ATE371749T1 - Matrix-screening-verfahren - Google Patents

Matrix-screening-verfahren

Info

Publication number
ATE371749T1
ATE371749T1 AT01943634T AT01943634T ATE371749T1 AT E371749 T1 ATE371749 T1 AT E371749T1 AT 01943634 T AT01943634 T AT 01943634T AT 01943634 T AT01943634 T AT 01943634T AT E371749 T1 ATE371749 T1 AT E371749T1
Authority
AT
Austria
Prior art keywords
repertoires
repertoire
screening method
combining
members
Prior art date
Application number
AT01943634T
Other languages
English (en)
Inventor
Lucy Jessica Holt
Ian Tomlinson
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0015443A external-priority patent/GB0015443D0/en
Priority claimed from GB0026099A external-priority patent/GB0026099D0/en
Application filed by Domantis Ltd filed Critical Domantis Ltd
Application granted granted Critical
Publication of ATE371749T1 publication Critical patent/ATE371749T1/de

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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/0241Drop counters; Drop formers
    • B01L3/0244Drop counters; Drop formers using pins
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    • B82NANOTECHNOLOGY
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    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1055Protein x Protein interaction, e.g. two hybrid selection
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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    • C12Q1/6813Hybridisation assays
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AT01943634T 2000-06-23 2001-06-22 Matrix-screening-verfahren ATE371749T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0015443A GB0015443D0 (en) 2000-06-23 2000-06-23 Matrix screening method
GB0026099A GB0026099D0 (en) 2000-10-25 2000-10-25 Matrix screening method
US24685100P 2000-11-08 2000-11-08

Publications (1)

Publication Number Publication Date
ATE371749T1 true ATE371749T1 (de) 2007-09-15

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AT01943634T ATE371749T1 (de) 2000-06-23 2001-06-22 Matrix-screening-verfahren

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US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
EP1360490B1 (de) 2001-01-23 2011-12-21 President and Fellows of Harvard College Nukleinsäure-programmierbare protein-arrays
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
US8716437B2 (en) 2007-12-07 2014-05-06 Steven A. Goldstein Identification of toxin ligands
CA2764153C (en) 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
BR112015017560A2 (pt) 2013-01-24 2018-05-15 Scripps Korea Antibody Institute biblioteca de fv à base de combinação de proteína e modo de preparação da mesma
US10988759B2 (en) 2016-01-15 2021-04-27 University Of Washington High throughput protein-protein interaction screening in yeast liquid culture
EP4150073A1 (de) 2020-05-11 2023-03-22 A-Alpha Bio, Inc. Hochdurchsatz-screeningverfahren zur identifizierung kleiner zielmoleküle
US20220251543A1 (en) 2020-06-01 2022-08-11 A-Alpha Bio, Inc. Methods for characterizing and engineering protein-protein interactions
WO2024071112A1 (ja) * 2022-09-27 2024-04-04 国立大学法人浜松医科大学 抗体の製造方法

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EP1588761A3 (de) * 1991-11-22 2005-11-23 Affymetrix, Inc. Verfahren zur Herstellung von Polymerarrays
GB2338711B (en) * 1997-11-27 2000-11-15 Max Planck Gesellschaft Identification and characterization of interacting molecules
EP1198586B1 (de) * 1999-06-26 2010-03-03 Odyssey Thera, Inc. Eine in vivo "bibliothek-gegen-bibliothek-selektion" von optimierten protein-protein-wechselwirkungen

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EP1292710B1 (de) 2007-08-29
AU2001266172A1 (en) 2002-01-02
EP1292710A2 (de) 2003-03-19
CA2410857A1 (en) 2001-12-27
WO2001098534A3 (en) 2002-05-30
WO2001098534A2 (en) 2001-12-27
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DE60130211D1 (de) 2007-10-11

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