DE60130211D1 - Matrix-screening-verfahren - Google Patents
Matrix-screening-verfahrenInfo
- Publication number
- DE60130211D1 DE60130211D1 DE60130211T DE60130211T DE60130211D1 DE 60130211 D1 DE60130211 D1 DE 60130211D1 DE 60130211 T DE60130211 T DE 60130211T DE 60130211 T DE60130211 T DE 60130211T DE 60130211 D1 DE60130211 D1 DE 60130211D1
- Authority
- DE
- Germany
- Prior art keywords
- repertoires
- repertoire
- screening process
- combining
- members
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00277—Apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
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- B01J2219/00626—Covalent
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- B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
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- C07K—PEPTIDES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0015443A GB0015443D0 (en) | 2000-06-23 | 2000-06-23 | Matrix screening method |
GB0015443 | 2000-06-23 | ||
GB0026099A GB0026099D0 (en) | 2000-10-25 | 2000-10-25 | Matrix screening method |
GB0026099 | 2000-10-25 | ||
US24685100P | 2000-11-08 | 2000-11-08 | |
US246851P | 2000-11-08 | ||
PCT/GB2001/002831 WO2001098534A2 (en) | 2000-06-23 | 2001-06-22 | Matrix screening method |
Publications (2)
Publication Number | Publication Date |
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DE60130211D1 true DE60130211D1 (de) | 2007-10-11 |
DE60130211T2 DE60130211T2 (de) | 2008-05-29 |
Family
ID=27255773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60130211T Expired - Fee Related DE60130211T2 (de) | 2000-06-23 | 2001-06-22 | Matrix-screening-verfahren |
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EP (1) | EP1292710B1 (de) |
JP (1) | JP2004501379A (de) |
AT (1) | ATE371749T1 (de) |
AU (1) | AU2001266172A1 (de) |
CA (1) | CA2410857A1 (de) |
DE (1) | DE60130211T2 (de) |
DK (1) | DK1292710T3 (de) |
ES (1) | ES2292596T3 (de) |
PT (1) | PT1292710E (de) |
WO (1) | WO2001098534A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020115068A1 (en) * | 2000-06-23 | 2002-08-22 | Ian Tomlinson | Matrix screening method |
CA2434139C (en) | 2001-01-23 | 2014-05-27 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
WO2009075773A2 (en) | 2007-12-07 | 2009-06-18 | Goldstein Steven A | Identification of toxin ligands |
AU2010256880B2 (en) | 2009-06-02 | 2015-01-22 | Opko Health, Inc. | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
TW201124726A (en) | 2009-10-16 | 2011-07-16 | Univ Texas | Compositions and methods for producing coded peptoid libraries |
MX2015009340A (es) | 2013-01-24 | 2016-07-18 | Scripps Korea Antibody Inst | Biblioteca fv basada en la combinacion de proteinas y metodo de preparacion de la misma. |
US10988759B2 (en) | 2016-01-15 | 2021-04-27 | University Of Washington | High throughput protein-protein interaction screening in yeast liquid culture |
EP4150073A1 (de) | 2020-05-11 | 2023-03-22 | A-Alpha Bio, Inc. | Hochdurchsatz-screeningverfahren zur identifizierung kleiner zielmoleküle |
CN115768889A (zh) | 2020-06-01 | 2023-03-07 | A-阿尔法生物股份有限公司 | 表征和工程化蛋白质-蛋白质相互作用的方法 |
WO2024071112A1 (ja) * | 2022-09-27 | 2024-04-04 | 国立大学法人浜松医科大学 | 抗体の製造方法 |
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ATE241426T1 (de) * | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | Verfahren zur herstellung von polymerarrays |
WO1999028745A1 (en) * | 1997-11-27 | 1999-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification and characterization of interacting molecules by automated interaction mating |
AU6054900A (en) * | 1999-06-26 | 2001-01-31 | Odyssey Pharmaceuticals, Inc. | An in vivo library-versus-library selection of optimized protein-protein interactions |
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2001
- 2001-06-22 WO PCT/GB2001/002831 patent/WO2001098534A2/en active IP Right Grant
- 2001-06-22 ES ES01943634T patent/ES2292596T3/es not_active Expired - Lifetime
- 2001-06-22 DK DK01943634T patent/DK1292710T3/da active
- 2001-06-22 EP EP01943634A patent/EP1292710B1/de not_active Expired - Lifetime
- 2001-06-22 PT PT01943634T patent/PT1292710E/pt unknown
- 2001-06-22 AU AU2001266172A patent/AU2001266172A1/en not_active Abandoned
- 2001-06-22 CA CA002410857A patent/CA2410857A1/en not_active Abandoned
- 2001-06-22 DE DE60130211T patent/DE60130211T2/de not_active Expired - Fee Related
- 2001-06-22 JP JP2002504682A patent/JP2004501379A/ja not_active Withdrawn
- 2001-06-22 AT AT01943634T patent/ATE371749T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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EP1292710A2 (de) | 2003-03-19 |
WO2001098534A2 (en) | 2001-12-27 |
ES2292596T3 (es) | 2008-03-16 |
CA2410857A1 (en) | 2001-12-27 |
DE60130211T2 (de) | 2008-05-29 |
EP1292710B1 (de) | 2007-08-29 |
ATE371749T1 (de) | 2007-09-15 |
AU2001266172A1 (en) | 2002-01-02 |
JP2004501379A (ja) | 2004-01-15 |
DK1292710T3 (da) | 2007-12-27 |
PT1292710E (pt) | 2007-12-04 |
WO2001098534A3 (en) | 2002-05-30 |
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