DE602005021875D1 - Nachweisverfahren für einen liganden der selektiv eine funktionelle kaskade modulieren kann und ein target impliziert sowie dessen verwendung für hochdurchsatz-screening von molekülen die von interesse sind - Google Patents

Nachweisverfahren für einen liganden der selektiv eine funktionelle kaskade modulieren kann und ein target impliziert sowie dessen verwendung für hochdurchsatz-screening von molekülen die von interesse sind

Info

Publication number
DE602005021875D1
DE602005021875D1 DE602005021875T DE602005021875T DE602005021875D1 DE 602005021875 D1 DE602005021875 D1 DE 602005021875D1 DE 602005021875 T DE602005021875 T DE 602005021875T DE 602005021875 T DE602005021875 T DE 602005021875T DE 602005021875 D1 DE602005021875 D1 DE 602005021875D1
Authority
DE
Germany
Prior art keywords
screening
target
molecules
modulating
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021875T
Other languages
English (en)
Inventor
Pierre Martineau
Piona Dariavach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Montpellier I
Universite Montpellier 2 Sciences et Techniques
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Montpellier I
Universite Montpellier 2 Sciences et Techniques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Montpellier I, Universite Montpellier 2 Sciences et Techniques filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE602005021875D1 publication Critical patent/DE602005021875D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
DE602005021875T 2004-04-27 2005-04-25 Nachweisverfahren für einen liganden der selektiv eine funktionelle kaskade modulieren kann und ein target impliziert sowie dessen verwendung für hochdurchsatz-screening von molekülen die von interesse sind Active DE602005021875D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404433A FR2869416B1 (fr) 2004-04-27 2004-04-27 Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet.
PCT/FR2005/001020 WO2005106481A2 (fr) 2004-04-27 2005-04-25 Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible, et ses applications pour le criblage a haut-debit de molecules d'interet.

Publications (1)

Publication Number Publication Date
DE602005021875D1 true DE602005021875D1 (de) 2010-07-29

Family

ID=34945450

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021875T Active DE602005021875D1 (de) 2004-04-27 2005-04-25 Nachweisverfahren für einen liganden der selektiv eine funktionelle kaskade modulieren kann und ein target impliziert sowie dessen verwendung für hochdurchsatz-screening von molekülen die von interesse sind

Country Status (9)

Country Link
US (1) US9110077B2 (de)
EP (1) EP1743178B1 (de)
JP (1) JP4814220B2 (de)
AT (1) ATE471518T1 (de)
CA (1) CA2564767C (de)
DE (1) DE602005021875D1 (de)
ES (1) ES2348478T3 (de)
FR (1) FR2869416B1 (de)
WO (1) WO2005106481A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090309617A1 (en) * 2007-08-24 2009-12-17 Ye Fang Biosensor antibody functional mapping
FR2929851B1 (fr) 2008-04-09 2012-11-30 Centre Nat Rech Scient Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
EP2752487A1 (de) 2013-01-03 2014-07-09 Sanofi Intrazelluläres Phänotypen-Screening

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858657A (en) * 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
WO1994015638A1 (en) * 1992-12-31 1994-07-21 Ramot University Authority For Applied Research And Industrial Development Ltd. Antibodies directed against binding-associated epitopes
WO1994025565A1 (en) * 1993-04-23 1994-11-10 Ariad Pharmaceuticals, Inc. HUMAN $i(SYK)
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
JP2002515744A (ja) * 1996-05-20 2002-05-28 シグナル ファーマシュウティカルズ，インコーポレイテッド マイトジェン活性化プロテインキナーゼｐ３８―２およびその使用方法
GB9726851D0 (en) * 1997-12-19 1998-02-18 Zeneca Ltd Human signal transduction serine/threonine kinase
GB2344886B (en) * 1999-03-10 2000-11-01 Medical Res Council Selection of intracellular immunoglobulins
EP1180244A2 (de) * 1999-05-13 2002-02-20 Caliper Technologies Corporation High througput screening verfahren und vorrichtungen
AU6058500A (en) 1999-06-30 2001-01-31 Center For Blood Research, The Fusion protein and uses thereof
US6709839B1 (en) * 1999-09-24 2004-03-23 Rigel Pharmaceuticals, Inc. SYK-UBP proteins, compositions and methods of use
JP2003009899A (ja) * 2001-05-28 2003-01-14 New Industry Research Organization 化合物のスクリーニング方法
WO2003059943A2 (en) * 2002-01-18 2003-07-24 Karo Bio Ab Conformation-specific, protein kinase binding peptides and related methods and products
US7244592B2 (en) * 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
WO2004020619A1 (en) * 2002-08-30 2004-03-11 Ingenium Pharmaceuticals Ag Modified phospholipase c-gamma-2, expression products, and non-human animal models comprising said genes, and therapeutic uses
ITRM20020588A1 (it) * 2002-11-21 2004-05-22 Lay Line Genomics Spa Metodo per isolare anticorpi intracellulari neutralizzanti di interazioni proteiche.

Also Published As

Publication number Publication date
CA2564767A1 (fr) 2005-11-10
FR2869416B1 (fr) 2007-01-12
JP4814220B2 (ja) 2011-11-16
US9110077B2 (en) 2015-08-18
ES2348478T3 (es) 2010-12-07
EP1743178B1 (de) 2010-06-16
WO2005106481A2 (fr) 2005-11-10
WO2005106481A3 (fr) 2006-11-02
FR2869416A1 (fr) 2005-10-28
EP1743178A2 (de) 2007-01-17
ATE471518T1 (de) 2010-07-15
JP2007534954A (ja) 2007-11-29
US20080146453A1 (en) 2008-06-19
CA2564767C (fr) 2014-06-17

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