DE60127561D1 - Phagen-abhängige superproduktion biologisch aktiver proteine und peptide - Google Patents
Phagen-abhängige superproduktion biologisch aktiver proteine und peptideInfo
- Publication number
- DE60127561D1 DE60127561D1 DE60127561T DE60127561T DE60127561D1 DE 60127561 D1 DE60127561 D1 DE 60127561D1 DE 60127561 T DE60127561 T DE 60127561T DE 60127561 T DE60127561 T DE 60127561T DE 60127561 D1 DE60127561 D1 DE 60127561D1
- Authority
- DE
- Germany
- Prior art keywords
- biologically active
- active proteins
- peptides
- cells
- producer strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000701959 Escherichia virus Lambda Species 0.000 abstract 1
- 101710137500 T7 RNA polymerase Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000002101 lytic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22543700P | 2000-08-15 | 2000-08-15 | |
| US225437P | 2000-08-15 | ||
| PCT/US2001/025477 WO2002014468A2 (en) | 2000-08-15 | 2001-08-15 | Phage-dependent superproduction of biologically active protein and peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60127561D1 true DE60127561D1 (de) | 2007-05-10 |
| DE60127561T2 DE60127561T2 (de) | 2007-12-13 |
Family
ID=22844863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60127561T Expired - Lifetime DE60127561T2 (de) | 2000-08-15 | 2001-08-15 | Phagen-abhängige superproduktion biologisch aktiver proteine und peptide |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6773899B2 (de) |
| EP (1) | EP1309604B1 (de) |
| JP (1) | JP2004528005A (de) |
| KR (1) | KR100761486B1 (de) |
| AT (1) | ATE358135T1 (de) |
| AU (2) | AU8491401A (de) |
| CA (1) | CA2419203A1 (de) |
| DE (1) | DE60127561T2 (de) |
| ES (1) | ES2284677T3 (de) |
| WO (1) | WO2002014468A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7252818B2 (en) * | 1998-07-24 | 2007-08-07 | Cardiovascular Biotherapeutics, Inc. | Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis |
| US6268178B1 (en) * | 1999-05-25 | 2001-07-31 | Phage Biotechnology Corp. | Phage-dependent super-production of biologically active protein and peptides |
| US20050129711A1 (en) * | 2002-11-14 | 2005-06-16 | Janakiraman Ramachandran | Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression |
| US20090311742A1 (en) * | 2005-02-22 | 2009-12-17 | David Tabaczynski | Phage-Derived Vectors and Methods for Protein Expression |
| EP2356142B1 (de) * | 2008-11-10 | 2016-08-10 | Novo Nordisk A/S | E. coli bl21 stamm ohne funktionelles gruppe ii gencluster für kapselproteine |
| TWI434698B (zh) * | 2009-08-14 | 2014-04-21 | Eu Sol Biotech Co Ltd | 人類酸性纖維母細胞生長因子之醫藥用途 |
| WO2011053998A2 (en) * | 2009-11-02 | 2011-05-05 | The Salk Institute For Biological Studies | Targeting of modifying enzymes for protein evolution |
| JP6174019B2 (ja) * | 2011-07-07 | 2017-08-02 | デルフィ ジェネティクス | 遺伝子組換えファージ及びその利用 |
| US9920323B2 (en) | 2011-07-07 | 2018-03-20 | Delphi Genetics | Genetically modified phage and use thereof |
| EP2543720A1 (de) * | 2011-07-07 | 2013-01-09 | Delphi Genetics | Genetisch modifizierte Phagen und Verwendung dafür |
| WO2015195845A1 (en) * | 2014-06-17 | 2015-12-23 | Xycrobe Therapeutics, Inc. | Genetically modified bacteria and methods for genetic modification of bacteria |
| DE102014212675A1 (de) * | 2014-07-01 | 2016-01-07 | Wacker Chemie Ag | T7-Expressionssystem, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung von rekombinanten Proteinen |
| WO2017147507A1 (en) | 2016-02-24 | 2017-08-31 | Xycrobe Therapeutics, Inc. | Skin probiotic formulation |
| WO2019068006A1 (en) * | 2017-09-29 | 2019-04-04 | The Charles Stark Draper Laboratory, Inc. | CELLULAR LYSE CONTROLLED BY STIMULUS |
| CN110172451A (zh) * | 2019-05-05 | 2019-08-27 | 昆明理工大学 | 一种高通量分离噬菌体的方法 |
| EP4167937A4 (de) | 2020-06-23 | 2024-11-13 | Crown Laboratories Inc | Probiotische hautformulierungen |
| CN113881641B (zh) * | 2021-10-19 | 2023-06-23 | 广西大学 | 一株大肠杆菌噬菌体ep01及其应用 |
| CN118546850A (zh) * | 2022-09-29 | 2024-08-27 | 浙江大学杭州国际科创中心 | 高产重组蛋白的需钠弧菌工程菌及其应用 |
| CN116143886A (zh) * | 2022-10-12 | 2023-05-23 | 中国海洋大学 | 铜绿假单胞菌噬菌体编码的Gp21蛋白及其在抑制大肠杆菌噬菌体感染方面的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1089119A1 (ru) * | 1982-11-29 | 1984-04-30 | Институт Молекулярной Биологии И Генетики Ан Усср | Способ получени @ -лактамазы |
| GB2143238A (en) * | 1983-03-31 | 1985-02-06 | Dr Anthony Stuart Breeze | A method for enzyme liberation from bacterial cells |
| US4637980A (en) * | 1983-08-09 | 1987-01-20 | Smithkline Beckman Corporation | Externalization of products of bacteria |
| JP2803184B2 (ja) * | 1988-07-04 | 1998-09-24 | 武田薬品工業株式会社 | 酸性線維芽細胞成長因子の抗体，その用途およびペプチド |
| GB2223496B (en) * | 1988-08-08 | 1992-05-27 | British Bio Technology | Synthetic gene encoding mature human acid fibroblast growth factor |
| US5175147A (en) * | 1988-08-19 | 1992-12-29 | Takeda Chemical Industries, Ltd | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract |
| JPH0343088A (ja) * | 1989-09-29 | 1991-02-25 | Takeda Chem Ind Ltd | ａＦＧＦ蛋白質の製造法 |
| US6268178B1 (en) * | 1999-05-25 | 2001-07-31 | Phage Biotechnology Corp. | Phage-dependent super-production of biologically active protein and peptides |
-
2001
- 2001-08-15 WO PCT/US2001/025477 patent/WO2002014468A2/en active IP Right Grant
- 2001-08-15 AT AT01964014T patent/ATE358135T1/de active
- 2001-08-15 EP EP01964014A patent/EP1309604B1/de not_active Expired - Lifetime
- 2001-08-15 DE DE60127561T patent/DE60127561T2/de not_active Expired - Lifetime
- 2001-08-15 JP JP2002519596A patent/JP2004528005A/ja active Pending
- 2001-08-15 ES ES01964014T patent/ES2284677T3/es not_active Expired - Lifetime
- 2001-08-15 AU AU8491401A patent/AU8491401A/xx active Pending
- 2001-08-15 US US09/929,918 patent/US6773899B2/en not_active Expired - Fee Related
- 2001-08-15 KR KR1020037002240A patent/KR100761486B1/ko not_active IP Right Cessation
- 2001-08-15 CA CA002419203A patent/CA2419203A1/en not_active Abandoned
- 2001-08-15 AU AU2001284914A patent/AU2001284914B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002014468A3 (en) | 2002-05-10 |
| EP1309604B1 (de) | 2007-03-28 |
| KR20030031979A (ko) | 2003-04-23 |
| US6773899B2 (en) | 2004-08-10 |
| EP1309604A2 (de) | 2003-05-14 |
| KR100761486B1 (ko) | 2007-10-04 |
| ES2284677T3 (es) | 2007-11-16 |
| CA2419203A1 (en) | 2002-02-21 |
| AU2001284914B2 (en) | 2006-02-09 |
| EP1309604A4 (de) | 2006-10-11 |
| AU8491401A (en) | 2002-02-25 |
| DE60127561T2 (de) | 2007-12-13 |
| WO2002014468A2 (en) | 2002-02-21 |
| JP2004528005A (ja) | 2004-09-16 |
| US20020090678A1 (en) | 2002-07-11 |
| ATE358135T1 (de) | 2007-04-15 |
| WO2002014468A9 (en) | 2003-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PHAGE BIOTECHNOLOGY CORP., LAS VEGAS, NEV., US Owner name: CARDIOVASCULAR BIO THERAPEUTICS,INC., LAS VEGA, US |
|
| 8364 | No opposition during term of opposition |