JP2003518131A - キレート化合物、その常磁性金属との錯体 - Google Patents

キレート化合物、その常磁性金属との錯体

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Publication number
JP2003518131A
JP2003518131A JP2001547116A JP2001547116A JP2003518131A JP 2003518131 A JP2003518131 A JP 2003518131A JP 2001547116 A JP2001547116 A JP 2001547116A JP 2001547116 A JP2001547116 A JP 2001547116A JP 2003518131 A JP2003518131 A JP 2003518131A
Authority
JP
Japan
Prior art keywords
bis
amino
acid
compound according
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001547116A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003518131A5 (https=
Inventor
フランツィーニ，マウリツィオ
ベルトラミ，アンドレア
カラビ，ルイセッラ
マイオッチ，アレッサンドロ
ヴィルトゥアーニ，マリオ
アネリ，ピエル・ルチオ
ラマリンガム，コンダレッディアル
ランガナーサン，ラマチャンドラン・エス
Original Assignee
ブラッコ エッセ ピ ア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブラッコ エッセ ピ ア filed Critical ブラッコ エッセ ピ ア
Publication of JP2003518131A publication Critical patent/JP2003518131A/ja
Publication of JP2003518131A5 publication Critical patent/JP2003518131A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2001547116A 1999-12-21 2000-12-20 キレート化合物、その常磁性金属との錯体 Pending JP2003518131A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI002656A IT1315263B1 (it) 1999-12-21 1999-12-21 Composti chelanti,loro chelati con ioni metallici paramagnetici, loropreparazione ed uso
IT99A002656 1999-12-21
PCT/EP2000/012977 WO2001046207A1 (en) 1999-12-21 2000-12-20 Chelating compounds, their complexes with paramagnetic metals

Publications (2)

Publication Number Publication Date
JP2003518131A true JP2003518131A (ja) 2003-06-03
JP2003518131A5 JP2003518131A5 (https=) 2008-06-19

Family

ID=11384156

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001547116A Pending JP2003518131A (ja) 1999-12-21 2000-12-20 キレート化合物、その常磁性金属との錯体

Country Status (7)

Country Link
US (1) US6509324B1 (https=)
EP (1) EP1155023B1 (https=)
JP (1) JP2003518131A (https=)
AU (1) AU3014801A (https=)
DE (1) DE60018390T2 (https=)
IT (1) IT1315263B1 (https=)
WO (1) WO2001046207A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023515413A (ja) * 2020-02-25 2023-04-13 広州平瀾医療科技有限公司 磁気共鳴造影剤及びその製造方法並びに使用

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU782996B2 (en) * 1999-12-23 2005-09-15 Basell Polyolefine Gmbh Transition metal compound, ligand system, catalyst system and the use of the latter for the polymerisation and copolymerisation of olefins
ITMI20011708A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
JP5106107B2 (ja) * 2004-07-02 2012-12-26 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤
US7795094B2 (en) * 2004-09-02 2010-09-14 Micron Technology, Inc. Recessed gate dielectric antifuse
EP1847555A1 (en) * 2006-04-18 2007-10-24 Borealis Technology Oy Multi-branched Polypropylene
WO2008073458A2 (en) 2006-12-11 2008-06-19 Bracco Imaging S.P.A. Fibrin-binding peptides and conjugates thereof
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
US10270465B2 (en) 2015-12-31 2019-04-23 International Business Machines Corporation Data compression in storage clients
US10015274B2 (en) 2015-12-31 2018-07-03 International Business Machines Corporation Enhanced storage clients
IL260957B2 (en) 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
CN110957532A (zh) * 2019-12-25 2020-04-03 惠州市豪鹏科技有限公司 锂离子电池用电解液及包含其的锂离子电池
NL2030022B1 (en) * 2021-12-03 2023-06-21 Wisdom Pharmaceutical Co Ltd SYNTHESIS OF mRNA TRANSMITTER

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392242A (en) * 1971-07-26 1975-04-30 Technic Process for producing by electrodeposition bright deposits of gold and its alloys
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
JPH04217927A (ja) * 1983-01-21 1992-08-07 Schering Ag Ｎｍｒ診断剤
JPH09505819A (ja) * 1993-12-03 1997-06-10 ブラッコ エッセ．ピ．ア． 核磁気共鳴診断用常磁性キレート

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073700A (en) * 1975-03-10 1978-02-14 Weisberg Alfred M Process for producing by electrodeposition bright deposits of gold and its alloys
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1392242A (en) * 1971-07-26 1975-04-30 Technic Process for producing by electrodeposition bright deposits of gold and its alloys
JPH04217927A (ja) * 1983-01-21 1992-08-07 Schering Ag Ｎｍｒ診断剤
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
JPH09505819A (ja) * 1993-12-03 1997-06-10 ブラッコ エッセ．ピ．ア． 核磁気共鳴診断用常磁性キレート

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023515413A (ja) * 2020-02-25 2023-04-13 広州平瀾医療科技有限公司 磁気共鳴造影剤及びその製造方法並びに使用

Also Published As

Publication number Publication date
EP1155023B1 (en) 2005-03-02
US6509324B1 (en) 2003-01-21
ITMI992656A0 (it) 1999-12-21
IT1315263B1 (it) 2003-02-03
WO2001046207A1 (en) 2001-06-28
DE60018390T2 (de) 2005-12-29
AU3014801A (en) 2001-07-03
DE60018390D1 (de) 2005-04-07
US20030013859A1 (en) 2003-01-16
ITMI992656A1 (it) 2001-06-21
EP1155023A1 (en) 2001-11-21

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