ATE331038T1 - Verbessertes verfahren für reverses n-hybrid- screening - Google Patents

Verbessertes verfahren für reverses n-hybrid- screening

Info

Publication number
ATE331038T1
ATE331038T1 AT01918516T AT01918516T ATE331038T1 AT E331038 T1 ATE331038 T1 AT E331038T1 AT 01918516 T AT01918516 T AT 01918516T AT 01918516 T AT01918516 T AT 01918516T AT E331038 T1 ATE331038 T1 AT E331038T1
Authority
AT
Austria
Prior art keywords
inhibitors
antagonists
interactions
hybrid screening
reverse
Prior art date
Application number
AT01918516T
Other languages
English (en)
Inventor
Richard Hopkins
Ilya Serebriiskii
Paul Michael Watt
Erica Golemis
Original Assignee
Phylogica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPQ6131A external-priority patent/AUPQ613100A0/en
Priority claimed from AUPQ6437A external-priority patent/AUPQ643700A0/en
Priority claimed from AUPQ6830A external-priority patent/AUPQ683000A0/en
Priority claimed from AUPR1256A external-priority patent/AUPR125600A0/en
Application filed by Phylogica Ltd filed Critical Phylogica Ltd
Application granted granted Critical
Publication of ATE331038T1 publication Critical patent/ATE331038T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Special Wing (AREA)
  • Fuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01918516T 2000-03-08 2001-03-08 Verbessertes verfahren für reverses n-hybrid- screening ATE331038T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPQ6131A AUPQ613100A0 (en) 2000-03-08 2000-03-08 Improved reverse two hybrid screening method
AUPQ6437A AUPQ643700A0 (en) 2000-03-23 2000-03-23 Improved high-throughput reverse two hybrid screening method
AUPQ6830A AUPQ683000A0 (en) 2000-04-11 2000-04-11 Improved high-throughput reverse two-hybrid/reverse three- hybrid screening method
AUPR1256A AUPR125600A0 (en) 2000-11-06 2000-11-06 Dual fluorescent reporter construct for two hybrid and reverse two hybrid screening applications

Publications (1)

Publication Number Publication Date
ATE331038T1 true ATE331038T1 (de) 2006-07-15

Family

ID=27424505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01918516T ATE331038T1 (de) 2000-03-08 2001-03-08 Verbessertes verfahren für reverses n-hybrid- screening

Country Status (5)

Country Link
EP (1) EP1268842B1 (de)
AT (1) ATE331038T1 (de)
CA (1) CA2402111A1 (de)
DE (1) DE60120942T2 (de)
WO (1) WO2001066787A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211063A1 (de) * 2002-03-13 2003-10-09 Axaron Bioscience Ag Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo
AU2003900786A0 (en) * 2003-02-21 2003-03-13 Phylogica Limited Methods of regulating gene expression
US20080044815A1 (en) * 2003-05-30 2008-02-21 Paul Michael Watt Genetic Screen for Interaction Interface Mapping
CN1827763B (zh) * 2005-10-21 2010-04-14 中国人民解放军军事医学科学院基础医学研究所 筛选蛋白质解离肽的双启动子酵母随机肽库的构建方法
GB201420218D0 (en) * 2014-11-13 2014-12-31 Cambridge Entpr Ltd A method of screening for modulation of cell signalling pathways
MX2018014366A (es) 2016-05-27 2019-04-11 Synthex Inc Interfaces de proteina.
GB2584210B (en) 2017-11-22 2022-03-16 Synthex Inc Peptides for inhibiting RAD51

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399296B1 (en) * 1994-07-20 2002-06-04 The General Hospital Corporation Interaction trap systems for detecting protein interactions
NZ306767A (en) * 1995-04-11 2000-03-27 Univ Johns Hopkins Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems
CA2304367C (en) * 1997-09-16 2009-06-09 Fox Chase Cancer Center An improved yeast interaction trap assay
DE69935313T2 (de) * 1998-01-09 2007-11-15 Phylogica Ltd., Northbridge Nachweisverfahren für peptide

Also Published As

Publication number Publication date
EP1268842A1 (de) 2003-01-02
EP1268842B1 (de) 2006-06-21
CA2402111A1 (en) 2001-09-13
WO2001066787A1 (en) 2001-09-13
DE60120942T2 (de) 2007-02-01
DE60120942D1 (de) 2006-08-03
EP1268842A4 (de) 2003-09-17

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