DE60130641T2 - Pharmakologisch aktive antivirale peptide und methoden zu ihrer anwendung - Google Patents
Pharmakologisch aktive antivirale peptide und methoden zu ihrer anwendung Download PDFInfo
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- DE60130641T2 DE60130641T2 DE60130641T DE60130641T DE60130641T2 DE 60130641 T2 DE60130641 T2 DE 60130641T2 DE 60130641 T DE60130641 T DE 60130641T DE 60130641 T DE60130641 T DE 60130641T DE 60130641 T2 DE60130641 T2 DE 60130641T2
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- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002962 plaque-reduction assay Methods 0.000 description 1
- 108010048507 poliovirus receptor Proteins 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003834 purine nucleoside derivatives Chemical class 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 108010062760 transportan Proteins 0.000 description 1
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 description 1
- NBIIXXVUZAFLBC-HOSYLAQJSA-K trioxido(oxo)-$l^{5}-phosphane Chemical compound [O-][32P]([O-])([O-])=O NBIIXXVUZAFLBC-HOSYLAQJSA-K 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 239000012873 virucide Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18082300P | 2000-02-07 | 2000-02-07 | |
| US180823P | 2000-02-07 | ||
| US18405700P | 2000-02-22 | 2000-02-22 | |
| US184057P | 2000-02-22 | ||
| PCT/US2001/003813 WO2001057072A2 (en) | 2000-02-07 | 2001-02-06 | Pharmacologically active antiviral peptides and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60130641D1 DE60130641D1 (de) | 2007-11-08 |
| DE60130641T2 true DE60130641T2 (de) | 2008-06-26 |
Family
ID=26876670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60130641T Expired - Lifetime DE60130641T2 (de) | 2000-02-07 | 2001-02-06 | Pharmakologisch aktive antivirale peptide und methoden zu ihrer anwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7371809B2 (enExample) |
| EP (1) | EP1272510B1 (enExample) |
| JP (1) | JP4896333B2 (enExample) |
| AT (1) | ATE374208T1 (enExample) |
| AU (1) | AU784264B2 (enExample) |
| CA (1) | CA2399676C (enExample) |
| DE (1) | DE60130641T2 (enExample) |
| ES (1) | ES2293977T3 (enExample) |
| WO (1) | WO2001057072A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2293977T3 (es) | 2000-02-07 | 2008-04-01 | Wisconsin Alumni Research Foundation | Peptidos antivirales farmacologicamente activos y metodo para su uso. |
| AU2003210659A1 (en) * | 2002-01-24 | 2003-09-02 | Sangstat Medical Corporation | Combination therapy for treatment of hiv infection |
| US7432045B2 (en) | 2003-12-01 | 2008-10-07 | Wisconsin Alumni Research Foundation | Method of inhibiting influenza infection with antiviral peptides |
| JP4831410B2 (ja) | 2006-02-28 | 2011-12-07 | 東亞合成株式会社 | 抗ウイルス性ペプチドおよび抗ウイルス剤 |
| WO2009152518A1 (en) * | 2008-06-13 | 2009-12-17 | Wisconsin Alumni Research Foundation | Novel peptide adjuvant for influenza vaccination |
| JP2011524373A (ja) | 2008-06-13 | 2011-09-01 | ウィスコンシン・アルムナイ・リサーチ・ファウンデーション | インフルエンザウイルスに対する新規抗ウイルスペプチド |
| JP5996190B2 (ja) * | 2008-09-19 | 2016-09-21 | ヘンリー フォード ヘルス システムＨｅｎｒｙ Ｆｏｒｄ Ｈｅａｌｔｈ Ｓｙｓｔｅｍ | カルパイン阻害のための方法、系および組成物 |
| GB201012651D0 (en) * | 2010-07-28 | 2010-09-15 | Univ Edinburgh | Peptides |
| JP6022470B2 (ja) | 2010-11-24 | 2016-11-09 | タカラ バイオ ユーエスエー， インコーポレイテッド | 分散型タンパク質形質導入ドメインを含む誘導性発現系転写モジュレータおよびその使用方法 |
| US20120190107A1 (en) * | 2011-01-26 | 2012-07-26 | Dwayne Bisgrove | Enhanced protein transduction |
| ES2444299B1 (es) | 2012-08-23 | 2014-12-12 | Nutrición Técnica Deportiva, S.L. | Uso de un hidrolizado de caseina como agente antiherpético |
| JP7233737B2 (ja) * | 2017-05-26 | 2023-03-07 | ビラマティクス スンディリアン ブルハド | ペプチドおよび抗ウイルス剤としてのその使用 |
| IL311034A (en) * | 2021-08-23 | 2024-04-01 | Amytrx Therapeutics Inc | Molecules penetrate leukocytes specifically |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795740A (en) * | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4814432A (en) | 1987-05-22 | 1989-03-21 | Merck & Co., Inc. | Inhibitor of ribonucleotide reductase |
| US5260420A (en) | 1987-07-30 | 1993-11-09 | Centre Regional De Transfusion Sanguine De Lille | Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof |
| US5104854A (en) | 1989-02-01 | 1992-04-14 | Washington University | Antiviral peptides |
| CA1340682C (en) | 1989-07-07 | 1999-07-27 | Pierre Lavallee | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
| IT1231342B (it) | 1989-08-28 | 1991-11-28 | Prodotti Antibiotici Spa | Derivati peptidici farmacologicamente attivi e preparazioni farmaceutiche che li contengono |
| JPH0421635A (ja) * | 1990-05-16 | 1992-01-24 | Suntory Ltd | アセトアルデヒドの毒性抑制剤およびアセトアルデヒドの毒性抑制に有効な飲食物 |
| CA2033447C (en) | 1990-12-31 | 1999-08-31 | Robert Deziel | Synergistic combination for treating herpes infections |
| JPH05310784A (ja) | 1991-09-04 | 1993-11-22 | Merck & Co Inc | ヒト乳頭腫ウイルスタンパク質と網膜芽細胞腫遺伝子タンパク質との結合のペプチド阻害剤 |
| ATE273035T1 (de) | 1993-11-03 | 2004-08-15 | Clarion Pharmaceuticals Inc | Hämostatisches pflaster |
| US5441936A (en) | 1993-12-07 | 1995-08-15 | Houghten Pharmaceuticals, Inc. | Antiviral peptides |
| US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
| FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| AU3982497A (en) | 1996-07-30 | 1998-02-20 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Double-stranded rna dependent protein kinase derived peptides to promote proliferation of cells and tissues in controlled manner |
| US5877282A (en) * | 1996-09-20 | 1999-03-02 | Bristol-Myers Squibb Company | Peptide inhibitors of nuclear protein translocation having nuclear localization sequences and methods of use thereof |
| WO1998047913A2 (en) * | 1997-04-18 | 1998-10-29 | The University Of Medicine And Dentistry Of New Jersey | Inhibition of hiv-1 replication by a tat rna-binding domain peptide analog |
| AU741546B2 (en) | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| FR2766826B1 (fr) * | 1997-08-04 | 2001-05-18 | Pasteur Institut | Vecteurs derives d'anticorps pour le transfert de substances dans les cellules |
| EP1086126A1 (en) | 1998-06-10 | 2001-03-28 | The Queen's University of Belfast | Cell-permeable peptide |
| ES2293977T3 (es) | 2000-02-07 | 2008-04-01 | Wisconsin Alumni Research Foundation | Peptidos antivirales farmacologicamente activos y metodo para su uso. |
| US7432045B2 (en) | 2003-12-01 | 2008-10-07 | Wisconsin Alumni Research Foundation | Method of inhibiting influenza infection with antiviral peptides |
-
2001
- 2001-02-06 ES ES01908880T patent/ES2293977T3/es not_active Expired - Lifetime
- 2001-02-06 WO PCT/US2001/003813 patent/WO2001057072A2/en not_active Ceased
- 2001-02-06 DE DE60130641T patent/DE60130641T2/de not_active Expired - Lifetime
- 2001-02-06 AT AT01908880T patent/ATE374208T1/de not_active IP Right Cessation
- 2001-02-06 AU AU36700/01A patent/AU784264B2/en not_active Ceased
- 2001-02-06 US US09/777,560 patent/US7371809B2/en not_active Expired - Fee Related
- 2001-02-06 JP JP2001557903A patent/JP4896333B2/ja not_active Expired - Fee Related
- 2001-02-06 EP EP01908880A patent/EP1272510B1/en not_active Expired - Lifetime
- 2001-02-06 CA CA2399676A patent/CA2399676C/en not_active Expired - Fee Related
-
2008
- 2008-04-02 US US12/061,378 patent/US8748565B2/en not_active Expired - Fee Related
- 2008-11-07 US US12/291,325 patent/US8748566B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1272510B1 (en) | 2007-09-26 |
| ES2293977T3 (es) | 2008-04-01 |
| CA2399676C (en) | 2010-04-06 |
| US8748565B2 (en) | 2014-06-10 |
| AU784264B2 (en) | 2006-03-02 |
| US20090253624A1 (en) | 2009-10-08 |
| CA2399676A1 (en) | 2001-08-09 |
| JP2003522185A (ja) | 2003-07-22 |
| DE60130641D1 (de) | 2007-11-08 |
| WO2001057072A3 (en) | 2002-10-31 |
| WO2001057072A2 (en) | 2001-08-09 |
| US8748566B2 (en) | 2014-06-10 |
| AU3670001A (en) | 2001-08-14 |
| EP1272510A2 (en) | 2003-01-08 |
| US20120157376A1 (en) | 2012-06-21 |
| ATE374208T1 (de) | 2007-10-15 |
| US20050130884A1 (en) | 2005-06-16 |
| JP4896333B2 (ja) | 2012-03-14 |
| US7371809B2 (en) | 2008-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |