AU6272700A - Method for making pure stereoisomers of tetrahydrofolic acid ester salts and tetrahydrofolic acid by fractionated crystallisation of tetrahydrofolic acid salts - Google Patents

Method for making pure stereoisomers of tetrahydrofolic acid ester salts and tetrahydrofolic acid by fractionated crystallisation of tetrahydrofolic acid salts

Info

Publication number
AU6272700A
AU6272700A AU62727/00A AU6272700A AU6272700A AU 6272700 A AU6272700 A AU 6272700A AU 62727/00 A AU62727/00 A AU 62727/00A AU 6272700 A AU6272700 A AU 6272700A AU 6272700 A AU6272700 A AU 6272700A
Authority
AU
Australia
Prior art keywords
tetrahydrofolic acid
salts
pure stereoisomers
alphar
alphas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU62727/00A
Other languages
English (en)
Inventor
Viola Groehn
Rudolf Moser
Hans Rudolf Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova AG filed Critical Eprova AG
Publication of AU6272700A publication Critical patent/AU6272700A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU62727/00A 1999-07-14 2000-07-12 Method for making pure stereoisomers of tetrahydrofolic acid ester salts and tetrahydrofolic acid by fractionated crystallisation of tetrahydrofolic acid salts Abandoned AU6272700A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH01300/99A CH695217A5 (de) 1999-07-14 1999-07-14 Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH1300/99 1999-07-14
PCT/EP2000/006647 WO2001004121A1 (de) 1999-07-14 2000-07-12 Verfahren zur herstellung reiner stereoisomeren von tetrahydrofolsäureestersalzen und tetrahydrofolsäure durch fraktionierte kristallisation von tetrahydrofolsäureestersalzen

Publications (1)

Publication Number Publication Date
AU6272700A true AU6272700A (en) 2001-01-30

Family

ID=4207222

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62727/00A Abandoned AU6272700A (en) 1999-07-14 2000-07-12 Method for making pure stereoisomers of tetrahydrofolic acid ester salts and tetrahydrofolic acid by fractionated crystallisation of tetrahydrofolic acid salts

Country Status (13)

Country Link
US (1) US6858731B1 (https=)
EP (1) EP1200436B1 (https=)
JP (1) JP4949581B2 (https=)
CN (1) CN1206229C (https=)
AT (1) ATE412654T1 (https=)
AU (1) AU6272700A (https=)
CA (1) CA2378869C (https=)
CH (1) CH695217A5 (https=)
DE (1) DE50015428D1 (https=)
DK (1) DK1200436T3 (https=)
ES (1) ES2316375T3 (https=)
PT (1) PT1200436E (https=)
WO (1) WO2001004121A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
PT3817812T (pt) 2018-07-06 2023-12-28 Merck Patent Gmbh Sal cristalino de acido 5-metil-(68)-tetra-hidrofólico e éster etílico de l-isoleucina
CN116836166B (zh) * 2023-06-30 2025-10-31 山东师范大学 一种叶酸衍生物及其制备方法和防治铁死亡中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS497416A (https=) * 1972-05-12 1974-01-23
DE3821875C1 (https=) 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (https=) 1991-01-16 1993-02-26 Eprova Ag
CH682664A5 (en) * 1991-10-15 1993-10-29 Eprova Ag Stable salts of 5,10-methylene tetrahydrofolate.
US5300503A (en) 1991-11-01 1994-04-05 Fmc Corporation Insecticidal 4,6-diamino-1,2-dihydro-1,3,5-triazine derivatives
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
JP3433301B2 (ja) * 1993-11-25 2003-08-04 アサヒビール株式会社 ５，６，７，８−テトラヒドロ−ｄ−ネオプテリンの有機酸塩の製造法

Also Published As

Publication number Publication date
CN1206229C (zh) 2005-06-15
CN1360586A (zh) 2002-07-24
JP2003504371A (ja) 2003-02-04
CA2378869C (en) 2006-12-12
JP4949581B2 (ja) 2012-06-13
CA2378869A1 (en) 2001-01-18
WO2001004121A1 (de) 2001-01-18
US6858731B1 (en) 2005-02-22
DK1200436T3 (da) 2009-02-23
ATE412654T1 (de) 2008-11-15
EP1200436B1 (de) 2008-10-29
DE50015428D1 (de) 2008-12-11
EP1200436A1 (de) 2002-05-02
PT1200436E (pt) 2009-02-10
ES2316375T3 (es) 2009-04-16
CH695217A5 (de) 2006-01-31

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase