DE60029186D1 - Keramischer Schaumkörper - Google Patents

Keramischer Schaumkörper

Info

Publication number
DE60029186D1
DE60029186D1 DE60029186T DE60029186T DE60029186D1 DE 60029186 D1 DE60029186 D1 DE 60029186D1 DE 60029186 T DE60029186 T DE 60029186T DE 60029186 T DE60029186 T DE 60029186T DE 60029186 D1 DE60029186 D1 DE 60029186D1
Authority
DE
Germany
Prior art keywords
foam body
ceramic foam
ceramic body
relates
scaffold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60029186T
Other languages
English (en)
Other versions
DE60029186T2 (de
Inventor
Shihong Li
Groot Klaas De
Pierre Jean Francois Layrolle
Blitterswijk Clemens Anton Van
Wijn Joost Robert De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OctoPlus Sciences BV
Original Assignee
Isotis BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotis BV filed Critical Isotis BV
Publication of DE60029186D1 publication Critical patent/DE60029186D1/de
Application granted granted Critical
Publication of DE60029186T2 publication Critical patent/DE60029186T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/06—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances
    • C04B38/0615—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances the burned-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a porous polyurethane sheet or a prepreg obtained by bonding together resin particles
    • C04B38/062—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances the burned-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a porous polyurethane sheet or a prepreg obtained by bonding together resin particles the burned-out substance being formed in situ, e.g. by polymerisation of a prepolymer composition containing ceramic powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/009—Porous or hollow ceramic granular materials, e.g. microballoons
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/06—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances
    • C04B38/0615—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances the burned-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a porous polyurethane sheet or a prepreg obtained by bonding together resin particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Porous Artificial Stone Or Porous Ceramic Products (AREA)
DE60029186T 1999-12-16 2000-12-18 Keramischer Schaumkörper Expired - Fee Related DE60029186T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204378 1999-12-16
EP99204378 1999-12-16

Publications (2)

Publication Number Publication Date
DE60029186D1 true DE60029186D1 (de) 2006-08-17
DE60029186T2 DE60029186T2 (de) 2007-05-31

Family

ID=8241022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029186T Expired - Fee Related DE60029186T2 (de) 1999-12-16 2000-12-18 Keramischer Schaumkörper

Country Status (6)

Country Link
US (1) US6479418B2 (de)
JP (1) JP2001224679A (de)
AT (1) ATE332288T1 (de)
AU (1) AU778651B2 (de)
CA (1) CA2328818A1 (de)
DE (1) DE60029186T2 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776287B1 (fr) * 1998-03-20 2000-05-12 Ceramiques Tech Soc D Materiau ceramique poreux massif homogene
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
DK1305056T3 (da) * 2000-08-04 2008-01-02 Orthogem Ltd Poröst syntetisk knogleimplantat jog fremgangsmåde til dets fremstilling
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
JP3739715B2 (ja) 2002-03-19 2006-01-25 オリンパス株式会社 人工骨および組織工学用担体
US6793678B2 (en) * 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
NL1021137C2 (nl) * 2002-07-23 2004-01-27 Fondel Finance B V Steunelement voor bevestiging aan bot.
BRPI0407142A (pt) 2003-02-14 2006-01-10 Depuy Spine Inc Dispositivo de fusão intervertebral formado in situ
US6993406B1 (en) 2003-04-24 2006-01-31 Sandia Corporation Method for making a bio-compatible scaffold
US20050158535A1 (en) * 2003-05-15 2005-07-21 Miqin Zhang Methods for making porous ceramic structures
GB0311221D0 (en) * 2003-05-15 2003-06-18 Orthogem Ltd Biomaterial
US20040267376A1 (en) * 2003-06-25 2004-12-30 Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd) Ceramic member for medical implant and its production method
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
DE60321571D1 (de) * 2003-09-16 2008-07-24 Olympus Corp Künstlicher Knochen und Trägermaterial zum Gewebeaufbau
EP1680089B1 (de) * 2003-10-22 2013-09-11 Lidds AB Zusammensetzung mit biologisch abbaubaren hydrierenden keramikstoffen für die kontrollierte arzneimittelabgabe
US7186317B2 (en) * 2003-12-12 2007-03-06 Kimberly-Clark Worldwide, Inc. Method for producing soft bulky tissue
US8636802B2 (en) 2004-03-06 2014-01-28 DePuy Synthes Products, LLC Dynamized interspinal implant
DE102004027657A1 (de) * 2004-06-07 2006-02-02 Zow Ag Gekammerter Werkstoff als Implantat, Knochenersatz und allgemein als Werkstoff
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006062518A2 (en) 2004-12-08 2006-06-15 Interpore Spine Ltd. Continuous phase composite for musculoskeletal repair
US20070038303A1 (en) * 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
US8535357B2 (en) 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
US7740794B1 (en) 2005-04-18 2010-06-22 Biomet Sports Medicine, Llc Methods of making a polymer and ceramic composite
US20070036844A1 (en) * 2005-08-01 2007-02-15 Ma Peter X Porous materials having multi-size geometries
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
EP2311505B1 (de) * 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren zur Behandlung von Knochen
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2661179C (en) * 2006-07-19 2014-12-09 Tower Technology Holdings (Pty) Ltd A method of agglomeration
CA2662808A1 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
US20080097618A1 (en) * 2006-10-18 2008-04-24 Kevin Charles Baker Deposition of calcium-phosphate (CaP) and calcium-phosphate with bone morphogenic protein (CaP+BMP) coatings on metallic and polymeric surfaces
EP2462895B1 (de) 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren für Behandlungen von Arthodese
US7981150B2 (en) * 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
WO2008070863A2 (en) 2006-12-07 2008-06-12 Interventional Spine, Inc. Intervertebral implant
CN101610740A (zh) * 2007-01-19 2009-12-23 金文申有限公司 通过粉末模制制成的多孔可降解植入物
AU2008206953A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8114336B2 (en) * 2007-03-16 2012-02-14 Board Of Regents Of The University Of Texas System Methods for increasing the strength and controlling the architecture and composition of ceramic articles
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (ja) 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド 広い表面積を有する医療器具用のコーティング
CA2965384C (en) 2007-08-09 2021-06-22 The Board Of Regents Of The University Of Texas System Bi-layered bone-like scaffolds
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2237748B1 (de) 2008-01-17 2012-09-05 Synthes GmbH Dehnbares bandscheibenimplantat
JP5864106B2 (ja) 2008-02-07 2016-02-17 バイオミメティック セラピューティクス， エルエルシー 仮骨延長のための組成物および方法
CA2720580A1 (en) 2008-04-05 2009-10-08 Synthes Usa, Llc Expandable intervertebral implant
EP2271380B1 (de) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medizinprodukte mit einer beschichtung aus anorganischem material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
EP2303350A2 (de) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprothesen-beschichtung
NZ602861A (en) * 2008-09-09 2014-03-28 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
JP4392460B1 (ja) 2008-11-13 2010-01-06 株式会社カタリメディック 芳香族炭化水素の残留量が低いリン酸カルシウム多孔体
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
KR20110135949A (ko) * 2009-03-05 2011-12-20 바이오미메틱 세라퓨틱스, 인크. 혈소판-유래 성장 인자 조성물 및 골연골성 결함의 치료 방법
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
PT2453934E (pt) 2009-06-18 2013-09-09 Teknimed Método de activação da superfície de biomateriais porosos
US9399086B2 (en) * 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
US9334195B2 (en) * 2009-10-28 2016-05-10 Universita Degli Studi Di Roma “Tor Vergata” Fabrication of dual structure ceramics by a single step process
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
AU2011217784B2 (en) 2010-02-22 2014-10-09 Biomimetic Therapeutics, Llc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
DK2569342T3 (da) 2010-05-11 2022-04-19 Howmedica Osteonics Corp Multivalente organofosformetalforbindelser og interpenetrerende polymerklæbemiddelnetværkssammensætninger og fremgangsmåder
US9282979B2 (en) 2010-06-24 2016-03-15 DePuy Synthes Products, Inc. Instruments and methods for non-parallel disc space preparation
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
JP5850930B2 (ja) 2010-06-29 2016-02-03 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 離反椎間インプラント
JP5704557B2 (ja) * 2010-09-27 2015-04-22 オリンパステルモバイオマテリアル株式会社 生体組織補填材とその製造方法
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
CN102335460B (zh) * 2011-10-15 2014-01-29 西安交通大学 基于光固化和凝胶注模的镁合金/生物陶瓷骨支架及其成型方法
CN102327648B (zh) * 2011-10-15 2013-08-14 西安交通大学 一种多孔镁合金/生物陶瓷仿生复合支架及其快速成型方法
US9717601B2 (en) 2013-02-28 2017-08-01 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
CN109688980B (zh) 2016-06-28 2022-06-10 Eit 新兴移植技术股份有限公司 具有关节运动接头的可扩张和角度可调节的椎间笼
JP6995789B2 (ja) 2016-06-28 2022-01-17 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー 拡張可能かつ角度調節可能な椎間ケージ
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
EP3689291B1 (de) * 2017-09-26 2022-08-31 Kuraray Noritake Dental Inc. Dentalfräsrohling und verfahren zu seiner herstellung
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
CN112250470A (zh) * 2020-10-21 2021-01-22 深圳市博迪科技开发有限公司 羟基磷灰石降低电子雾化器具加热体基底脱落粉体的用途
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
US12090064B2 (en) 2022-03-01 2024-09-17 Medos International Sarl Stabilization members for expandable intervertebral implants, and related systems and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1496622A1 (de) 1962-10-04 1969-08-14 Ppg Industries Inc Feuerfestes geschaeumtes Produkt
JPS59190250A (ja) 1983-04-13 1984-10-29 東洋ゴム工業株式会社 セラミツク多孔体の製造法
US4654314A (en) * 1983-07-09 1987-03-31 Sumitomo Cement Co., Ltd. Porous ceramic material and processes for preparing same
JPS60200874A (ja) 1984-03-22 1985-10-11 東洋ゴム工業株式会社 セラミツク発泡体の製法
US5171720A (en) * 1988-09-20 1992-12-15 Asahi Kogaku Kogyo K.K. Porous ceramic sinter and process for producing same
GB2317887A (en) 1996-10-04 1998-04-08 Dytech Corp Ltd Porous ceramic articles; bone cell growth and drug carriers
FR2758988B1 (fr) * 1997-02-05 2000-01-21 S H Ind Procede d'elaboration de substituts osseux synthetiques d'architecture poreuse parfaitement maitrisee
US6283997B1 (en) * 1998-11-13 2001-09-04 The Trustees Of Princeton University Controlled architecture ceramic composites by stereolithography

Also Published As

Publication number Publication date
AU778651B2 (en) 2004-12-16
DE60029186T2 (de) 2007-05-31
US20020037799A1 (en) 2002-03-28
ATE332288T1 (de) 2006-07-15
JP2001224679A (ja) 2001-08-21
US6479418B2 (en) 2002-11-12
AU7231000A (en) 2001-06-21
CA2328818A1 (en) 2001-06-16

Similar Documents

Publication Publication Date Title
ATE332288T1 (de) Keramischer schaumkörper
MY140593A (en) 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
CR7728A (es) Nuevas quinazolinas espirocondensadas y su uso como inhibidores de la fosfodiesterasa
CY1109241T1 (el) Ομοιοπολικα γεφυρωμενα διμερη ινσουλινης
DK0991402T3 (da) Fremgangsmåde til fremstilling af en poly(vinylalkohol)cryogel
ATE249491T1 (de) Offenporige bioabbaubare matrize
MXPA03006093A (es) Derivados de n(fenilsulfonil)glicina y su uso terapeutico.
AU5723601A (en) Joint repair using mesenchymal stem cells
PT1169370E (pt) Solucoes de poliuretano contendo unidades estruturais de alcoxissilano.
PT1133283E (pt) Um metodo de producao de particulas de farmaco
HN2001000217A (es) Nuevos tiadiazoles y oxadiazoles y su uso como inhibidores de fosfodiesterasa - 7
ATE288758T1 (de) Verfahren zur herstellung von polymorphen des clarithromycins
DE60019742D1 (de) Methode zur herstellung einer gemusterten betonoberfläche
ATE202483T1 (de) Immuntolerante prothrombinkomplex-präparation
BR0109975A (pt) Método para produzir ansamitocinas
WO2001044141A3 (en) Porous ceramic body
AU1817902A (en) Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
NO20014585D0 (no) Perfluoralkylamider, deres fremstilling og deres anvendelse innen diagnostikken
ATE335830T1 (de) Kontrolle der post-transkriptionelle genabschaltung (gene silencing) in pflanzen
DK1140933T3 (da) Fremgangsmåde til fremstilling af N6-substituerede deaza-adenosinderivater
DE50012584D1 (de) Keramikhaltiges dispergat, verfahren zu dessen herstellung und verwendung des dispergates in dickschichtpasten
WO2002024181A3 (en) The use of melatonin for induction of general anesthesia
AR036593A1 (es) Uso de gch y hl en la hiperestimulacion ovarica controlada
DE50008241D1 (de) Metallschaumkörper auf basis von zink
HU0000531D0 (en) Method for the correction of deuteranopia, filter used by the method and procedure for the production of the filter

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ISOTIS N.V., BILTHOVEN, NL

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: OCTOPLUS SCIENCES B.V., LEIDEN, NL

8339 Ceased/non-payment of the annual fee