DE60126148D1 - Verfahren zur herstellung von heterologen proteinen in fungi - Google Patents

Verfahren zur herstellung von heterologen proteinen in fungi

Info

Publication number
DE60126148D1
DE60126148D1 DE60126148T DE60126148T DE60126148D1 DE 60126148 D1 DE60126148 D1 DE 60126148D1 DE 60126148 T DE60126148 T DE 60126148T DE 60126148 T DE60126148 T DE 60126148T DE 60126148 D1 DE60126148 D1 DE 60126148D1
Authority
DE
Germany
Prior art keywords
heterologic
fungi
proteins
preparation
inducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60126148T
Other languages
English (en)
Other versions
DE60126148T2 (de
Inventor
De Laar Antonius M J Van
Nigel M Lindner
Peter Nieuwpoort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever NV
Original Assignee
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV filed Critical Unilever NV
Publication of DE60126148D1 publication Critical patent/DE60126148D1/de
Application granted granted Critical
Publication of DE60126148T2 publication Critical patent/DE60126148T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60126148T 2000-12-13 2001-11-16 Verfahren zur herstellung von heterologen proteinen in fungi Expired - Lifetime DE60126148T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00311095 2000-12-13
EP00311095 2000-12-13
PCT/EP2001/013457 WO2002048382A2 (en) 2000-12-13 2001-11-16 Method for the production of a heterologous protein by a fungus

Publications (2)

Publication Number Publication Date
DE60126148D1 true DE60126148D1 (de) 2007-03-08
DE60126148T2 DE60126148T2 (de) 2007-05-31

Family

ID=8173440

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60126148T Expired - Lifetime DE60126148T2 (de) 2000-12-13 2001-11-16 Verfahren zur herstellung von heterologen proteinen in fungi

Country Status (18)

Country Link
US (1) US7560249B2 (de)
EP (1) EP1349945B1 (de)
JP (1) JP4494716B2 (de)
CN (1) CN1481439A (de)
AT (1) ATE351911T1 (de)
AU (2) AU1604902A (de)
BR (1) BR0116675A (de)
CA (1) CA2427665C (de)
CZ (1) CZ303983B6 (de)
DE (1) DE60126148T2 (de)
ES (1) ES2278681T3 (de)
HU (1) HU228689B1 (de)
IL (1) IL156438A0 (de)
MX (1) MXPA03005358A (de)
PL (1) PL204737B1 (de)
SK (1) SK287621B6 (de)
WO (1) WO2002048382A2 (de)
ZA (1) ZA200303353B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121916A1 (de) * 2006-12-20 2009-11-25 Danisco US, INC., Genencor Division Tests für verbesserte pilzstämme
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
HUE060418T2 (hu) * 2011-05-20 2023-02-28 H Lundbeck As Eljárás nagy tisztaságú multi-alegység proteinek, például antitestek elõállítására transzformált mikroorganizmusokban, például Pichia pastorisban
AU2016273912B2 (en) * 2011-05-20 2018-08-02 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US10150968B2 (en) 2011-08-19 2018-12-11 Alderbio Holdings Llc Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
WO2014152100A1 (en) 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Methods of producing antibodies in yeast
US20160230141A1 (en) * 2013-09-19 2016-08-11 Research Foundation Of The City University Of New York Process for increased yeast biomass
DK4089113T3 (da) 2015-03-31 2024-02-05 Sorriso Pharmaceuticals Inc Polypeptider
KR20170132154A (ko) 2015-03-31 2017-12-01 브이에이치스퀘어드 리미티드 프로테아제-절단가능 링커를 갖는 펩티드 구조물
WO2016156474A1 (en) 2015-03-31 2016-10-06 Vhsquared Limited Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a
EP3277706A1 (de) 2015-03-31 2018-02-07 VHsquared Limited Polypeptid mit immunglobulinkettenvariabler domäne mit bindung an clostridium-difficile-toxin b
EP3519438A1 (de) 2016-09-30 2019-08-07 VHsquared Limited Zusammensetzungen
MX2021015761A (es) 2019-06-21 2022-04-18 Sorriso Pharmaceuticals Inc Polipeptidos.
KR20220063148A (ko) 2019-06-21 2022-05-17 소리소 파마슈티컬스 인크. 조성물
CN114514243A (zh) 2019-06-21 2022-05-17 索瑞索制药公司 多肽

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0778348T3 (da) 1989-07-07 2000-12-04 Unilever Nv Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en ekspr
JP3926843B2 (ja) 1995-07-05 2007-06-06 ユニリーバー・ナームローゼ・ベンノートシヤープ 食品級生物における海洋魚不凍ペプチドの発現及び食品におけるその適用
ATE428733T1 (de) 2000-03-14 2009-05-15 Unilever Nv Variabele domänen der schweren kette eines antikörpers gegen menschliche ernährungslipasen und deren verwendungen

Also Published As

Publication number Publication date
WO2002048382A2 (en) 2002-06-20
EP1349945B1 (de) 2007-01-17
HUP0302655A3 (en) 2004-10-28
MXPA03005358A (es) 2003-10-06
ATE351911T1 (de) 2007-02-15
JP2004515249A (ja) 2004-05-27
CA2427665A1 (en) 2002-06-20
CZ303983B6 (cs) 2013-07-31
SK287621B6 (sk) 2011-04-05
BR0116675A (pt) 2003-11-04
US7560249B2 (en) 2009-07-14
US20040077069A1 (en) 2004-04-22
AU2002216049B2 (en) 2005-11-24
JP4494716B2 (ja) 2010-06-30
IL156438A0 (en) 2004-01-04
DE60126148T2 (de) 2007-05-31
PL204737B1 (pl) 2010-02-26
ZA200303353B (en) 2004-04-30
HUP0302655A2 (hu) 2003-11-28
HU228689B1 (hu) 2013-05-28
PL362773A1 (en) 2004-11-02
CA2427665C (en) 2011-10-11
AU1604902A (en) 2002-06-24
EP1349945A2 (de) 2003-10-08
ES2278681T3 (es) 2007-08-16
WO2002048382A3 (en) 2003-01-30
SK7402003A3 (en) 2003-09-11
CN1481439A (zh) 2004-03-10
CZ20031659A3 (cs) 2003-11-12

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