DE60100321D1 - Verfahren zur Herstellung von 11-Amino-3-chlor-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]-thiazepin und Anwendung zur Synthese von Thianeptin - Google Patents

Verfahren zur Herstellung von 11-Amino-3-chlor-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]-thiazepin und Anwendung zur Synthese von Thianeptin

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Publication number
DE60100321D1
DE60100321D1 DE60100321T DE60100321T DE60100321D1 DE 60100321 D1 DE60100321 D1 DE 60100321D1 DE 60100321 T DE60100321 T DE 60100321T DE 60100321 T DE60100321 T DE 60100321T DE 60100321 D1 DE60100321 D1 DE 60100321D1
Authority
DE
Germany
Prior art keywords
thianeptine
methyldibenzo
thiazepine
dioxo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60100321T
Other languages
English (en)
Other versions
DE60100321T2 (de
Inventor
Jacky Blanchard
Hugues Turbe
Daniel Brigot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of DE60100321D1 publication Critical patent/DE60100321D1/de
Application granted granted Critical
Publication of DE60100321T2 publication Critical patent/DE60100321T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60100321T 2000-03-31 2001-03-30 Verfahren zur Herstellung von 11-Amino-3-chlor-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]-thiazepin und Anwendung zur Synthese von Thianeptin Expired - Lifetime DE60100321T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004111 2000-03-31
FR0004111A FR2807039A1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE

Publications (2)

Publication Number Publication Date
DE60100321D1 true DE60100321D1 (de) 2003-07-10
DE60100321T2 DE60100321T2 (de) 2004-04-29

Family

ID=8848710

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60100321T Expired - Lifetime DE60100321T2 (de) 2000-03-31 2001-03-30 Verfahren zur Herstellung von 11-Amino-3-chlor-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo[c,f][1,2]-thiazepin und Anwendung zur Synthese von Thianeptin

Country Status (23)

Country Link
US (1) US6441165B2 (de)
EP (1) EP1138677B1 (de)
JP (1) JP3723464B2 (de)
KR (1) KR100464180B1 (de)
CN (1) CN1157387C (de)
AR (1) AR028306A1 (de)
AT (1) ATE242226T1 (de)
AU (1) AU777616B2 (de)
BR (1) BR0101230B1 (de)
CA (1) CA2342950C (de)
DE (1) DE60100321T2 (de)
DK (1) DK1138677T3 (de)
EA (1) EA003770B1 (de)
ES (1) ES2201019T3 (de)
FR (1) FR2807039A1 (de)
HK (1) HK1039618B (de)
HU (1) HU228204B1 (de)
NO (1) NO318088B1 (de)
NZ (1) NZ510857A (de)
PL (1) PL212886B1 (de)
PT (1) PT1138677E (de)
SI (1) SI1138677T1 (de)
ZA (1) ZA200102642B (de)

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Publication number Priority date Publication date Assignee Title
US6683072B1 (en) * 2003-02-04 2004-01-27 Vela Pharmaceuticals, Inc. Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia
JP5599974B2 (ja) * 2005-10-17 2014-10-01 ジェネリクス・［ユーケー］・リミテッド 新規な方法
US9314469B2 (en) 2008-05-05 2016-04-19 Tonix Pharma Holdings Limited Method for treating neurocognitive dysfunction
US8198268B2 (en) 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
WO2010070667A2 (en) * 2008-11-19 2010-06-24 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate
KR101136976B1 (ko) * 2011-09-06 2012-05-30 건일제약 주식회사 티아넵틴 또는 그의 염을 포함하는 탈모증의 예방 또는 치료용 약학 조성물
GB201208315D0 (en) 2012-05-11 2012-06-27 Numedicus Ltd Pharmaceutical methods and compositions
AU2016323977B9 (en) 2015-09-16 2021-03-04 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
CN105254587B (zh) * 2015-10-21 2018-01-09 济南诚汇双达化工有限公司 一种噻萘普汀钠中间体的制备方法
US10961244B2 (en) 2016-03-25 2021-03-30 The Trustees Of Columbia University In The City Of New York Mitragynine alkaloids as opioid receptor modulators
US11787772B2 (en) 2017-03-15 2023-10-17 The Trustees Of Columbia University In The City Of New York Carboxylic diarythiazepineamines as mixed mu- and delta-opioid receptor agonists
CN110790723A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 噻奈普汀钠的合成方法
KR20180101307A (ko) 2018-09-04 2018-09-12 지엘팜텍주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
KR102199871B1 (ko) 2018-12-21 2021-01-08 주식회사 한서켐 3,11-디클로로-6-메틸-6,11-디하이드로디벤조[c,f][1,2]티아제핀 5,5-디옥시드의 제조방법
KR20200104265A (ko) 2020-08-21 2020-09-03 지엘팜텍주식회사 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제
CN112062733A (zh) * 2020-10-30 2020-12-11 南京法恩化学有限公司 一种噻萘普汀钠的制备方法
CN115819375A (zh) * 2022-12-25 2023-03-21 山东诚汇双达药业有限公司 噻奈普汀钠关键中间体的制备方法
CN115872951A (zh) * 2022-12-25 2023-03-31 山东诚汇双达药业有限公司 一种噻奈普汀钠中间体甲氧基取代物的合成方法

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GB1179108A (en) * 1966-12-19 1970-01-28 Science Union & Cie New Derivatives of Dibenzo (c,f) Thiazepine (1,2) and processes for manufacturing them
GB1269551A (en) 1969-03-27 1972-04-06 Science Union & Cie New tricyclic derivatives and process for their manufacture
CA995213A (fr) * 1972-03-16 1976-08-17 Charles Malen Procede de preparation de derives tricycliques
PL106752B1 (pl) * 1976-02-25 1980-01-31 Politechnika Gdanska Sposob otrzymywania nowych 1-nitro-9-alkiloaminoalkiloaminoakrydyn lub ich soli
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
KR890002073A (ko) * 1987-07-01 1989-04-07 원본미기재 나프토티아제핀온
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
JPH05255290A (ja) * 1992-03-17 1993-10-05 Fujisawa Pharmaceut Co Ltd 腫瘍壊死因子産生阻害剤
FR2716623B1 (fr) * 1994-02-25 1996-08-23 Adir Utilisation d'un dérivé tricyclique pour l'obtention de médicaments destinés au traitement des troubles mnémo-cognitifs.
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5886185A (en) * 1997-11-20 1999-03-23 Development Center For Biotechnoloy Polyamine-linked acridine dimers
GB2339778A (en) * 1998-07-17 2000-02-09 Secr Defence Terphenyl Liquid Crystals

Also Published As

Publication number Publication date
NO318088B1 (no) 2005-01-31
HU0101334D0 (en) 2001-06-28
AU777616B2 (en) 2004-10-21
AR028306A1 (es) 2003-05-07
NO20011598L (no) 2001-10-01
PL346793A1 (en) 2001-10-08
ATE242226T1 (de) 2003-06-15
CA2342950C (fr) 2007-05-08
ES2201019T3 (es) 2004-03-16
EA200100301A2 (ru) 2001-10-22
SI1138677T1 (en) 2003-10-31
EA003770B1 (ru) 2003-08-28
HK1039618A1 (en) 2002-05-03
NZ510857A (en) 2001-08-31
HU228204B1 (en) 2013-01-28
FR2807039A1 (fr) 2001-10-05
AU3336801A (en) 2001-10-04
EP1138677B1 (de) 2003-06-04
PT1138677E (pt) 2003-09-30
HK1039618B (zh) 2004-12-31
DE60100321T2 (de) 2004-04-29
CA2342950A1 (fr) 2001-09-30
CN1157387C (zh) 2004-07-14
DK1138677T3 (da) 2003-09-29
BR0101230B1 (pt) 2013-12-24
JP2001316380A (ja) 2001-11-13
KR100464180B1 (ko) 2004-12-31
KR20010095040A (ko) 2001-11-03
US6441165B2 (en) 2002-08-27
HUP0101334A2 (hu) 2002-03-28
NO20011598D0 (no) 2001-03-29
PL212886B1 (pl) 2012-12-31
US20010037021A1 (en) 2001-11-01
HUP0101334A3 (en) 2004-11-29
BR0101230A (pt) 2001-10-30
EA200100301A3 (ru) 2001-12-24
ZA200102642B (en) 2001-10-05
EP1138677A1 (de) 2001-10-04
JP3723464B2 (ja) 2005-12-07
CN1319593A (zh) 2001-10-31

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