DE60019164D1 - N6 heterocyclische 8-modifizierte adenosinderivate - Google Patents
N6 heterocyclische 8-modifizierte adenosinderivateInfo
- Publication number
- DE60019164D1 DE60019164D1 DE60019164T DE60019164T DE60019164D1 DE 60019164 D1 DE60019164 D1 DE 60019164D1 DE 60019164 T DE60019164 T DE 60019164T DE 60019164 T DE60019164 T DE 60019164T DE 60019164 D1 DE60019164 D1 DE 60019164D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocyclic
- adenosine derivatives
- modified adenosine
- modified
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US454485 | 1982-12-29 | ||
US09/454,485 US6294522B1 (en) | 1999-12-03 | 1999-12-03 | N6 heterocyclic 8-modified adenosine derivatives |
PCT/US2000/042396 WO2001042265A2 (en) | 1999-12-03 | 2000-11-29 | N6 heterocyclic 8-modified adenosine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60019164D1 true DE60019164D1 (de) | 2005-05-04 |
DE60019164T2 DE60019164T2 (de) | 2006-02-02 |
Family
ID=23804799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60019164T Expired - Lifetime DE60019164T2 (de) | 1999-12-03 | 2000-11-29 | N6 heterocyclische 8-modifizierte adenosinderivate |
Country Status (20)
Country | Link |
---|---|
US (2) | US6294522B1 (de) |
EP (1) | EP1237898B1 (de) |
JP (1) | JP4021196B2 (de) |
KR (1) | KR100484987B1 (de) |
CN (1) | CN1195772C (de) |
AR (1) | AR029198A1 (de) |
AT (1) | ATE292140T1 (de) |
AU (1) | AU771242B2 (de) |
CA (1) | CA2394861C (de) |
DE (1) | DE60019164T2 (de) |
ES (1) | ES2236044T3 (de) |
HK (1) | HK1051695B (de) |
IL (2) | IL149651A0 (de) |
MX (1) | MXPA02005318A (de) |
NO (1) | NO323138B1 (de) |
NZ (1) | NZ518736A (de) |
TR (1) | TR200201470T2 (de) |
TW (1) | TWI268923B (de) |
WO (1) | WO2001042265A2 (de) |
ZA (1) | ZA200204379B (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040161844A1 (en) * | 1996-06-06 | 2004-08-19 | Baker Brenda F. | Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation |
US20050118605A9 (en) * | 1996-06-06 | 2005-06-02 | Baker Brenda F. | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation |
US20040171028A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Phosphorous-linked oligomeric compounds and their use in gene modulation |
US20040171032A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Non-phosphorous-linked oligomeric compounds and their use in gene modulation |
US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
US20040161777A1 (en) * | 1996-06-06 | 2004-08-19 | Baker Brenda F. | Modified oligonucleotides for use in RNA interference |
US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US20040171030A1 (en) * | 1996-06-06 | 2004-09-02 | Baker Brenda F. | Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation |
US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
WO2001040799A2 (en) * | 1999-12-03 | 2001-06-07 | Cv Therapeutics, Inc. | Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias |
US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
AU2001238665A1 (en) * | 2000-02-23 | 2001-09-03 | Cv Therapeutics, Inc. | Method of identifying partial agonists of the a2a receptor |
US6995148B2 (en) * | 2001-04-05 | 2006-02-07 | University Of Pittsburgh | Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy |
EP2412716A1 (de) * | 2002-02-19 | 2012-02-01 | Cv Therapeutics, Inc. | Teilweise oder vollständige a1 agonisten |
AU2003259264A1 (en) * | 2002-07-29 | 2004-02-16 | Cv Therapeutics, Inc. | Myocardial perfusion imaging using a2a receptor agonists |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
CA2504694C (en) * | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
EP1560840B1 (de) | 2002-11-05 | 2015-05-06 | Isis Pharmaceuticals, Inc. | Zusammensetzungen, die alternierende 2'-modifizierte nucleoside enthalten, zur verwendung in der genmodulation |
US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
US9150606B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
US20070161582A1 (en) * | 2003-08-08 | 2007-07-12 | Dusan Mijikovic | Pharmaceutical compositions and methods for metabolic modulation |
CA2544678C (en) | 2003-11-05 | 2013-12-31 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
EP1813623B1 (de) * | 2004-09-17 | 2011-11-09 | Kissei Pharmaceutical Co., Ltd. | In der 8-stellung modifiziertes purin-nukleosidderivat und dessen medizinische verwendung |
CN101076343A (zh) * | 2004-10-20 | 2007-11-21 | Cv医药有限公司 | A2a腺苷受体激动剂的应用 |
DK1881823T3 (en) | 2005-05-17 | 2015-03-02 | Sarcode Bioscience Inc | COMPOSITION AND PROCEDURES FOR TREATMENT OF EYE DISORDERS |
EP2581381A3 (de) | 2006-02-03 | 2013-10-30 | Gilead Sciences, Inc. | Verfahren zur Herstellung eines A2A-Adenosin-Rezeptor-Agonisten und seiner Polymorphe |
EP2068850A1 (de) * | 2006-06-22 | 2009-06-17 | Cv Therapeutics, Inc. | Verwendung von a2a-adenosin-rezeptoragonisten bei der behandlung von ischämie |
WO2008028140A1 (en) * | 2006-09-01 | 2008-03-06 | Cv Therapeutics, Inc. | Methods and compositions for increasing patient tolerability during myocardial imaging methods |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
JP2011502101A (ja) * | 2006-09-29 | 2011-01-20 | ギリアード・パロ・アルト・インコーポレイテッド | 肺疾患の病歴を有する患者における心筋画像化法 |
CA2673653A1 (en) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Myocardial perfusion imaging |
MX2010004281A (es) | 2007-10-19 | 2010-09-10 | Sarcode Corp | Composiciones y metodos para el tratamiento de la retinopatia diabetica. |
EP2265124A4 (de) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Aerosolisierte lfa-1-antagonisten zur verwendung bei der lokalen behandlung von immunerkrankungen |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
JP2011521896A (ja) * | 2008-04-15 | 2011-07-28 | サーコード コーポレイション | 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト |
EP2276508A4 (de) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Freisetzung von lfa-1-antagonisten gegen das magen-darm-system |
WO2010037122A1 (en) * | 2008-09-29 | 2010-04-01 | Gilead Palo Alto, Inc. | Combinations of a rate control agent and an a-2-alpha receptor antagonist for use in multidetector computed tomography methods |
US8378105B2 (en) | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
JP6607780B2 (ja) | 2012-07-25 | 2019-11-20 | サルコード・バイオサイエンス・インコーポレイテッド | Lfa−1阻害剤およびその多形 |
CZ308881B6 (cs) * | 2014-12-09 | 2021-08-04 | Univerzita Palackého v Olomouci | 6-aryl-9-glykosylpuriny a jejich použití |
GB201820685D0 (en) * | 2018-12-19 | 2019-01-30 | NuCana plc | Synthesis of 8-chloroadenosine derivatives |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2881164A (en) * | 1955-07-18 | 1959-04-07 | American Cyanamid Co | Ribofuranosyl derivatives of 6-aralkylamino and 6-heterocyclicalkylaminopurines |
US3150124A (en) * | 1962-03-16 | 1964-09-22 | Svarnas George | Synthesis of kinetin glycosides |
JPS57171998A (en) * | 1981-04-15 | 1982-10-22 | Fujisawa Pharmaceut Co Ltd | Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same |
US4616003A (en) * | 1984-10-26 | 1986-10-07 | Warner-Lambert Company | N6 -dihydroxypropyladenosines |
US4755594A (en) * | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
GB8729994D0 (en) * | 1987-12-23 | 1988-02-03 | Glaxo Group Ltd | Chemical compounds |
US5055569A (en) * | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
US5236902A (en) * | 1990-11-26 | 1993-08-17 | The Governors Of The University Of Alberta | Method and probes for detecting nucleoside transporter and method for producing the probes |
US5432164A (en) * | 1991-10-24 | 1995-07-11 | Novo Nordisk A/S | C2,N6 -disubstituted adenosine derivatives |
AU4226693A (en) * | 1992-05-01 | 1993-11-29 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Phosphorothioate derivatives of cyclic AMP analogues |
US5683989A (en) * | 1993-12-17 | 1997-11-04 | Novo Nordisk A/S | Treatment of ischemias by administration of 2,N6 -substituted adenosines |
JPH07324035A (ja) * | 1994-05-30 | 1995-12-12 | L T T Kenkyusho:Kk | 滑膜細胞増殖抑制剤及び慢性関節リウマチ治療剤 |
CA2191245A1 (en) | 1994-06-09 | 1995-12-14 | Kazuo Yamazaki | 4-quinolinone derivative or salt thereof |
US5789416B1 (en) * | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
GB9723566D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
-
1999
- 1999-12-03 US US09/454,485 patent/US6294522B1/en not_active Expired - Lifetime
-
2000
- 2000-11-29 JP JP2001543562A patent/JP4021196B2/ja not_active Expired - Fee Related
- 2000-11-29 WO PCT/US2000/042396 patent/WO2001042265A2/en active IP Right Grant
- 2000-11-29 DE DE60019164T patent/DE60019164T2/de not_active Expired - Lifetime
- 2000-11-29 NZ NZ518736A patent/NZ518736A/en unknown
- 2000-11-29 CA CA002394861A patent/CA2394861C/en not_active Expired - Fee Related
- 2000-11-29 CN CNB008166269A patent/CN1195772C/zh not_active Expired - Fee Related
- 2000-11-29 EP EP00992554A patent/EP1237898B1/de not_active Expired - Lifetime
- 2000-11-29 AU AU45101/01A patent/AU771242B2/en not_active Ceased
- 2000-11-29 AT AT00992554T patent/ATE292140T1/de not_active IP Right Cessation
- 2000-11-29 MX MXPA02005318A patent/MXPA02005318A/es active IP Right Grant
- 2000-11-29 ES ES00992554T patent/ES2236044T3/es not_active Expired - Lifetime
- 2000-11-29 KR KR10-2002-7007096A patent/KR100484987B1/ko not_active IP Right Cessation
- 2000-11-29 IL IL14965100A patent/IL149651A0/xx active IP Right Grant
- 2000-11-29 TR TR2002/01470T patent/TR200201470T2/xx unknown
- 2000-12-01 AR ARP000106396A patent/AR029198A1/es active IP Right Grant
- 2000-12-02 TW TW089125685A patent/TWI268923B/zh not_active IP Right Cessation
-
2001
- 2001-06-14 US US09/881,281 patent/US20020045595A1/en not_active Abandoned
-
2002
- 2002-05-14 IL IL149651A patent/IL149651A/en not_active IP Right Cessation
- 2002-05-30 NO NO20022573A patent/NO323138B1/no not_active IP Right Cessation
- 2002-05-31 ZA ZA200204379A patent/ZA200204379B/xx unknown
-
2003
- 2003-02-28 HK HK03101536.6A patent/HK1051695B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL149651A0 (en) | 2002-11-10 |
HK1051695A1 (en) | 2003-08-15 |
NZ518736A (en) | 2004-02-27 |
ES2236044T3 (es) | 2005-07-16 |
US6294522B1 (en) | 2001-09-25 |
NO20022573D0 (no) | 2002-05-30 |
KR100484987B1 (ko) | 2005-04-22 |
AU771242B2 (en) | 2004-03-18 |
TWI268923B (en) | 2006-12-21 |
NO20022573L (no) | 2002-05-30 |
WO2001042265A2 (en) | 2001-06-14 |
TR200201470T2 (tr) | 2002-12-23 |
AR029198A1 (es) | 2003-06-18 |
IL149651A (en) | 2006-08-20 |
JP2003516413A (ja) | 2003-05-13 |
CN1195772C (zh) | 2005-04-06 |
WO2001042265A3 (en) | 2002-01-03 |
CN1402732A (zh) | 2003-03-12 |
JP4021196B2 (ja) | 2007-12-12 |
HK1051695B (zh) | 2005-06-03 |
EP1237898B1 (de) | 2005-03-30 |
DE60019164T2 (de) | 2006-02-02 |
ZA200204379B (en) | 2003-06-25 |
EP1237898A2 (de) | 2002-09-11 |
US20020045595A1 (en) | 2002-04-18 |
NO323138B1 (no) | 2007-01-08 |
MXPA02005318A (es) | 2002-12-11 |
CA2394861A1 (en) | 2001-06-14 |
ATE292140T1 (de) | 2005-04-15 |
KR20030032906A (ko) | 2003-04-26 |
CA2394861C (en) | 2007-01-30 |
AU4510101A (en) | 2001-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |