DE59307409D1 - Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester - Google Patents
Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylesterInfo
- Publication number
- DE59307409D1 DE59307409D1 DE59307409T DE59307409T DE59307409D1 DE 59307409 D1 DE59307409 D1 DE 59307409D1 DE 59307409 T DE59307409 T DE 59307409T DE 59307409 T DE59307409 T DE 59307409T DE 59307409 D1 DE59307409 D1 DE 59307409D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- isopropylidene
- hydroxy
- dihydroxy
- butyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
- CFRUAOXMCVQMFP-ZJUUUORDSA-N tert-butyl 2-[(4r,6s)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate Chemical compound CC(C)(C)OC(=O)C[C@H]1C[C@@H](CO)OC(C)(C)O1 CFRUAOXMCVQMFP-ZJUUUORDSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE59307409T DE59307409D1 (de) | 1992-07-02 | 1993-06-28 | Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4221658 | 1992-07-02 | ||
| DE59307409T DE59307409D1 (de) | 1992-07-02 | 1993-06-28 | Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE59307409D1 true DE59307409D1 (de) | 1997-10-30 |
Family
ID=6462276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59307409T Expired - Lifetime DE59307409D1 (de) | 1992-07-02 | 1993-06-28 | Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5399722A (enExample) |
| EP (1) | EP0577040B1 (enExample) |
| JP (1) | JP3504960B2 (enExample) |
| AT (1) | ATE158579T1 (enExample) |
| CA (1) | CA2099444C (enExample) |
| DE (1) | DE59307409D1 (enExample) |
| DK (1) | DK0577040T3 (enExample) |
| ES (1) | ES2106926T3 (enExample) |
| GR (1) | GR3025236T3 (enExample) |
| SG (1) | SG44830A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094594B2 (en) | 2000-06-05 | 2006-08-22 | Kaneka Corporation | Process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl] acetic acid derivatives |
| ES2278032T3 (es) | 2001-07-13 | 2007-08-01 | Astrazeneca Uk Limited | Preparacion de compuestos de aminopirimidina. |
| GB0204129D0 (en) * | 2002-02-21 | 2002-04-10 | Novartis Ag | Process for the manufacture of organic compounds |
| RU2325393C2 (ru) * | 2002-02-25 | 2008-05-27 | Байокон Лимитид | Эфиры бороновой кислоты и способ их получения |
| HRP20040888B1 (en) * | 2002-02-25 | 2012-12-31 | Biocon Ltd | Novel boronate esters |
| JP2004035514A (ja) * | 2002-07-05 | 2004-02-05 | Kanegafuchi Chem Ind Co Ltd | 光学活性６−スルホニルオキシメチル−１，３−ジオキサン−４−イル酢酸誘導体の製造法 |
| GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| KR100529703B1 (ko) * | 2002-09-23 | 2005-11-17 | 임광민 | 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법 |
| WO2004060895A1 (ja) * | 2002-12-27 | 2004-07-22 | Sumitomo Chemical Company, Limited | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法 |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| CN101085770B (zh) * | 2006-06-07 | 2012-07-04 | 上海清松制药有限公司 | 一种制备(3r，5s)-3,5,6-三羟基-己酸叔丁酯的方法 |
| GB2474687A (en) * | 2009-10-23 | 2011-04-27 | Phoenix Chemicals Ltd | A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452994A (en) * | 1981-03-02 | 1984-06-05 | G. D. Searle & Co. | Process for isolating organic compounds and lithium salt complexes useful in said process |
| DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
| DE4128345C1 (en) * | 1991-08-27 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process |
-
1993
- 1993-06-28 ES ES93110265T patent/ES2106926T3/es not_active Expired - Lifetime
- 1993-06-28 AT AT93110265T patent/ATE158579T1/de active
- 1993-06-28 DK DK93110265.1T patent/DK0577040T3/da active
- 1993-06-28 DE DE59307409T patent/DE59307409D1/de not_active Expired - Lifetime
- 1993-06-28 SG SG1996008369A patent/SG44830A1/en unknown
- 1993-06-28 EP EP93110265A patent/EP0577040B1/de not_active Expired - Lifetime
- 1993-06-30 JP JP15988893A patent/JP3504960B2/ja not_active Expired - Fee Related
- 1993-06-30 US US08/083,488 patent/US5399722A/en not_active Expired - Lifetime
- 1993-06-30 CA CA002099444A patent/CA2099444C/en not_active Expired - Lifetime
-
1997
- 1997-10-31 GR GR970402872T patent/GR3025236T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG44830A1 (en) | 1997-12-19 |
| EP0577040A2 (de) | 1994-01-05 |
| EP0577040B1 (de) | 1997-09-24 |
| DK0577040T3 (da) | 1998-02-02 |
| ATE158579T1 (de) | 1997-10-15 |
| EP0577040A3 (enExample) | 1994-03-30 |
| CA2099444A1 (en) | 1994-01-03 |
| ES2106926T3 (es) | 1997-11-16 |
| GR3025236T3 (en) | 1998-02-27 |
| JP3504960B2 (ja) | 2004-03-08 |
| CA2099444C (en) | 2005-03-29 |
| JPH0687851A (ja) | 1994-03-29 |
| US5399722A (en) | 1995-03-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE59307409D1 (de) | Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester | |
| ATE178794T1 (de) | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren | |
| DE60037687D1 (de) | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe | |
| DK0450812T3 (da) | Antihypercholesterolemika | |
| ATE177085T1 (de) | Verfahren zur herstellung von alkylimidazolidon (meth)acrylat | |
| ATE194600T1 (de) | Verfahren zur herstellung von alkylimidazolidone acrylate | |
| ATE200079T1 (de) | Verfahren zur herstellung von hiv-proteasehemmern | |
| DE69431824D1 (de) | Verfahren zur Herstellung von Schwefelhaltigen Imidazolderivaten und erhaltene Zwischenprodukte | |
| ATE244224T1 (de) | Verfahren zur umwandlung von 2,4-dichlorpyridinen in 2-aryloxy-4-chlorpyridine | |
| ATE258605T1 (de) | Verfahren zur herstellung von (1r,4s)-2- azabicyclo 2.2.1 hept-5-en-3-on-derivaten | |
| ATE229000T1 (de) | Verfahren zur herstellung von alpha-aminoketonen | |
| DE60107292D1 (de) | Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin | |
| DE60133395D1 (de) | Verfahren zur herstellung von alpha'-chlorketonen | |
| ATE43833T1 (de) | Verfahren zur herstellung des 1'ethoxycarbonyloxyethylestersvon benzylpenicillin. | |
| ATE146183T1 (de) | Verfahren zur herstellung von ribonukleotid- reduktasehemmern | |
| ATE207908T1 (de) | Verfahren zur herstellung von 2-alkoxy-6- (trifluormethyl)-pyrimidin-4-ol | |
| DE59402632D1 (de) | Verfahren zur Herstellung von 3beta-Aminocholansäurederivaten | |
| ATE175199T1 (de) | Verfahren zur herstellung von 2-substituierten 5- chlorimidazol-4-carbaldehyden | |
| ATE169908T1 (de) | Verfahren zur herstellung von gegebenenfalls 2- substituierten 5-chlorimidazol-4-carbaldehyden | |
| DE69416117D1 (de) | Verfahren zur herstellung von kondensierten carbapenemderivaten | |
| ATE208388T1 (de) | Eintopfverfahren zur herstellung von 2- oxazolidinonderivate | |
| ATE135352T1 (de) | 3-keto-hmg-coa reduktase-inhibitoren | |
| ATE215071T1 (de) | Verfahren zur herstellung von prostaglandin e1 | |
| EP0837066A4 (en) | Improved process for producing penicillin g phenyl ester | |
| ATE143367T1 (de) | Verfahren zur herstellung von optisch aktiven 2- alkyl-2,5-diazabicyclo(2.2.1>heptanen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |