DE60022163D1 - Verfahren zur herstellung von zur agglomeration geeigneten partikeln - Google Patents

Verfahren zur herstellung von zur agglomeration geeigneten partikeln

Info

Publication number
DE60022163D1
DE60022163D1 DE60022163T DE60022163T DE60022163D1 DE 60022163 D1 DE60022163 D1 DE 60022163D1 DE 60022163 T DE60022163 T DE 60022163T DE 60022163 T DE60022163 T DE 60022163T DE 60022163 D1 DE60022163 D1 DE 60022163D1
Authority
DE
Germany
Prior art keywords
suited
particles
preparing agglomeration
agglomeration
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60022163T
Other languages
English (en)
Other versions
DE60022163T2 (de
Inventor
Tsong-Toh Yang
K Yu
G Eckhart
B Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE60022163D1 publication Critical patent/DE60022163D1/de
Application granted granted Critical
Publication of DE60022163T2 publication Critical patent/DE60022163T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Silicon Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
DE60022163T 1999-01-28 2000-01-27 Verfahren zur herstellung von zur agglomeration geeigneten partikeln Expired - Lifetime DE60022163T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23948699A 1999-01-28 1999-01-28
US239486 1999-01-28
PCT/US2000/000496 WO2000044352A1 (en) 1999-01-28 2000-01-27 Method of preparing particles for agglomeration

Publications (2)

Publication Number Publication Date
DE60022163D1 true DE60022163D1 (de) 2005-09-29
DE60022163T2 DE60022163T2 (de) 2006-04-13

Family

ID=22902364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022163T Expired - Lifetime DE60022163T2 (de) 1999-01-28 2000-01-27 Verfahren zur herstellung von zur agglomeration geeigneten partikeln

Country Status (13)

Country Link
EP (2) EP1146859B1 (de)
JP (2) JP3946445B2 (de)
CN (2) CN101480376B (de)
AR (1) AR022695A1 (de)
AT (1) ATE302596T1 (de)
AU (1) AU3470000A (de)
CA (1) CA2360649C (de)
DE (1) DE60022163T2 (de)
DK (1) DK1146859T3 (de)
ES (1) ES2248057T3 (de)
HK (1) HK1037137A1 (de)
WO (1) WO2000044352A1 (de)
ZA (1) ZA200104005B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036358A1 (es) * 2001-08-28 2004-09-01 Schering Corp Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma
WO2003075977A2 (en) * 2002-03-05 2003-09-18 Cleveland State University Agglomerated particles for aerosol drug delivery
US20050148563A1 (en) * 2003-09-26 2005-07-07 Schering Corporation Pulmonary disease treatment
EP1691786A1 (de) * 2003-12-04 2006-08-23 Pfizer Products Inc. Multiteilchenförmige zusammensetzungen mit verbesserter stabilität
KR20070119631A (ko) 2005-02-10 2007-12-20 글락소 그룹 리미티드 사전-분류 기술을 이용한 락토오스 제조 공정 및 이로부터제조된 약제 제형

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
CN1149076C (zh) * 1997-03-20 2004-05-12 先灵公司 粉末附聚物的制备方法
GB9808470D0 (en) * 1998-04-22 1998-06-17 Smithkline Beecham Plc Novel process and apparatus

Also Published As

Publication number Publication date
CA2360649C (en) 2005-09-20
JP2002535352A (ja) 2002-10-22
DK1146859T3 (da) 2005-12-19
CN101480376B (zh) 2013-01-16
HK1037137A1 (en) 2002-02-01
DE60022163T2 (de) 2006-04-13
CA2360649A1 (en) 2000-08-03
CN100467014C (zh) 2009-03-11
AR022695A1 (es) 2002-09-04
EP1146859A1 (de) 2001-10-24
ES2248057T3 (es) 2006-03-16
ATE302596T1 (de) 2005-09-15
ZA200104005B (en) 2002-08-16
JP3946445B2 (ja) 2007-07-18
CN101480376A (zh) 2009-07-15
WO2000044352A1 (en) 2000-08-03
EP1146859B1 (de) 2005-08-24
AU3470000A (en) 2000-08-18
JP2006257103A (ja) 2006-09-28
EP1516614A1 (de) 2005-03-23
CN1341013A (zh) 2002-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition