DE4429465A1 - Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde - Google Patents

Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde

Info

Publication number
DE4429465A1
DE4429465A1 DE4429465A DE4429465A DE4429465A1 DE 4429465 A1 DE4429465 A1 DE 4429465A1 DE 4429465 A DE4429465 A DE 4429465A DE 4429465 A DE4429465 A DE 4429465A DE 4429465 A1 DE4429465 A1 DE 4429465A1
Authority
DE
Germany
Prior art keywords
alkyl
cyan
halogen
mol
hetaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4429465A
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE4429465A priority Critical patent/DE4429465A1/de
Priority to DE59502572T priority patent/DE59502572D1/de
Priority to ES95112442T priority patent/ES2118481T3/es
Priority to EP95112442A priority patent/EP0702003B1/de
Priority to CA002156230A priority patent/CA2156230A1/en
Priority to JP7229616A priority patent/JPH0859619A/ja
Publication of DE4429465A1 publication Critical patent/DE4429465A1/de
Priority to US08/758,625 priority patent/US5708180A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE4429465A 1994-08-19 1994-08-19 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde Withdrawn DE4429465A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE4429465A DE4429465A1 (de) 1994-08-19 1994-08-19 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
DE59502572T DE59502572D1 (de) 1994-08-19 1995-08-08 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden
ES95112442T ES2118481T3 (es) 1994-08-19 1995-08-08 Procedimiento para la obtencion de 2-halogenopiridinaldehidos.
EP95112442A EP0702003B1 (de) 1994-08-19 1995-08-08 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden
CA002156230A CA2156230A1 (en) 1994-08-19 1995-08-16 Process for the preparation of 2-halogenopyridinealdehydes and novel 2-halogenopyridinealdehydes
JP7229616A JPH0859619A (ja) 1994-08-19 1995-08-16 ２−ハロゲノピリジンアルデヒド類の製造方法および新規な２−ハロゲノピリジンアルデヒド類
US08/758,625 US5708180A (en) 1994-08-19 1996-11-27 Process for the preparation of 2-halogenopyridinealdehydes and novel 2-halogenopyridinealdehydes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4429465A DE4429465A1 (de) 1994-08-19 1994-08-19 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde

Publications (1)

Publication Number Publication Date
DE4429465A1 true DE4429465A1 (de) 1996-02-22

Family

ID=6526101

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4429465A Withdrawn DE4429465A1 (de) 1994-08-19 1994-08-19 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
DE59502572T Expired - Fee Related DE59502572D1 (de) 1994-08-19 1995-08-08 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59502572T Expired - Fee Related DE59502572D1 (de) 1994-08-19 1995-08-08 Verfahren zur Herstellung von 2-Halogenpyridinaldehyden

Country Status (6)

Country Link
US (1) US5708180A (enExample)
EP (1) EP0702003B1 (enExample)
JP (1) JPH0859619A (enExample)
CA (1) CA2156230A1 (enExample)
DE (2) DE4429465A1 (enExample)
ES (1) ES2118481T3 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8138350B2 (en) 2006-07-20 2012-03-20 Bayer Cropscience Ag N′-cyano-N-halogenalkylimidamide derivatives
WO2012152741A1 (de) 2011-05-10 2012-11-15 Bayer Intellectual Property Gmbh Bicyclische (thio)carbonylamidine

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737529B2 (en) * 2002-03-07 2004-05-18 Council Of Scientific And Industrial Research Process for the preparation of 2-chloro-5-methylpyridine-3-carbaldehyde
US6479664B1 (en) 2002-03-18 2002-11-12 Council Of Scientific And Industrial Research Process for the preparation of 2-chloro-5-methylpyridine-3-carbaldehyde
DE60228045D1 (de) * 2002-03-20 2008-09-18 Council Scient Ind Res Verfahren zur Herstellung von 2-Chlor-5-methylpyridin-3-carbaldehyd
MX2009002233A (es) 2006-09-07 2009-03-16 Actelion Pharmaceuticals Ltd Derivados de piridin-4-il como agentes inmunomoduladores.
DK2069335T3 (da) 2006-09-08 2013-02-18 Actelion Pharmaceuticals Ltd Pyridin-3-ylderivater som immunomoduleringsmidler
HRP20140335T1 (hr) 2007-03-16 2014-05-09 Actelion Pharmaceuticals Ltd. Derivati amino-piridina kao agonisti s1p1/edg1-receptora
US20110028448A1 (en) * 2008-03-06 2011-02-03 Martin Bolli Pyridine compounds
KR101615779B1 (ko) 2008-03-07 2016-04-26 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-2-일 유도체
MY153617A (en) 2009-07-16 2015-02-27 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
PL2665720T3 (pl) 2011-01-19 2015-11-30 Idorsia Pharmaceuticals Ltd Pochodne 2-metoksypirydyn-4-ylowe
DK3298008T3 (da) 2015-05-20 2020-02-10 Idorsia Pharmaceuticals Ltd Krystallinsk form af forbindelsen (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propan-1,2-diol

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407483A (enExample) * 1973-06-05 1974-12-09
EP0001473B1 (en) 1977-08-12 1988-07-27 Imperial Chemical Industries Plc Herbicidal halogenomethyl--pyridyloxy-phenoxy-alkanecarboxylic acids and derivatives, and processes of controlling unwanted plants therewith
US4279913A (en) 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
DE3314196A1 (de) 1982-07-16 1983-09-29 CIBA-GEIGY AG, 4002 Basel Heterocyclylaether
US5001138B1 (en) * 1985-02-04 1998-01-20 Bayer Agrochem Kk Heterocyclic compounds
DE3681465D1 (enExample) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
US4757073A (en) 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
WO1992022203A1 (en) * 1991-06-12 1992-12-23 E.I. Du Pont De Nemours And Company Substituted pyridine herbicides
JPH0517475A (ja) 1991-07-09 1993-01-26 Sapporo Breweries Ltd 新規な３，４−ジヒドロ−１，８−ナフチリジン誘導体及びそれを含有する抗気管支喘息薬
US5508410A (en) * 1993-11-30 1996-04-16 Reilly Industries, Inc. Process for preparing 2-halo-5-substituted pyridines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8138350B2 (en) 2006-07-20 2012-03-20 Bayer Cropscience Ag N′-cyano-N-halogenalkylimidamide derivatives
WO2012152741A1 (de) 2011-05-10 2012-11-15 Bayer Intellectual Property Gmbh Bicyclische (thio)carbonylamidine

Also Published As

Publication number Publication date
EP0702003A3 (enExample) 1996-03-27
US5708180A (en) 1998-01-13
ES2118481T3 (es) 1998-09-16
JPH0859619A (ja) 1996-03-05
DE59502572D1 (de) 1998-07-23
EP0702003B1 (de) 1998-06-17
EP0702003A2 (de) 1996-03-20
CA2156230A1 (en) 1996-02-20

Similar Documents

Publication Publication Date Title
DE4429465A1 (de) Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
US5124458A (en) Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosuccinate
EP0174910B1 (de) Verfahren zur Herstellung von 4-Phenyl-pyrrol-derivaten
DE10032587A1 (de) 4-Alkoxy-cyclohexan-1-amino-carbonsäureester und Verfahren zu ihrer Herstellung
EP0438691B1 (de) Verfahren zur Herstellung von substituierten 2-Chlorpyridinen
EP0370317A1 (de) Verfahren zur Herstellung von substituierten 2-Chlorpyridinen
EP0125506A1 (de) 5-(2,6-Dichlor-4-trifluormethyl-phenoxy)-2-nitrobenzaldehyd-diacetacylal
EP0293711B1 (de) Verfahren zur Herstellung von 3-Cyano-4-aryl-pyrrolen
EP0380712B1 (de) Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten
EP0000390A1 (de) Derivate der 2-(2,2-Dihalogenvinyl)-3,3-dimethyl-Cyclopropancarbonsäure und Verfahren zu ihrer Herstellung
DE60009795T2 (de) Synthese von 3-Amino-2-Chlor-4-Methylpyridin aus Malonsäuresäurenitril und Aceton
EP0299277B1 (de) Verfahren zur Herstellung von substituierten Pyridylalkylketonen
EP0600835A1 (de) Verfahren zur Herstellung von Phenylessigsäureester-Derivaten
EP2039678A1 (de) Verfahren zum Herstellen von 4-Aminobut-2-enoliden
EP0592896B1 (de) Verfahren zur Herstellung von 2-substituierten 5-Alkylpyridinen
DE2064096C3 (de) Verfahren zur Herstellung von in 6-Stellmtg substituierten 2,4-Dichlorpyrimidin-S-carbonsSureestern
EP0584491B1 (de) Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen
DD151305A5 (de) Verfahren zur herstellung von 3,3-dimethyl-cyclopropan-1,1,2-tricarbonsaeurederivaten
DE3924682A1 (de) Verfahren zur herstellung von chlorierten nicotinaldehyden
CH628015A5 (de) Verfahren zur decarbalkoxylierung von carbonsaeureestern.
EP0599198A1 (de) Verfahren zur Herstellung von 5-Arylhydantoinen
DE2221771C3 (de) Verfahren zur Herstellung von α-Iminonitrilen
DE69018619T2 (de) Alpha, beta-ungesättigte ketone und ketoximderivat.
EP1392652B1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
EP0411417A1 (de) Verfahren zur Herstellung von Aminomethylenverbindungen

Legal Events

Date Code Title Description
8181 Inventor (new situation)

Free format text: BECK, GUNTHER, DR., 51375 LEVERKUSEN, DE HEITZER, HELMUT, DR., 51381 LEVERKUSEN, DE

8139 Disposal/non-payment of the annual fee