DE60005188D1 - Grf-haltige lyophilisierte arzneizusammensetzungen - Google Patents

Grf-haltige lyophilisierte arzneizusammensetzungen

Info

Publication number
DE60005188D1
DE60005188D1 DE60005188T DE60005188T DE60005188D1 DE 60005188 D1 DE60005188 D1 DE 60005188D1 DE 60005188 T DE60005188 T DE 60005188T DE 60005188 T DE60005188 T DE 60005188T DE 60005188 D1 DE60005188 D1 DE 60005188D1
Authority
DE
Germany
Prior art keywords
grf
lyophilized compositions
containing lyophilized
compositions
lyophilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005188T
Other languages
English (en)
Other versions
DE60005188T2 (de
Inventor
Fabrizio Samaritani
Rio Alessandra Del
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of DE60005188D1 publication Critical patent/DE60005188D1/de
Application granted granted Critical
Publication of DE60005188T2 publication Critical patent/DE60005188T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE60005188T 1999-06-30 2000-06-29 Grf-haltige lyophilisierte arzneizusammensetzungen Expired - Lifetime DE60005188T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99112421A EP1064934A1 (de) 1999-06-30 1999-06-30 Gefriergetrocknete GRF-enthaltende Arzneimittel
EP99112421 1999-06-30
PCT/EP2000/006061 WO2001001965A1 (en) 1999-06-30 2000-06-29 Grf-containing lyophilized pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE60005188D1 true DE60005188D1 (de) 2003-10-16
DE60005188T2 DE60005188T2 (de) 2004-04-01

Family

ID=8238452

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60005188T Expired - Lifetime DE60005188T2 (de) 1999-06-30 2000-06-29 Grf-haltige lyophilisierte arzneizusammensetzungen

Country Status (14)

Country Link
US (2) US20060160739A1 (de)
EP (2) EP1064934A1 (de)
JP (1) JP4880845B2 (de)
AR (1) AR024613A1 (de)
AT (1) ATE249207T1 (de)
AU (1) AU778208C (de)
CA (1) CA2374933C (de)
DE (1) DE60005188T2 (de)
DK (1) DK1189600T3 (de)
ES (1) ES2204661T3 (de)
IL (2) IL147413A0 (de)
PT (1) PT1189600E (de)
SI (1) SI1189600T1 (de)
WO (1) WO2001001965A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147731A0 (en) * 2000-05-19 2002-08-14 Bionebraska Inc Peptide pharmaceutical formulations
CA2496687A1 (en) * 2002-09-18 2004-04-01 Centre Hospitalier De L'universite De Montreal (Chum) Ghrh analogues
JP2010523501A (ja) * 2007-04-04 2010-07-15 セラテクノロジーズ インコーポレイティド Ｇｈｒｈ分子の医薬製剤
TWI441915B (zh) * 2007-09-07 2014-06-21 Nisshin Oillio Group Ltd １，３－二飽和－２－不飽和三酸甘油酯的區分方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5822445B2 (ja) * 1982-07-08 1983-05-09 株式会社 ミドリ十字 安定な固体の人血漿コリンエステラ−ゼ製剤の製法
US5385738A (en) * 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
DE3579911D1 (de) * 1984-12-24 1990-10-31 Sumitomo Pharma Stabiles grf-praeparat.
JPH0725696B2 (ja) * 1986-05-29 1995-03-22 株式会社ミドリ十字 プラスミノ−ゲンの安定化方法
US5017557A (en) * 1987-07-24 1991-05-21 Industria Farmaceutica Serono S.P.A. Treatment of infertility with somatotrophin releasing factor
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
DK0463061T3 (da) * 1989-03-17 1993-07-12 Pitman Moore Inc Controlled-release tilførselsindretning til afgivelse af makromolekylære proteiner
JPH0383931A (ja) * 1989-08-29 1991-04-09 Sumitomo Pharmaceut Co Ltd 低刺激性ｇｒｆ経鼻投与製剤
US5132401A (en) * 1989-09-19 1992-07-21 George Washington University, Office Of Sponsored Research MB-35 a peptide enhancing the production of growth hormone and prolactin from the anterior pituitary
JPH04264020A (ja) * 1991-02-18 1992-09-18 Yamanouchi Pharmaceut Co Ltd 安定な凍結乾燥製剤
ES2136620T3 (es) * 1991-04-19 1999-12-01 Lds Technologies Inc Formulaciones de microemulsiones convertibles.
JP3140797B2 (ja) * 1991-04-26 2001-03-05 生化学工業株式会社 安定化コンドロイチナーゼａｂｃ、その保存方法及び治療剤
YU87892A (sh) * 1991-10-01 1995-12-04 Eli Lilly And Company Lilly Corporate Center Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
SI9300468A (en) * 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
JP3083931B2 (ja) 1993-02-24 2000-09-04 大阪瓦斯株式会社 吸収式冷凍機の故障診断システム
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5898030A (en) 1994-06-17 1999-04-27 Applied Research Systems Ars Holding N.V hGH containing pharmaceutical compositions
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
AU716785B2 (en) * 1995-07-27 2000-03-09 Genentech Inc. Stabile isotonic lyophilized protein formulation
EP0880969A1 (de) * 1997-05-28 1998-12-02 Applied Research Systems ARS Holdings N.V. Im physiologischem Medium schwerlösliche pharmazeutische Peptidezusammensetzungen
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
US6759393B1 (en) * 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
JP4330280B2 (ja) 2001-01-12 2009-09-16 株式会社小松製作所 エンジンの燃料噴射制御方法及びその制御装置

Also Published As

Publication number Publication date
JP4880845B2 (ja) 2012-02-22
US20060160739A1 (en) 2006-07-20
EP1189600B1 (de) 2003-09-10
DK1189600T3 (da) 2004-01-26
US8431534B2 (en) 2013-04-30
JP2003503443A (ja) 2003-01-28
AU6266300A (en) 2001-01-22
PT1189600E (pt) 2003-12-31
EP1064934A1 (de) 2001-01-03
ATE249207T1 (de) 2003-09-15
IL147413A0 (en) 2002-08-14
AR024613A1 (es) 2002-10-16
ES2204661T3 (es) 2004-05-01
EP1189600A1 (de) 2002-03-27
DE60005188T2 (de) 2004-04-01
CA2374933A1 (en) 2001-01-11
SI1189600T1 (en) 2003-12-31
WO2001001965A1 (en) 2001-01-11
AU778208B2 (en) 2004-11-25
AU778208C (en) 2006-03-09
CA2374933C (en) 2010-10-12
US20070203069A1 (en) 2007-08-30
IL147413A (en) 2006-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH