DE60113689T2 - 2-aminothiazolinderivate und ihre verwendung als no-synthase inhibitoren - Google Patents

2-aminothiazolinderivate und ihre verwendung als no-synthase inhibitoren Download PDF

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Publication number
DE60113689T2
DE60113689T2 DE60113689T DE60113689T DE60113689T2 DE 60113689 T2 DE60113689 T2 DE 60113689T2 DE 60113689 T DE60113689 T DE 60113689T DE 60113689 T DE60113689 T DE 60113689T DE 60113689 T2 DE60113689 T2 DE 60113689T2
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DE
Germany
Prior art keywords
amine
dihydro
thiazol
temperature
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113689T
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German (de)
English (en)
Other versions
DE60113689D1 (de
Inventor
Jean-Christophe Carry
Dominique Damour
Claude Guyon
Serge Mignani
Antony Bigot
Eric Bacque
Michel Tabart
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Aventis Pharma SA
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Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of DE60113689D1 publication Critical patent/DE60113689D1/de
Application granted granted Critical
Publication of DE60113689T2 publication Critical patent/DE60113689T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60113689T 2000-06-09 2001-06-07 2-aminothiazolinderivate und ihre verwendung als no-synthase inhibitoren Expired - Lifetime DE60113689T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0007397A FR2810037B1 (fr) 2000-06-09 2000-06-09 Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible
FR0007397 2000-06-09
PCT/FR2001/001760 WO2001094325A1 (fr) 2000-06-09 2001-06-07 Derives de 2-aminothiazoline et leur utilisation comme inhibiteurs de no-synthase

Publications (2)

Publication Number Publication Date
DE60113689D1 DE60113689D1 (de) 2006-02-09
DE60113689T2 true DE60113689T2 (de) 2006-07-13

Family

ID=8851134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60113689T Expired - Lifetime DE60113689T2 (de) 2000-06-09 2001-06-07 2-aminothiazolinderivate und ihre verwendung als no-synthase inhibitoren

Country Status (29)

Country Link
EP (1) EP1299365B1 (da)
JP (1) JP4238026B2 (da)
KR (1) KR20030025931A (da)
CN (1) CN1202096C (da)
AP (1) AP2002002708A0 (da)
AR (1) AR029937A1 (da)
AT (1) ATE305460T1 (da)
AU (1) AU2001266124A1 (da)
BR (1) BR0111986A (da)
CA (1) CA2411760C (da)
DE (1) DE60113689T2 (da)
DK (1) DK1299365T3 (da)
DZ (1) DZ3367A1 (da)
EA (1) EA200300010A1 (da)
EC (1) ECSP024375A (da)
ES (1) ES2248347T3 (da)
FR (1) FR2810037B1 (da)
HK (1) HK1057900A1 (da)
HR (1) HRP20020970A2 (da)
HU (1) HUP0301000A2 (da)
IL (1) IL153328A0 (da)
MA (1) MA25814A1 (da)
MX (1) MXPA02012071A (da)
NO (1) NO20025884L (da)
NZ (1) NZ522968A (da)
OA (1) OA12286A (da)
PL (1) PL360285A1 (da)
WO (1) WO2001094325A1 (da)
ZA (1) ZA200209769B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003040115A1 (fr) * 2001-11-09 2003-05-15 Aventis Pharma S.A. Derives de 2-amino-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
DE60140964D1 (en) * 2001-09-26 2010-02-11 Yissum Res Dev Co Sphingolipiden
DK1446402T3 (da) * 2001-11-09 2006-03-06 Aventis Pharma Sa 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase
IL161843A0 (en) * 2001-11-09 2005-11-20 Aventis Pharma Sa Use of 2-amino-4-pyridylmethyl-thiazoline dervatives as inhibitors of inducible no-synthase
AU2002238889A1 (en) * 2002-03-14 2003-09-22 Dainippon Pharmaceutical Co., Ltd. Nitrogen monoxide synthase inhibitors
ATE375333T1 (de) 2002-08-07 2007-10-15 Neuraxon Inc Aminobenzothiazolverbindungen mit nos-hemmender wirkung
DE10332560B4 (de) * 2003-07-11 2010-07-08 Chiracon Gmbh Verfahren zur Herstellung von ß- Heteroaryl-2-alanin-Verbindungen über 2-Amino-2-(heteroarylmethyl)-carbonsäure-Verbindungen
KR101800507B1 (ko) 2015-09-18 2018-01-18 주식회사 이엔이티아이 자동세척 스크린과 식물정화장치를 활용하여 지속적으로 유입되는 생활하수나 공정폐수가 유입되는 오염하천정화를 위한 방법 및 그 장치

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066662A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors
JPH08503940A (ja) * 1992-11-27 1996-04-30 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬
ATE177078T1 (de) * 1993-10-21 1999-03-15 Searle & Co Amidino-derivate als no-synthetase inhibitoren
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
ES2238335T3 (es) * 1999-12-24 2005-09-01 Kyowa Hakko Kogyo Co., Ltd. Derivados de purina condensados.

Also Published As

Publication number Publication date
WO2001094325A1 (fr) 2001-12-13
DE60113689D1 (de) 2006-02-09
EP1299365A1 (fr) 2003-04-09
NZ522968A (en) 2005-07-29
JP2003535853A (ja) 2003-12-02
ES2248347T3 (es) 2006-03-16
EA200300010A1 (ru) 2003-06-26
IL153328A0 (en) 2003-07-06
CA2411760C (fr) 2009-12-29
DZ3367A1 (fr) 2001-12-13
JP4238026B2 (ja) 2009-03-11
BR0111986A (pt) 2003-04-01
NO20025884D0 (no) 2002-12-06
NO20025884L (no) 2003-01-29
KR20030025931A (ko) 2003-03-29
ZA200209769B (en) 2004-03-02
OA12286A (en) 2006-05-12
ATE305460T1 (de) 2005-10-15
AR029937A1 (es) 2003-07-23
AU2001266124A1 (en) 2001-12-17
MXPA02012071A (es) 2004-09-10
CN1444572A (zh) 2003-09-24
DK1299365T3 (da) 2006-02-06
CA2411760A1 (fr) 2001-12-13
FR2810037B1 (fr) 2004-04-23
HUP0301000A2 (hu) 2003-08-28
PL360285A1 (en) 2004-09-06
MA25814A1 (fr) 2003-07-01
HK1057900A1 (en) 2004-04-23
CN1202096C (zh) 2005-05-18
HRP20020970A2 (en) 2005-02-28
EP1299365B1 (fr) 2005-09-28
AP2002002708A0 (en) 2002-12-31
ECSP024375A (es) 2003-02-06
FR2810037A1 (fr) 2001-12-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC