DE60018390T2 - Chelatierende verbindungen, ihre komplexe mit paramagnetischen metallen - Google Patents

Chelatierende verbindungen, ihre komplexe mit paramagnetischen metallen Download PDF

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Publication number
DE60018390T2
DE60018390T2 DE60018390T DE60018390T DE60018390T2 DE 60018390 T2 DE60018390 T2 DE 60018390T2 DE 60018390 T DE60018390 T DE 60018390T DE 60018390 T DE60018390 T DE 60018390T DE 60018390 T2 DE60018390 T2 DE 60018390T2
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DE
Germany
Prior art keywords
bis
amino
alkyl
mol
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60018390T
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German (de)
English (en)
Other versions
DE60018390D1 (de
Inventor
Maurizio Franzini
Andrea Beltrami
Luisella Calabi
Alessandro Maiocchi
Mario Virtuani
Lucio Pier ANELLI
Kondareddiar Ramalingam
S. Ramachandran RANGANATHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of DE60018390D1 publication Critical patent/DE60018390D1/de
Publication of DE60018390T2 publication Critical patent/DE60018390T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60018390T 1999-12-21 2000-12-20 Chelatierende verbindungen, ihre komplexe mit paramagnetischen metallen Expired - Lifetime DE60018390T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI992656 1999-12-21
IT1999MI002656A IT1315263B1 (it) 1999-12-21 1999-12-21 Composti chelanti,loro chelati con ioni metallici paramagnetici, loropreparazione ed uso
PCT/EP2000/012977 WO2001046207A1 (en) 1999-12-21 2000-12-20 Chelating compounds, their complexes with paramagnetic metals

Publications (2)

Publication Number Publication Date
DE60018390D1 DE60018390D1 (de) 2005-04-07
DE60018390T2 true DE60018390T2 (de) 2005-12-29

Family

ID=11384156

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60018390T Expired - Lifetime DE60018390T2 (de) 1999-12-21 2000-12-20 Chelatierende verbindungen, ihre komplexe mit paramagnetischen metallen

Country Status (7)

Country Link
US (1) US6509324B1 (https=)
EP (1) EP1155023B1 (https=)
JP (1) JP2003518131A (https=)
AU (1) AU3014801A (https=)
DE (1) DE60018390T2 (https=)
IT (1) IT1315263B1 (https=)
WO (1) WO2001046207A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU782996B2 (en) * 1999-12-23 2005-09-15 Basell Polyolefine Gmbh Transition metal compound, ligand system, catalyst system and the use of the latter for the polymerisation and copolymerisation of olefins
ITMI20011708A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
JP5106107B2 (ja) * 2004-07-02 2012-12-26 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤
US7795094B2 (en) * 2004-09-02 2010-09-14 Micron Technology, Inc. Recessed gate dielectric antifuse
EP1847555A1 (en) * 2006-04-18 2007-10-24 Borealis Technology Oy Multi-branched Polypropylene
WO2008073458A2 (en) 2006-12-11 2008-06-19 Bracco Imaging S.P.A. Fibrin-binding peptides and conjugates thereof
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
US10270465B2 (en) 2015-12-31 2019-04-23 International Business Machines Corporation Data compression in storage clients
US10015274B2 (en) 2015-12-31 2018-07-03 International Business Machines Corporation Enhanced storage clients
IL260957B2 (en) 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
CN110957532A (zh) * 2019-12-25 2020-04-03 惠州市豪鹏科技有限公司 锂离子电池用电解液及包含其的锂离子电池
CN113372384B (zh) * 2020-02-25 2022-10-11 广州平澜医疗科技有限公司 磁共振造影剂及其制备方法和应用
NL2030022B1 (en) * 2021-12-03 2023-06-21 Wisdom Pharmaceutical Co Ltd SYNTHESIS OF mRNA TRANSMITTER

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392242A (en) * 1971-07-26 1975-04-30 Technic Process for producing by electrodeposition bright deposits of gold and its alloys
US4073700A (en) * 1975-03-10 1978-02-14 Weisberg Alfred M Process for producing by electrodeposition bright deposits of gold and its alloys
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
US5733528A (en) * 1993-12-03 1998-03-31 Dibra S.P.A. Paramagnetic chelates for nuclear magnetic resonance diagnosis
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents

Also Published As

Publication number Publication date
EP1155023B1 (en) 2005-03-02
US6509324B1 (en) 2003-01-21
ITMI992656A0 (it) 1999-12-21
IT1315263B1 (it) 2003-02-03
JP2003518131A (ja) 2003-06-03
WO2001046207A1 (en) 2001-06-28
AU3014801A (en) 2001-07-03
DE60018390D1 (de) 2005-04-07
US20030013859A1 (en) 2003-01-16
ITMI992656A1 (it) 2001-06-21
EP1155023A1 (en) 2001-11-21

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