27 Ciba Geigy Ag Insecticidal polycyclic compounds
JPH0967360A (ja) 1995-08-28 1997-03-11 Terumo Corp 癌遺伝子機能抑制剤
WO1997008161A1 (en) 1995-08-28 1997-03-06 Terumo Kabushiki Kaisha Oncogene function depressant
JPH1112279A (ja) 1997-06-27 1999-01-19 Microbial Chem Res Found Ras蛋白の阻害活性を有する新規なアグライアスタチン立体異性体とそれらの製造法
DE19934952A1 (de) * 1998-07-30 2000-02-03 Novartis Ag Cyclopentabenzofuran-Derivate
DE19835324A1 (de) 1998-08-05 2000-02-10 Bayer Ag Cyclopentabenzofuran-Derivate und ihre Verwendung
DE19835325A1 (de) * 1998-08-05 2000-02-10 Bayer Ag Verwendung von Cyclopentabenzofuran-Derivaten zur Bekämpfung von NF-kB abhängigen Krankheiten

Also Published As

Publication number Publication date
DE60130659D1 (de) 2007-11-08
EP1303520A1 (en) 2003-04-23
US6710075B2 (en) 2004-03-23
PT1303520E (pt) 2008-01-07
ES2295176T3 (es) 2008-04-16
CA2411818C (en) 2011-02-22
EP1303520A4 (en) 2005-03-30
ATE374203T1 (de) 2007-10-15
JP2004501983A (ja) 2004-01-22
WO2002002566A1 (en) 2002-01-10
US20030181514A1 (en) 2003-09-25
CA2411818A1 (en) 2002-01-10
AUPQ866500A0 (en) 2000-08-03
EP1303520B1 (en) 2007-09-26

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