DE60026491T2 - Melagatran zur behandlung von entzündungen - Google Patents

Melagatran zur behandlung von entzündungen Download PDF

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Publication number
DE60026491T2
DE60026491T2 DE60026491T DE60026491T DE60026491T2 DE 60026491 T2 DE60026491 T2 DE 60026491T2 DE 60026491 T DE60026491 T DE 60026491T DE 60026491 T DE60026491 T DE 60026491T DE 60026491 T2 DE60026491 T2 DE 60026491T2
Authority
DE
Germany
Prior art keywords
melagatran
inflammation
prodrug
treatment
pab
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026491T
Other languages
German (de)
English (en)
Other versions
DE60026491D1 (de
Inventor
Ian Loughborough Kirk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60026491D1 publication Critical patent/DE60026491D1/de
Publication of DE60026491T2 publication Critical patent/DE60026491T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DE60026491T 1999-01-13 2000-01-13 Melagatran zur behandlung von entzündungen Expired - Lifetime DE60026491T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9900070 1999-01-13
SE9900070A SE9900070D0 (sv) 1999-01-13 1999-01-13 New use
PCT/SE2000/000051 WO2000041716A1 (en) 1999-01-13 2000-01-13 New use of melagatran

Publications (2)

Publication Number Publication Date
DE60026491D1 DE60026491D1 (de) 2006-05-04
DE60026491T2 true DE60026491T2 (de) 2006-11-02

Family

ID=20414074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026491T Expired - Lifetime DE60026491T2 (de) 1999-01-13 2000-01-13 Melagatran zur behandlung von entzündungen

Country Status (20)

Country Link
US (3) US6683054B1 (pt)
EP (1) EP1150704B1 (pt)
JP (1) JP2002534477A (pt)
KR (1) KR100701539B1 (pt)
CN (1) CN1170592C (pt)
AT (1) ATE319473T1 (pt)
AU (1) AU767077B2 (pt)
BR (1) BR0007452A (pt)
CA (1) CA2356611A1 (pt)
CY (1) CY1107465T1 (pt)
DE (1) DE60026491T2 (pt)
DK (1) DK1150704T3 (pt)
ES (1) ES2257282T3 (pt)
IL (1) IL143985A0 (pt)
NO (1) NO20013414L (pt)
NZ (1) NZ512713A (pt)
PT (1) PT1150704E (pt)
SE (1) SE9900070D0 (pt)
WO (1) WO2000041716A1 (pt)
ZA (1) ZA200105275B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900070D0 (sv) * 1999-01-13 1999-01-13 Astra Ab New use
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
DE10133786A1 (de) * 2001-07-16 2003-02-06 Boehringer Ingelheim Pharma Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis
SE0103590D0 (sv) * 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
SE0200198D0 (sv) * 2002-01-23 2002-01-23 Astrazeneca Ab New use
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
JP6155187B2 (ja) 2010-03-30 2017-06-28 ヴァーセオン コーポレイション トロンビンの阻害剤としての多置換芳香族化合物
CN108354933A (zh) 2013-03-15 2018-08-03 维颂公司 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途
MX2015011567A (es) 2013-03-15 2016-04-25 Verseon Corp Halogeno-pirazoles como inhibidores de trombina.
CA2960790A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
LT3261639T (lt) 2015-02-27 2022-11-25 Verseon International Corporation Pakaitiniai pirazolo junginiai kaip serino proteazės inhibitoriai
EP3820564A1 (en) 2018-07-13 2021-05-19 Verseon International Corporation Thrombin inhibitors, formulations, and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6042821A (en) * 1995-11-21 2000-03-28 Smithkline Beecham Corporation Method of treating sepsis with chemokines
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9600216D0 (sv) * 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
US5669754A (en) * 1996-04-22 1997-09-23 Advanced Dynamics Corporation Ltd. Method and apparatus for collecting plates
SE9601556D0 (sv) 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9603724D0 (sv) * 1996-10-11 1996-10-11 Astra Ab New pharmaceutical parenteral formulation of a thrombin inhibitor
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
AU760735B2 (en) 1998-09-28 2003-05-22 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
SE9900070D0 (sv) * 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Also Published As

Publication number Publication date
JP2002534477A (ja) 2002-10-15
NZ512713A (en) 2004-10-29
EP1150704B1 (en) 2006-03-08
EP1150704A1 (en) 2001-11-07
CN1170592C (zh) 2004-10-13
CA2356611A1 (en) 2000-07-20
CN1341028A (zh) 2002-03-20
US20080058303A1 (en) 2008-03-06
DE60026491D1 (de) 2006-05-04
DK1150704T3 (da) 2006-06-12
AU2336100A (en) 2000-08-01
IL143985A0 (en) 2002-04-21
BR0007452A (pt) 2001-10-16
KR20010101492A (ko) 2001-11-14
NO20013414D0 (no) 2001-07-10
AU767077B2 (en) 2003-10-30
WO2000041716A1 (en) 2000-07-20
CY1107465T1 (el) 2012-12-19
US20040082518A1 (en) 2004-04-29
ATE319473T1 (de) 2006-03-15
ZA200105275B (en) 2002-09-26
ES2257282T3 (es) 2006-08-01
NO20013414L (no) 2001-07-10
PT1150704E (pt) 2006-06-30
SE9900070D0 (sv) 1999-01-13
US6683054B1 (en) 2004-01-27
KR100701539B1 (ko) 2007-03-30

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