DE60026354T2 - Verfahren zur herstellung von methylcobalamin - Google Patents

Verfahren zur herstellung von methylcobalamin Download PDF

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Publication number
DE60026354T2
DE60026354T2 DE60026354T DE60026354T DE60026354T2 DE 60026354 T2 DE60026354 T2 DE 60026354T2 DE 60026354 T DE60026354 T DE 60026354T DE 60026354 T DE60026354 T DE 60026354T DE 60026354 T2 DE60026354 T2 DE 60026354T2
Authority
DE
Germany
Prior art keywords
cyanocobalamin
hydroxocobalamin
trimethylsulfoxonium
trimethylsulfonium
methylcobalamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026354T
Other languages
German (de)
English (en)
Other versions
DE60026354D1 (de
Inventor
Yoshihiko Kashima-shi HISATAKE
Hiroshi Kashima-gun KURODA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE60026354D1 publication Critical patent/DE60026354D1/de
Publication of DE60026354T2 publication Critical patent/DE60026354T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60026354T 1999-12-09 2000-12-07 Verfahren zur herstellung von methylcobalamin Expired - Lifetime DE60026354T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP35068399 1999-12-09
JP35068399 1999-12-09
JP2000188619 2000-06-23
JP2000188619 2000-06-23
PCT/JP2000/008675 WO2001042271A1 (fr) 1999-12-09 2000-12-07 Procede de production de methylcobalamine

Publications (2)

Publication Number Publication Date
DE60026354D1 DE60026354D1 (de) 2006-04-27
DE60026354T2 true DE60026354T2 (de) 2006-11-09

Family

ID=26579251

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026354T Expired - Lifetime DE60026354T2 (de) 1999-12-09 2000-12-07 Verfahren zur herstellung von methylcobalamin

Country Status (12)

Country Link
US (1) US6657057B2 (US06657057-20031202-C00006.png)
EP (1) EP1236737B1 (US06657057-20031202-C00006.png)
JP (1) JP3948958B2 (US06657057-20031202-C00006.png)
KR (1) KR100694688B1 (US06657057-20031202-C00006.png)
CN (1) CN1170841C (US06657057-20031202-C00006.png)
AT (1) ATE318833T1 (US06657057-20031202-C00006.png)
CA (1) CA2394155C (US06657057-20031202-C00006.png)
DE (1) DE60026354T2 (US06657057-20031202-C00006.png)
DK (1) DK1236737T3 (US06657057-20031202-C00006.png)
ES (1) ES2257339T3 (US06657057-20031202-C00006.png)
TW (1) TW581770B (US06657057-20031202-C00006.png)
WO (1) WO2001042271A1 (US06657057-20031202-C00006.png)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098896A1 (fr) * 2001-06-05 2002-12-12 Eisai Co., Ltd. Procede de production de methylcobalamine
SG166672A1 (en) * 2002-08-06 2010-12-29 Intradigm Corp Methods of down regulating target gene expression in vivo by introduction of interfering rna
ES2264374B1 (es) * 2005-03-23 2007-11-01 Ferrer Internacional, S.A. Procedimiento de fabricacion de la metilcobalamina.
CN100348201C (zh) * 2005-09-29 2007-11-14 周卓和 甲钴胺分散片及其制备方法
WO2012165934A1 (es) * 2011-05-30 2012-12-06 Interquim, S.A. De C.V. Proceso de síntesis de metilcobalamina
CN102391340A (zh) * 2011-10-31 2012-03-28 河北玉星生物工程有限公司 一种甲钴胺的制备方法
CN105218608A (zh) * 2015-10-29 2016-01-06 无锡福祈制药有限公司 一种甲钴胺的制备方法
JP6867409B2 (ja) 2016-07-08 2021-04-28 ヘルステック バイオ アクティブズ，エス．エル．ユー メチルコバラミンの精製方法
CN106349313B (zh) * 2016-08-23 2019-05-14 宁夏泰瑞制药股份有限公司 一种利用氰钴胺合成甲钴胺粗品的方法
CN108546278A (zh) * 2018-03-17 2018-09-18 山东辰龙药业有限公司 甲钴胺的精制方法
DE102018005078A1 (de) 2018-06-26 2020-01-02 Ilma biochem GmbH Verfahren zur Herstellung und Zusammensetzung von stabilisierten Cob(II)alamin- und Cob(II)inamide-Lösungen als Ausgangszubereitungen zur Herstellung von Arzneimitteln, Medizinprodukten, Nahrungsergänzungsmitteln und Kosmetika
CN108948116A (zh) * 2018-08-30 2018-12-07 上海应用技术大学 一种甲钴胺的绿色合成工艺
CN111808158B (zh) * 2020-07-23 2022-12-06 宁夏金维制药股份有限公司 一种维生素b12粗品的制备方法
CN114874276A (zh) * 2022-04-21 2022-08-09 南京工业大学 一种改进的合成甲钴胺的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4538059B1 (US06657057-20031202-C00006.png) * 1967-07-27 1970-12-02
BE759614A (fr) * 1969-12-01 1971-06-01 Glaxo Lab Ltd Elimination d'ions cyanure de solutions de corrinoides
GB1306958A (en) 1970-09-30 1973-02-14 Pierrel Spa Process for the preparation of substituted cobamides
FR2108794B1 (US06657057-20031202-C00006.png) 1970-10-06 1974-04-12 Roussel Uclaf
BE789252A (fr) 1971-11-10 1973-03-26 Boige Jean Procede de fabrication de la methylcobalamine
FR2240232A1 (en) 1973-08-08 1975-03-07 Boige Jean Methylcobalamine prepn from cyanocobalamine - by reduction and methylation using methyl acid oxalate and a metal
US3928320A (en) 1971-11-10 1975-12-23 Jean Boige Process for the preparation of methylcobalamine
US3789211A (en) 1972-07-14 1974-01-29 Marvin Glass & Associates Decorative lighting system
JPS4947899A (US06657057-20031202-C00006.png) 1972-09-18 1974-05-09
JPS5729587B2 (US06657057-20031202-C00006.png) 1973-06-14 1982-06-23
JPS5038120A (US06657057-20031202-C00006.png) 1973-08-09 1975-04-09
JPH08143590A (ja) 1994-11-24 1996-06-04 Meiji Seika Kaisha Ltd 高純度メチルコバラミンの製造方法

Also Published As

Publication number Publication date
ATE318833T1 (de) 2006-03-15
KR100694688B1 (ko) 2007-03-13
CN1409723A (zh) 2003-04-09
KR20030022767A (ko) 2003-03-17
CN1170841C (zh) 2004-10-13
JP3948958B2 (ja) 2007-07-25
WO2001042271A1 (fr) 2001-06-14
DE60026354D1 (de) 2006-04-27
EP1236737A1 (en) 2002-09-04
ES2257339T3 (es) 2006-08-01
CA2394155A1 (en) 2001-06-14
TW581770B (en) 2004-04-01
US20020183511A1 (en) 2002-12-05
DK1236737T3 (da) 2006-06-19
EP1236737B1 (en) 2006-03-01
US6657057B2 (en) 2003-12-02
CA2394155C (en) 2008-01-15
EP1236737A4 (en) 2003-02-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP