DE60101939D1 - Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffe - Google Patents
Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffeInfo
- Publication number
- DE60101939D1 DE60101939D1 DE60101939T DE60101939T DE60101939D1 DE 60101939 D1 DE60101939 D1 DE 60101939D1 DE 60101939 T DE60101939 T DE 60101939T DE 60101939 T DE60101939 T DE 60101939T DE 60101939 D1 DE60101939 D1 DE 60101939D1
- Authority
- DE
- Germany
- Prior art keywords
- fluorescine
- inks
- nitrogen heterocycles
- substituted
- default
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US498702 | 2000-02-07 | ||
US09/498,702 US6221604B1 (en) | 2000-02-07 | 2000-02-07 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
PCT/US2001/003772 WO2001057264A2 (en) | 2000-02-07 | 2001-02-05 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60101939D1 true DE60101939D1 (de) | 2004-03-11 |
DE60101939T2 DE60101939T2 (de) | 2005-01-05 |
Family
ID=23982139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60101939T Expired - Lifetime DE60101939T2 (de) | 2000-02-07 | 2001-02-05 | Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffe |
Country Status (9)
Country | Link |
---|---|
US (2) | US6221604B1 (de) |
EP (1) | EP1196640B1 (de) |
JP (5) | JP2003521571A (de) |
AT (1) | ATE258992T1 (de) |
AU (1) | AU772739B2 (de) |
CA (1) | CA2368495C (de) |
DE (1) | DE60101939T2 (de) |
ES (1) | ES2211768T3 (de) |
WO (1) | WO2001057264A2 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221604B1 (en) * | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
EP1317464B1 (de) * | 2000-10-11 | 2009-05-13 | Applera Corporation | Fluoreszierende nukleobasekonjugate mit anionische linker |
US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
US8569516B2 (en) * | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
WO2003040395A2 (en) * | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
US20030148284A1 (en) * | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
US7026166B2 (en) * | 2002-01-22 | 2006-04-11 | Chiron Corporation | Fluorogenic dyes |
US7074597B2 (en) * | 2002-07-12 | 2006-07-11 | The Trustees Of Columbia University In The City Of New York | Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry |
US7704756B2 (en) * | 2003-01-21 | 2010-04-27 | Novartis Vaccines And Diagnostics, Inc. | Fluorogenic dyes |
KR20070121853A (ko) | 2003-03-31 | 2007-12-27 | 에프. 호프만-라 로슈 아게 | 일본 뇌염 바이러스 혈청군의 구성원을 포함하는, 특정플라비바이러스 검출용 조성물 및 방법 |
US7399639B2 (en) * | 2003-05-04 | 2008-07-15 | Massachusetts Institute Of Technology | Sensors, and methods of making and using the same |
US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
US20060029948A1 (en) * | 2003-09-19 | 2006-02-09 | Gary Lim | Sealing cover and dye compatibility selection |
WO2005040357A2 (en) * | 2003-10-24 | 2005-05-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
AU2004297274B2 (en) * | 2003-12-08 | 2009-09-10 | The Research Foundation Of State University Of New York | Site selectively tagged and templated molecularly imprinted polymers for sensor applications |
JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
CN1910444B (zh) * | 2004-01-07 | 2010-04-14 | 纽约州立大学研究基金会 | 分子印迹聚合物、其制备方法和检测分析物存在的方法 |
WO2005077125A2 (en) * | 2004-02-11 | 2005-08-25 | Applera Corporation | Methods and compositions for detecting nucleic acids |
US7939251B2 (en) | 2004-05-06 | 2011-05-10 | Roche Molecular Systems, Inc. | SENP1 as a marker for cancer |
US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
CN103356514A (zh) | 2004-05-28 | 2013-10-23 | 尤尼根公司 | 作为双核酶强效抑制剂的二芳基烷烃 |
US7767834B2 (en) * | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
EP1781675B1 (de) | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Fluoreszierende phosphonatfarbstoffe und konjugate |
US20060252079A1 (en) * | 2005-05-03 | 2006-11-09 | Applera Corporation | Fluorescent detection system and dye set for use therewith |
EP2628727A3 (de) * | 2007-11-21 | 2013-12-25 | Decode Genetics EHF | Biaryl-PDE4-Inhibitoren zur Behandlung von Lungen- und Herz-Kreislauferkrankungen |
CA2730265C (en) | 2008-07-21 | 2016-06-28 | Unigen, Inc. | Series of skin-whitening (lightening) compounds |
KR101718994B1 (ko) * | 2009-09-16 | 2017-03-23 | 포항공과대학교 산학협력단 | 무기 및 유기수은종을 형광을 통하여 감지하는 화학량계의 개발 |
JP5958339B2 (ja) | 2010-06-07 | 2016-07-27 | コニカミノルタ株式会社 | 近接場増強蛍光センサチップ |
EP2607888B1 (de) | 2010-08-17 | 2022-01-12 | Konica Minolta Holdings, Inc. | Spfs-sensor mit einem reinigungsmechanismus für unspezifische adsorptionen |
EP2913408A1 (de) | 2010-12-29 | 2015-09-02 | Life Technologies Corporation | Ddao-verbindungen als fluoreszenzreferenzsandards |
KR101976642B1 (ko) | 2011-03-24 | 2019-05-09 | 유니젠, 인크. | 디아릴프로판의 제조를 위한 화합물 및 방법 |
ES2537189T3 (es) | 2011-05-24 | 2015-06-03 | Elitech Holding B.V. | Detección de estafilococos áureos resistentes a la meticilina |
CN102321063B (zh) * | 2011-07-19 | 2015-07-01 | 华东理工大学 | 一种制备不对称罗丹明的方法 |
US20140170772A1 (en) | 2011-07-28 | 2014-06-19 | Konica Minolta Inc | Method for Measuring Amount of Analyte and Device for SPFS |
CN103012354A (zh) * | 2012-12-24 | 2013-04-03 | 广州医药研究总院 | 5(6)-羧基荧光素异构体的制备方法 |
US20140255928A1 (en) | 2013-03-11 | 2014-09-11 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
ES2654631T3 (es) | 2013-05-13 | 2018-02-14 | Elitechgroup B.V. | PCR digital en gotas con sondas cortas de ranura menor |
CN103508941B (zh) * | 2013-10-29 | 2015-07-22 | 郑州大学 | 2,4-二苯基-5,6-二吡啶基-苯酚及其制备方法 |
US10266903B2 (en) | 2014-12-12 | 2019-04-23 | Elitechgroup, Inc. | Methods and compositions for detecting antibiotic resistant bacteria |
EP3230468B1 (de) | 2014-12-12 | 2020-09-16 | ELITechGroup, Inc. | Verfahren und kits zum nachweis von antibiotikaresistenten bakterien |
US10913944B2 (en) | 2015-01-12 | 2021-02-09 | Life Technologies Corporation | Methods, systems and compositions thereof for nucleic acid library quality control and quantification |
WO2016133218A1 (ja) * | 2015-02-20 | 2016-08-25 | 国立大学法人名古屋大学 | ホスファフルオレセイン化合物若しくはその塩、又はそれを用いた蛍光色素 |
JP7203034B2 (ja) | 2017-10-02 | 2023-01-12 | 大塚製薬株式会社 | アナライトの検出方法 |
EP3898842A1 (de) | 2018-12-20 | 2021-10-27 | Life Technologies Corporation | Modifizierter rhodaminfarbstoff und seine verwendung in biologischen tests |
MX2021007492A (es) | 2018-12-20 | 2021-10-13 | Life Technologies Corp | Colorante de rodamina asimétrica y uso de este en ensayos biológicos. |
WO2021080629A1 (en) | 2019-10-23 | 2021-04-29 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
US20220407014A1 (en) * | 2019-11-08 | 2022-12-22 | The University Of North Carolina At Charlotte | Asymmetric donor-acceptor molecular dyes |
JPWO2021111820A1 (de) | 2019-12-06 | 2021-06-10 | ||
CA3186955A1 (en) | 2020-07-23 | 2022-01-27 | Scott Benson | Energy transfer dye conjugates for use in biological assays |
EP4185858A2 (de) | 2020-07-23 | 2023-05-31 | Life Technologies Corporation | Zusammensetzungen, systeme und verfahren zur biologischen analyse unter verwendung von farbstoffen |
CN113563360A (zh) * | 2021-08-16 | 2021-10-29 | 中国科学技术大学 | 一种两亲性荧光染料及其合成方法和应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US5654442A (en) * | 1989-11-14 | 1997-08-05 | The Perkin-Elmer Corporation | 4,7-dichlorofluorescein dyes as molecular probes |
US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
DE69324494T2 (de) | 1992-09-03 | 1999-09-23 | Perkin Elmer Corp | 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
US5770716A (en) | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
US6130101A (en) * | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
US6008379A (en) * | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
US6221604B1 (en) * | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
-
2000
- 2000-02-07 US US09/498,702 patent/US6221604B1/en not_active Ceased
-
2001
- 2001-02-05 JP JP2001555887A patent/JP2003521571A/ja active Pending
- 2001-02-05 AT AT01907003T patent/ATE258992T1/de not_active IP Right Cessation
- 2001-02-05 WO PCT/US2001/003772 patent/WO2001057264A2/en active IP Right Grant
- 2001-02-05 EP EP01907003A patent/EP1196640B1/de not_active Expired - Lifetime
- 2001-02-05 CA CA002368495A patent/CA2368495C/en not_active Expired - Lifetime
- 2001-02-05 ES ES01907003T patent/ES2211768T3/es not_active Expired - Lifetime
- 2001-02-05 AU AU34839/01A patent/AU772739B2/en not_active Expired
- 2001-02-05 DE DE60101939T patent/DE60101939T2/de not_active Expired - Lifetime
-
2004
- 2004-04-06 US US10/819,078 patent/USRE39663E1/en not_active Expired - Lifetime
-
2005
- 2005-09-02 JP JP2005255770A patent/JP2006070270A/ja not_active Withdrawn
-
2006
- 2006-03-20 JP JP2006077798A patent/JP4942150B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-08 JP JP2007124004A patent/JP2007277564A/ja active Pending
- 2007-05-08 JP JP2007124005A patent/JP2007277565A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2007277564A (ja) | 2007-10-25 |
WO2001057264A2 (en) | 2001-08-09 |
DE60101939T2 (de) | 2005-01-05 |
JP4942150B2 (ja) | 2012-05-30 |
US6221604B1 (en) | 2001-04-24 |
EP1196640A2 (de) | 2002-04-17 |
ATE258992T1 (de) | 2004-02-15 |
CA2368495C (en) | 2009-09-29 |
AU3483901A (en) | 2001-08-14 |
JP2003521571A (ja) | 2003-07-15 |
JP2006257427A (ja) | 2006-09-28 |
USRE39663E1 (en) | 2007-05-29 |
JP2006070270A (ja) | 2006-03-16 |
CA2368495A1 (en) | 2001-08-09 |
JP2007277565A (ja) | 2007-10-25 |
ES2211768T3 (es) | 2004-07-16 |
AU772739B2 (en) | 2004-05-06 |
EP1196640B1 (de) | 2004-02-04 |
WO2001057264A3 (en) | 2002-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |
|
8380 | Miscellaneous part iii |
Free format text: PFANDRECHT AUFGEHOBEN |