DE60112073D1 - Impfstoffzusammensetzung und verfahren zur herstellung derselben sowie verfahren zur impfung von wirbeltieren - Google Patents

Impfstoffzusammensetzung und verfahren zur herstellung derselben sowie verfahren zur impfung von wirbeltieren

Info

Publication number
DE60112073D1
DE60112073D1 DE60112073T DE60112073T DE60112073D1 DE 60112073 D1 DE60112073 D1 DE 60112073D1 DE 60112073 T DE60112073 T DE 60112073T DE 60112073 T DE60112073 T DE 60112073T DE 60112073 D1 DE60112073 D1 DE 60112073D1
Authority
DE
Germany
Prior art keywords
antigen
vaccine composition
alginate
improved
microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60112073T
Other languages
English (en)
Other versions
DE60112073T2 (de
Inventor
Terry L Bowersock
Paul Guimond
Tzu-Chi R Ju
Argaw Kidane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60112073D1 publication Critical patent/DE60112073D1/de
Publication of DE60112073T2 publication Critical patent/DE60112073T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE60112073T 2000-05-12 2001-05-11 Impfstoffzusammensetzung und verfahren zur herstellung derselben sowie verfahren zur impfung von wirbeltieren Expired - Fee Related DE60112073T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20386400P 2000-05-12 2000-05-12
US203864P 2000-05-12
PCT/US2001/015235 WO2001087270A2 (en) 2000-05-12 2001-05-11 Vaccine composition, method of preparing the same, and method of vaccinating vertebrates

Publications (2)

Publication Number Publication Date
DE60112073D1 true DE60112073D1 (de) 2005-08-25
DE60112073T2 DE60112073T2 (de) 2006-04-20

Family

ID=22755628

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112073T Expired - Fee Related DE60112073T2 (de) 2000-05-12 2001-05-11 Impfstoffzusammensetzung und verfahren zur herstellung derselben sowie verfahren zur impfung von wirbeltieren

Country Status (10)

Country Link
US (2) US6656470B2 (de)
EP (1) EP1280521B1 (de)
AT (1) ATE299696T1 (de)
AU (1) AU2001261433A1 (de)
DE (1) DE60112073T2 (de)
DK (1) DK1280521T3 (de)
ES (1) ES2243497T3 (de)
HK (1) HK1049800A1 (de)
PT (1) PT1280521E (de)
WO (1) WO2001087270A2 (de)

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US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
US6693086B1 (en) * 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
ES2243497T3 (es) * 2000-05-12 2005-12-01 PHARMACIA & UPJOHN COMPANY LLC Composicion de vacuna, procedimiento de preparacion de la misma y procedimiento para vacunacion de vertebrados.
AU2002233557A1 (en) * 2001-03-05 2002-09-19 Forinnova As Immune response potentiation
FR2823119B1 (fr) * 2001-04-05 2004-02-20 Seppic Sa Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant
US7119172B2 (en) * 2001-05-21 2006-10-10 The Brigham And Women's Hospital, Inc. P. aeruginosa mucoid exopolysaccharide specific binding peptides
WO2002094854A2 (en) * 2001-05-21 2002-11-28 The Brigham And Women's Hospital, Inc. P.aeruginosa mucoid exopolysaccharide specific binding peptides
US6678583B2 (en) * 2001-08-06 2004-01-13 Seminet, Inc. Robotic storage buffer system for substrate carrier pods
US7039499B1 (en) * 2002-08-02 2006-05-02 Seminet Inc. Robotic storage buffer system for substrate carrier pods
KR100548925B1 (ko) * 2002-10-23 2006-02-02 한미약품 주식회사 약물의 경구투여용 서방성 조성물
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
CA2521050A1 (en) * 2003-04-02 2004-10-14 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations and related methods of use
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
US7081227B2 (en) * 2004-06-07 2006-07-25 The Reagents Of The University Of California Amphiphilic mediated sample preparation for micro-flow cytometry
WO2006034395A2 (en) * 2004-09-21 2006-03-30 The Brigham And Women's Hospital, Inc. Methods and compositions relating to mannuronic acid specific binding peptides
EP2444071A1 (de) * 2004-09-27 2012-04-25 Sigmoid Pharma Limited Minikapsel-Formulierungen
WO2006059846A1 (en) * 2004-12-01 2006-06-08 Lg Life Sciences, Ltd. Formulation of sec1 mutated protein and method for formulation of the same
US20060177468A1 (en) * 2005-01-05 2006-08-10 Philadelphia Health and Education Corporation (d/b/a Drexel University College of Medicine Delivery vehicles, bioactive substances and viral vaccines
WO2007084500A2 (en) * 2006-01-13 2007-07-26 Advanced Bionutrition Corporation Continuous spray-capture production system
CN103120653B (zh) * 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
EP2061587A1 (de) 2007-04-26 2009-05-27 Sigmoid Pharma Limited Herstellung mehrerer minikapseln
JP2010526053A (ja) * 2007-05-01 2010-07-29 シグモイド・ファーマ・リミテッド ニモジピン医薬組成物
US8709827B2 (en) * 2007-06-28 2014-04-29 Surmodics, Inc. Polypeptide microparticles
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US20140356396A1 (en) * 2011-08-25 2014-12-04 Brian L. Pulliam Rotavirus preparations with excess calcium ions and high viscosities that ensure viability at elevated temperatures
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
CA2932681C (en) * 2013-12-06 2022-08-30 Moti Harel Composition for oral delivery of bioactive agents
JP6716582B2 (ja) 2014-11-07 2020-07-01 サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ シクロスポリンを含む組成物
WO2017097844A1 (en) * 2015-12-07 2017-06-15 Schlumberger Norge As Microsphere compositions and methods for production in oil-based drilling fluids
GB202205231D0 (en) * 2022-04-09 2022-05-25 Nasaleze Patents Ltd Vaccine compositions

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ES2243497T3 (es) * 2000-05-12 2005-12-01 PHARMACIA & UPJOHN COMPANY LLC Composicion de vacuna, procedimiento de preparacion de la misma y procedimiento para vacunacion de vertebrados.

Also Published As

Publication number Publication date
DE60112073T2 (de) 2006-04-20
US6656470B2 (en) 2003-12-02
EP1280521A2 (de) 2003-02-05
AU2001261433A1 (en) 2001-11-26
PT1280521E (pt) 2005-10-31
WO2001087270A2 (en) 2001-11-22
ATE299696T1 (de) 2005-08-15
WO2001087270B1 (en) 2002-08-15
US20020009457A1 (en) 2002-01-24
US7160544B2 (en) 2007-01-09
ES2243497T3 (es) 2005-12-01
EP1280521B1 (de) 2005-07-20
HK1049800A1 (en) 2003-05-30
WO2001087270A3 (en) 2002-05-16
DK1280521T3 (da) 2005-08-08
US20040071727A1 (en) 2004-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee