DE60042609D1 - Multimere formen von liganden der tnf-superfamilie - Google Patents
Multimere formen von liganden der tnf-superfamilieInfo
- Publication number
- DE60042609D1 DE60042609D1 DE60042609T DE60042609T DE60042609D1 DE 60042609 D1 DE60042609 D1 DE 60042609D1 DE 60042609 T DE60042609 T DE 60042609T DE 60042609 T DE60042609 T DE 60042609T DE 60042609 D1 DE60042609 D1 DE 60042609D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- fusion proteins
- tnfsf
- cells
- cd40l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 108020001507 fusion proteins Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 108010029697 CD40 Ligand Proteins 0.000 abstract 2
- 102100032937 CD40 ligand Human genes 0.000 abstract 2
- 108010007127 Pulmonary Surfactant-Associated Protein D Proteins 0.000 abstract 2
- 102000014128 RANK Ligand Human genes 0.000 abstract 2
- 108010025832 RANK Ligand Proteins 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000012646 vaccine adjuvant Substances 0.000 abstract 2
- 229940124931 vaccine adjuvant Drugs 0.000 abstract 2
- 108090000909 Collectins Proteins 0.000 abstract 1
- 102000004405 Collectins Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100027845 Pulmonary surfactant-associated protein D Human genes 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 231100000057 systemic toxicity Toxicity 0.000 abstract 1
- 239000013638 trimer Substances 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/454,223 US7300774B1 (en) | 1999-12-09 | 1999-12-09 | Multimeric fusion proteins of the TNF superfamily ligands |
| PCT/US2000/007380 WO2001042298A1 (en) | 1999-12-09 | 2000-03-20 | Multimeric forms of tnf superfamily ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60042609D1 true DE60042609D1 (de) | 2009-09-03 |
Family
ID=23803798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60042609T Expired - Lifetime DE60042609D1 (de) | 1999-12-09 | 2000-03-20 | Multimere formen von liganden der tnf-superfamilie |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7300774B1 (de) |
| EP (2) | EP1235853B1 (de) |
| AT (1) | ATE437180T1 (de) |
| AU (1) | AU785297B2 (de) |
| CA (1) | CA2393659C (de) |
| DE (1) | DE60042609D1 (de) |
| DK (1) | DK1235853T3 (de) |
| ES (1) | ES2329334T3 (de) |
| WO (1) | WO2001042298A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7300774B1 (en) * | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US20030013651A1 (en) * | 2001-03-22 | 2003-01-16 | Barnes-Jewish Hospital | Stimulation of osteogenesis using rank ligand fusion proteins |
| CA2441538A1 (en) * | 2001-03-22 | 2002-10-17 | Barnes-Jewish Hospital | Stimulation of osteogenesis using rank ligand fusion proteins |
| US7786282B2 (en) * | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
| EP1560843A4 (de) * | 2002-01-04 | 2006-09-06 | Xencor Inc | Neue varianten von rankl-protein |
| US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
| WO2003057856A2 (en) | 2002-01-04 | 2003-07-17 | Xencor | Dominant negative proteins and methods thereof |
| GB0201679D0 (en) * | 2002-01-25 | 2002-03-13 | Asterion Ltd | Polypeptide variants |
| US7495090B2 (en) * | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
| FR2840307B1 (fr) * | 2002-05-30 | 2006-07-07 | Centre Nat Rech Scient | Nouvelles molecules multimeriques, leur procede de preparation, et leur utilisation pour la preparation de medicaments |
| US20050143297A1 (en) * | 2003-05-26 | 2005-06-30 | Jean-Pierre Rosat | Method for the administration of ligands, agonists of ligands of the TNF family with reduced toxicity |
| EP1736482A1 (de) * | 2005-06-20 | 2006-12-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Rekombinanter trimerer 4-1BB Ligand |
| ES2611307T3 (es) | 2005-08-30 | 2017-05-08 | University Of Miami | Inmunomodulación de agonistas, antagonistas e inmunotoxinas del receptor del factor de necrosis tumoral 25 (TNFR25) |
| EP2066339B1 (de) | 2006-09-18 | 2014-08-13 | The Board Of Trustees Of The University Of Arkansas | Zusammensetzungen und verfahren zur verstärkung von immunreaktionen |
| CA2860950C (en) | 2007-07-10 | 2017-08-01 | Apogenix Gmbh | Tnf superfamily collectin fusion proteins |
| AU2013203061B2 (en) * | 2007-07-10 | 2016-07-28 | Apogenix Ag | TNF superfamily collectin fusion proteins |
| US9125854B2 (en) | 2007-10-30 | 2015-09-08 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to flagellated bacterium |
| EP3097926B1 (de) | 2007-11-01 | 2019-10-02 | The Board of Trustees of the University of Arkansas | Zusammensetzungen und verfahren zur verstärkung von immunreaktionen gegenüber eimeria |
| EP2540740B1 (de) | 2008-06-17 | 2014-09-10 | Apogenix GmbH | Multimere TNF-Rezeptoren |
| US8664366B2 (en) | 2009-01-09 | 2014-03-04 | Apogenix Gmbh | Fusion proteins forming trimers |
| JP2013501057A (ja) | 2009-08-03 | 2013-01-10 | ユニバーシティー・オブ・マイアミ | 制御性ｔ細胞のｉｎｖｉｖｏにおける増殖 |
| JP6242050B2 (ja) | 2010-01-21 | 2017-12-06 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 免疫応答を増強するワクチンベクターおよび方法 |
| WO2011119628A2 (en) | 2010-03-23 | 2011-09-29 | The Regents Of The University Of California | Compositions and methods for self-adjuvanting vaccines against microbes and tumors |
| KR101881611B1 (ko) | 2010-06-09 | 2018-07-25 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 캄필로박터 감염을 감소시키기 위한 백신 및 방법 |
| TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Ｆｃ融合蛋白及其用途 |
| WO2014110258A1 (en) | 2013-01-09 | 2014-07-17 | Podack Eckhard R | Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein |
| US9834610B2 (en) | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
| WO2015116178A1 (en) * | 2014-01-31 | 2015-08-06 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector t cells |
| KR102217499B1 (ko) * | 2013-02-04 | 2021-02-18 | 유니버시티 오브 허더스필드 | Tnfr 길항제와 최소 한 가지 테오레독신 저해제를 포함하는, 암종 치료용 조성물 |
| ES2968398T3 (es) | 2013-02-14 | 2024-05-09 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a Eimeria o limitar la infección por Eimeria |
| DK2970427T3 (da) | 2013-03-15 | 2020-03-09 | Geoffrey W Stone | Sammensætning bestående af antigen bundet til en tnf-superfamilieligand |
| EP3578190A1 (de) | 2013-03-15 | 2019-12-11 | The Board of Trustees of the University of Arkansas | Zusammensetzungen und verfahren zur verstärkung der immunreaktionen gegen enterale pathogene |
| JP2014218510A (ja) * | 2014-08-11 | 2014-11-20 | アポゲニクスゲゼルシャフト ミット ベシュレンクテルハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ | 三量体形成融合タンパク質 |
| MA41460A (fr) * | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| CA3010987A1 (en) | 2016-01-08 | 2017-07-13 | Replimune Limited | Oncolytic herpes simplex virus type 1 strain |
| AR108688A1 (es) | 2016-05-03 | 2018-09-19 | Univ Arkansas | Vector de vacuna de levadura que incluye polipéptidos inmunoestimuladores y antigénicos, métodos para su uso |
| WO2018185247A1 (en) * | 2017-04-06 | 2018-10-11 | Universität Stuttgart | Tumor necrosis factor receptor (tnfr) binding protein complex with improved binding and bioactivity |
| CN114144196B (zh) * | 2019-07-12 | 2024-03-08 | 深圳市华药康明生物药业有限责任公司 | 工程痘苗病毒 |
| CN112552415B (zh) * | 2021-02-22 | 2021-06-22 | 北京百普赛斯生物科技股份有限公司 | B淋巴细胞刺激因子十二聚体及其制备方法与应用 |
| WO2023201201A1 (en) * | 2022-04-10 | 2023-10-19 | Immunomic Therapeutics, Inc. | Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof |
| WO2024003353A1 (en) | 2022-07-01 | 2024-01-04 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68926888T2 (de) | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
| US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| US5962406A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| US5716805A (en) | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| ES2198025T3 (es) | 1991-10-25 | 2004-01-16 | Immunex Corporation | Anticuerpos contra cd40-l. |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| GB9409768D0 (en) | 1994-05-16 | 1994-07-06 | Medical Res Council | Trimerising polypeptides |
| US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
| ES2264207T3 (es) | 1997-07-18 | 2006-12-16 | Zymogenetics, Inc. | Homonologos proteinicos especificos de adipocitos. |
| US7300774B1 (en) * | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| JP2000286319A (ja) | 1999-03-31 | 2000-10-13 | Canon Inc | 基板搬送方法および半導体製造装置 |
| AU6934600A (en) | 1999-08-27 | 2001-03-26 | Board Of Regents, The University Of Texas System | Cd40 ligand and cd40 agonist compositions and methods of use |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US20040248801A1 (en) | 2000-03-21 | 2004-12-09 | Kiessling Laura L. | Methods and reagents for regulation of cellular responses in biological systems |
| GB0015426D0 (en) | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
| AU2003219732A1 (en) | 2002-02-11 | 2003-09-04 | Institut De Recherches Cliniques De Montreal | Oligomeric molecules and uses thereof |
-
1999
- 1999-12-09 US US09/454,223 patent/US7300774B1/en not_active Expired - Lifetime
-
2000
- 2000-03-20 EP EP00919485A patent/EP1235853B1/de not_active Expired - Lifetime
- 2000-03-20 AT AT00919485T patent/ATE437180T1/de active
- 2000-03-20 WO PCT/US2000/007380 patent/WO2001042298A1/en active IP Right Grant
- 2000-03-20 AU AU40167/00A patent/AU785297B2/en not_active Expired
- 2000-03-20 ES ES00919485T patent/ES2329334T3/es not_active Expired - Lifetime
- 2000-03-20 EP EP09009445A patent/EP2128174A1/de not_active Withdrawn
- 2000-03-20 DK DK00919485T patent/DK1235853T3/da active
- 2000-03-20 CA CA2393659A patent/CA2393659C/en not_active Expired - Lifetime
- 2000-03-20 DE DE60042609T patent/DE60042609D1/de not_active Expired - Lifetime
-
2005
- 2005-03-22 US US11/087,348 patent/US7332298B2/en not_active Expired - Lifetime
-
2008
- 2008-02-06 US US12/027,223 patent/US20090263348A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090263348A1 (en) | 2009-10-22 |
| CA2393659C (en) | 2016-01-05 |
| EP1235853B1 (de) | 2009-07-22 |
| US20050158831A1 (en) | 2005-07-21 |
| WO2001042298A1 (en) | 2001-06-14 |
| AU4016700A (en) | 2001-06-18 |
| EP1235853A1 (de) | 2002-09-04 |
| CA2393659A1 (en) | 2001-06-14 |
| DK1235853T3 (da) | 2009-11-23 |
| US7332298B2 (en) | 2008-02-19 |
| US7300774B1 (en) | 2007-11-27 |
| EP2128174A1 (de) | 2009-12-02 |
| AU785297B2 (en) | 2007-01-04 |
| ATE437180T1 (de) | 2009-08-15 |
| EP1235853A4 (de) | 2004-03-31 |
| ES2329334T3 (es) | 2009-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |