SI1138677T1 - Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo(c,f)(1,2)-thiazepine and application to the synthesis of tianeptine - Google Patents
Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo(c,f)(1,2)-thiazepine and application to the synthesis of tianeptineInfo
- Publication number
- SI1138677T1 SI1138677T1 SI200130013T SI200130013T SI1138677T1 SI 1138677 T1 SI1138677 T1 SI 1138677T1 SI 200130013 T SI200130013 T SI 200130013T SI 200130013 T SI200130013 T SI 200130013T SI 1138677 T1 SI1138677 T1 SI 1138677T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tianeptine
- thiazepine
- dibenzo
- dioxo
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0004111A FR2807039A1 (fr) | 2000-03-31 | 2000-03-31 | NOUVEAU PROCEDE DE PREPARATION DE LA 11-AMINO-3-CHLORO-6,11- DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO[c,f][1,2]-THIAZEPINE ET APPLICATION A LA SYNTHESE DE LA TIANEPTINE |
EP01400814A EP1138677B1 (fr) | 2000-03-31 | 2001-03-30 | Nouveau procédé de préparation de la 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-méthyl-dibenzo[c,f][1,2]-thiazépine et application à la synthèse de la tianeptine |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1138677T1 true SI1138677T1 (en) | 2003-10-31 |
Family
ID=8848710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200130013T SI1138677T1 (en) | 2000-03-31 | 2001-03-30 | Process for the preparation of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl-dibenzo(c,f)(1,2)-thiazepine and application to the synthesis of tianeptine |
Country Status (23)
Country | Link |
---|---|
US (1) | US6441165B2 (xx) |
EP (1) | EP1138677B1 (xx) |
JP (1) | JP3723464B2 (xx) |
KR (1) | KR100464180B1 (xx) |
CN (1) | CN1157387C (xx) |
AR (1) | AR028306A1 (xx) |
AT (1) | ATE242226T1 (xx) |
AU (1) | AU777616B2 (xx) |
BR (1) | BR0101230B1 (xx) |
CA (1) | CA2342950C (xx) |
DE (1) | DE60100321T2 (xx) |
DK (1) | DK1138677T3 (xx) |
EA (1) | EA003770B1 (xx) |
ES (1) | ES2201019T3 (xx) |
FR (1) | FR2807039A1 (xx) |
HK (1) | HK1039618B (xx) |
HU (1) | HU228204B1 (xx) |
NO (1) | NO318088B1 (xx) |
NZ (1) | NZ510857A (xx) |
PL (1) | PL212886B1 (xx) |
PT (1) | PT1138677E (xx) |
SI (1) | SI1138677T1 (xx) |
ZA (1) | ZA200102642B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683072B1 (en) * | 2003-02-04 | 2004-01-27 | Vela Pharmaceuticals, Inc. | Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia |
ES2570597T3 (es) * | 2005-10-17 | 2016-05-19 | Generics Uk Ltd | Proceso e intermedios para la preparación de Salmeterol |
US9314469B2 (en) | 2008-05-05 | 2016-04-19 | Tonix Pharma Holdings Limited | Method for treating neurocognitive dysfunction |
US8198268B2 (en) | 2008-10-31 | 2012-06-12 | Janssen Biotech, Inc. | Tianeptine sulfate salt forms and methods of making and using the same |
WO2010070667A2 (en) * | 2008-11-19 | 2010-06-24 | Biophore India Pharmaceuticals Pvt. Ltd. | Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate |
KR101136976B1 (ko) * | 2011-09-06 | 2012-05-30 | 건일제약 주식회사 | 티아넵틴 또는 그의 염을 포함하는 탈모증의 예방 또는 치료용 약학 조성물 |
GB201208315D0 (en) | 2012-05-11 | 2012-06-27 | Numedicus Ltd | Pharmaceutical methods and compositions |
AU2016323977B9 (en) | 2015-09-16 | 2021-03-04 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
CN105254587B (zh) * | 2015-10-21 | 2018-01-09 | 济南诚汇双达化工有限公司 | 一种噻萘普汀钠中间体的制备方法 |
WO2017165738A1 (en) | 2016-03-25 | 2017-09-28 | The Trustees Of Columbia University In The City Of New York | Mitragynine alkaloids as opioid receptor modulators |
WO2018170275A1 (en) * | 2017-03-15 | 2018-09-20 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarythiazepineamines as mixed mu-and delta-opioid receptor agonists |
CN110790723A (zh) * | 2018-08-02 | 2020-02-14 | 北京万全德众医药生物技术有限公司 | 噻奈普汀钠的合成方法 |
KR20180101307A (ko) | 2018-09-04 | 2018-09-12 | 지엘팜텍주식회사 | 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제 |
KR102199871B1 (ko) | 2018-12-21 | 2021-01-08 | 주식회사 한서켐 | 3,11-디클로로-6-메틸-6,11-디하이드로디벤조[c,f][1,2]티아제핀 5,5-디옥시드의 제조방법 |
KR20200104265A (ko) | 2020-08-21 | 2020-09-03 | 지엘팜텍주식회사 | 티아넵틴 또는 이의 약제학적으로 허용되는 염을 포함하는 경구투여용 서방성 정제 |
CN112062733A (zh) * | 2020-10-30 | 2020-12-11 | 南京法恩化学有限公司 | 一种噻萘普汀钠的制备方法 |
CN115872951A (zh) * | 2022-12-25 | 2023-03-31 | 山东诚汇双达药业有限公司 | 一种噻奈普汀钠中间体甲氧基取代物的合成方法 |
CN115819375A (zh) * | 2022-12-25 | 2023-03-21 | 山东诚汇双达药业有限公司 | 噻奈普汀钠关键中间体的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1179108A (en) * | 1966-12-19 | 1970-01-28 | Science Union & Cie | New Derivatives of Dibenzo (c,f) Thiazepine (1,2) and processes for manufacturing them |
GB1269551A (en) | 1969-03-27 | 1972-04-06 | Science Union & Cie | New tricyclic derivatives and process for their manufacture |
CA995213A (fr) * | 1972-03-16 | 1976-08-17 | Charles Malen | Procede de preparation de derives tricycliques |
PL106752B1 (pl) * | 1976-02-25 | 1980-01-31 | Politechnika Gdanska | Sposob otrzymywania nowych 1-nitro-9-alkiloaminoalkiloaminoakrydyn lub ich soli |
US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
KR890002073A (ko) * | 1987-07-01 | 1989-04-07 | 원본미기재 | 나프토티아제핀온 |
RU2024509C1 (ru) * | 1991-05-07 | 1994-12-15 | Всероссийский научный центр по безопасности биологически активных веществ | Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность |
JPH05255290A (ja) * | 1992-03-17 | 1993-10-05 | Fujisawa Pharmaceut Co Ltd | 腫瘍壊死因子産生阻害剤 |
FR2716623B1 (fr) * | 1994-02-25 | 1996-08-23 | Adir | Utilisation d'un dérivé tricyclique pour l'obtention de médicaments destinés au traitement des troubles mnémo-cognitifs. |
US5783584A (en) * | 1995-12-11 | 1998-07-21 | Mayo Foundation For Medical Education And Research | THA analogs useful as cholinesterase inhibitors |
US5886185A (en) * | 1997-11-20 | 1999-03-23 | Development Center For Biotechnoloy | Polyamine-linked acridine dimers |
GB2339778A (en) * | 1998-07-17 | 2000-02-09 | Secr Defence | Terphenyl Liquid Crystals |
-
2000
- 2000-03-31 FR FR0004111A patent/FR2807039A1/fr not_active Withdrawn
-
2001
- 2001-03-28 KR KR10-2001-0016184A patent/KR100464180B1/ko not_active IP Right Cessation
- 2001-03-29 JP JP2001095567A patent/JP3723464B2/ja not_active Expired - Fee Related
- 2001-03-29 CA CA002342950A patent/CA2342950C/fr not_active Expired - Fee Related
- 2001-03-29 BR BRPI0101230-4B1A patent/BR0101230B1/pt not_active IP Right Cessation
- 2001-03-29 NO NO20011598A patent/NO318088B1/no not_active IP Right Cessation
- 2001-03-29 US US09/821,221 patent/US6441165B2/en not_active Expired - Lifetime
- 2001-03-30 AT AT01400814T patent/ATE242226T1/de active
- 2001-03-30 HU HU0101334A patent/HU228204B1/hu not_active IP Right Cessation
- 2001-03-30 ES ES01400814T patent/ES2201019T3/es not_active Expired - Lifetime
- 2001-03-30 NZ NZ510857A patent/NZ510857A/en not_active IP Right Cessation
- 2001-03-30 AR ARP010101536A patent/AR028306A1/es not_active Application Discontinuation
- 2001-03-30 EP EP01400814A patent/EP1138677B1/fr not_active Expired - Lifetime
- 2001-03-30 SI SI200130013T patent/SI1138677T1/xx unknown
- 2001-03-30 PT PT01400814T patent/PT1138677E/pt unknown
- 2001-03-30 ZA ZA200102642A patent/ZA200102642B/xx unknown
- 2001-03-30 CN CNB011120835A patent/CN1157387C/zh not_active Expired - Fee Related
- 2001-03-30 DK DK01400814T patent/DK1138677T3/da active
- 2001-03-30 PL PL346793A patent/PL212886B1/pl unknown
- 2001-03-30 DE DE60100321T patent/DE60100321T2/de not_active Expired - Lifetime
- 2001-03-30 AU AU33368/01A patent/AU777616B2/en not_active Ceased
- 2001-03-30 EA EA200100301A patent/EA003770B1/ru not_active IP Right Cessation
-
2002
- 2002-02-22 HK HK02101326.1A patent/HK1039618B/zh not_active IP Right Cessation
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