DE50015428D1 - Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzen - Google Patents
Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzenInfo
- Publication number
- DE50015428D1 DE50015428D1 DE50015428T DE50015428T DE50015428D1 DE 50015428 D1 DE50015428 D1 DE 50015428D1 DE 50015428 T DE50015428 T DE 50015428T DE 50015428 T DE50015428 T DE 50015428T DE 50015428 D1 DE50015428 D1 DE 50015428D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydrofolic acid
- production
- seeds
- sodium salts
- pure stereoisomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YUZLLMUQUDCVJL-MMFRDWCLSA-N [Na].C(CC[C@@H](C(=O)O)NC(=O)C1=CC=C(NCC2CNC=3N=C(N)NC(=O)C3N2)C=C1)(=O)O Chemical class [Na].C(CC[C@@H](C(=O)O)NC(=O)C1=CC=C(NCC2CNC=3N=C(N)NC(=O)C3N2)C=C1)(=O)O YUZLLMUQUDCVJL-MMFRDWCLSA-N 0.000 title 1
- 238000002425 crystallisation Methods 0.000 title 1
- 230000008025 crystallization Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- -1 tetrahydrofolic acid ester salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01300/99A CH695217A5 (de) | 1999-07-14 | 1999-07-14 | Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure. |
| PCT/EP2000/006647 WO2001004121A1 (de) | 1999-07-14 | 2000-07-12 | Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE50015428D1 true DE50015428D1 (de) | 2008-12-11 |
Family
ID=4207222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50015428T Expired - Lifetime DE50015428D1 (de) | 1999-07-14 | 2000-07-12 | Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6858731B1 (https=) |
| EP (1) | EP1200436B1 (https=) |
| JP (1) | JP4949581B2 (https=) |
| CN (1) | CN1206229C (https=) |
| AT (1) | ATE412654T1 (https=) |
| AU (1) | AU6272700A (https=) |
| CA (1) | CA2378869C (https=) |
| CH (1) | CH695217A5 (https=) |
| DE (1) | DE50015428D1 (https=) |
| DK (1) | DK1200436T3 (https=) |
| ES (1) | ES2316375T3 (https=) |
| PT (1) | PT1200436E (https=) |
| WO (1) | WO2001004121A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
| ITMI20020132A1 (it) | 2002-01-25 | 2003-07-25 | Gmt Fine Chemicals Sa | Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico |
| PT3817812T (pt) | 2018-07-06 | 2023-12-28 | Merck Patent Gmbh | Sal cristalino de acido 5-metil-(68)-tetra-hidrofólico e éster etílico de l-isoleucina |
| CN116836166B (zh) * | 2023-06-30 | 2025-10-31 | 山东师范大学 | 一种叶酸衍生物及其制备方法和防治铁死亡中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS497416A (https=) * | 1972-05-12 | 1974-01-23 | ||
| DE3821875C1 (https=) | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH681303A5 (https=) | 1991-01-16 | 1993-02-26 | Eprova Ag | |
| CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| US5300503A (en) | 1991-11-01 | 1994-04-05 | Fmc Corporation | Insecticidal 4,6-diamino-1,2-dihydro-1,3,5-triazine derivatives |
| US5698693A (en) * | 1992-11-16 | 1997-12-16 | The United States Of America As Represented By The Department Of Health And Human Services | Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives |
| CH686672A5 (de) * | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
| CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
| JP3433301B2 (ja) * | 1993-11-25 | 2003-08-04 | アサヒビール株式会社 | ５，６，７，８−テトラヒドロ−ｄ−ネオプテリンの有機酸塩の製造法 |
-
1999
- 1999-07-14 CH CH01300/99A patent/CH695217A5/de not_active IP Right Cessation
-
2000
- 2000-07-12 WO PCT/EP2000/006647 patent/WO2001004121A1/de not_active Ceased
- 2000-07-12 AT AT00949322T patent/ATE412654T1/de active
- 2000-07-12 EP EP00949322A patent/EP1200436B1/de not_active Expired - Lifetime
- 2000-07-12 DE DE50015428T patent/DE50015428D1/de not_active Expired - Lifetime
- 2000-07-12 AU AU62727/00A patent/AU6272700A/en not_active Abandoned
- 2000-07-12 ES ES00949322T patent/ES2316375T3/es not_active Expired - Lifetime
- 2000-07-12 US US10/030,693 patent/US6858731B1/en not_active Expired - Lifetime
- 2000-07-12 PT PT00949322T patent/PT1200436E/pt unknown
- 2000-07-12 JP JP2001509730A patent/JP4949581B2/ja not_active Expired - Lifetime
- 2000-07-12 CA CA002378869A patent/CA2378869C/en not_active Expired - Lifetime
- 2000-07-12 CN CNB008102430A patent/CN1206229C/zh not_active Expired - Lifetime
- 2000-07-12 DK DK00949322T patent/DK1200436T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CN1206229C (zh) | 2005-06-15 |
| CN1360586A (zh) | 2002-07-24 |
| JP2003504371A (ja) | 2003-02-04 |
| CA2378869C (en) | 2006-12-12 |
| JP4949581B2 (ja) | 2012-06-13 |
| CA2378869A1 (en) | 2001-01-18 |
| WO2001004121A1 (de) | 2001-01-18 |
| US6858731B1 (en) | 2005-02-22 |
| DK1200436T3 (da) | 2009-02-23 |
| ATE412654T1 (de) | 2008-11-15 |
| AU6272700A (en) | 2001-01-30 |
| EP1200436B1 (de) | 2008-10-29 |
| EP1200436A1 (de) | 2002-05-02 |
| PT1200436E (pt) | 2009-02-10 |
| ES2316375T3 (es) | 2009-04-16 |
| CH695217A5 (de) | 2006-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R082 | Change of representative |
Ref document number: 1200436 Country of ref document: EP Representative=s name: V. FUENER EBBINGHAUS FINCK HANO, DE |
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| R081 | Change of applicant/patentee |
Ref document number: 1200436 Country of ref document: EP Owner name: MERCK & CIE, CH Free format text: FORMER OWNER: MERCK EPROVA AG, SCHAFFHAUSEN, CH Effective date: 20120918 |
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| R082 | Change of representative |
Ref document number: 1200436 Country of ref document: EP Representative=s name: V. FUENER EBBINGHAUS FINCK HANO, DE Effective date: 20120918 |