DE4339134A1 - 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate - Google Patents

1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate

Info

Publication number
DE4339134A1
DE4339134A1 DE4339134A DE4339134A DE4339134A1 DE 4339134 A1 DE4339134 A1 DE 4339134A1 DE 4339134 A DE4339134 A DE 4339134A DE 4339134 A DE4339134 A DE 4339134A DE 4339134 A1 DE4339134 A1 DE 4339134A1
Authority
DE
Germany
Prior art keywords
oxo
dihydro
fluoro
cyclopropyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4339134A
Other languages
German (de)
English (en)
Inventor
Uwe Dr Petersen
Thomas Dr Schenke
Stefan Dr Boehm
Rolf Dr Grosser
Klaus-Dieter Dr Bremm
Rainer Dr Endermann
Karl Georg Dr Metzger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE4339134A priority Critical patent/DE4339134A1/de
Priority to TW083109629A priority patent/TW273547B/zh
Priority to HRP4339134.6A priority patent/HRP940833A2/xx
Priority to EP94117335A priority patent/EP0653425A1/de
Priority to US08/336,638 priority patent/US5545642A/en
Priority to CO94051221A priority patent/CO4180605A1/es
Priority to AU77730/94A priority patent/AU681703B2/en
Priority to CA002135548A priority patent/CA2135548A1/en
Priority to PE1994254646A priority patent/PE32395A1/es
Priority to YU65494A priority patent/YU65494A/sh
Priority to NZ264905A priority patent/NZ264905A/en
Priority to JP6301672A priority patent/JPH07188230A/ja
Priority to IL11162494A priority patent/IL111624A0/xx
Priority to SK1371-94A priority patent/SK137194A3/sk
Priority to FI945360A priority patent/FI945360L/fi
Priority to BG99179A priority patent/BG62003B1/bg
Priority to CZ942805A priority patent/CZ280594A3/cs
Priority to LVP-94-217A priority patent/LV11328B/lv
Priority to SV1994000064A priority patent/SV1994000064A/es
Priority to NO944365A priority patent/NO302367B1/no
Priority to ZA949052A priority patent/ZA949052B/xx
Priority to KR1019940029885A priority patent/KR950014114A/ko
Priority to RU94040885/04A priority patent/RU94040885A/ru
Priority to PL94305862A priority patent/PL305862A1/xx
Priority to HU9403288A priority patent/HUT70175A/hu
Priority to EE9400240A priority patent/EE9400240A/xx
Priority to CN94118475A priority patent/CN1106412A/zh
Publication of DE4339134A1 publication Critical patent/DE4339134A1/de
Priority to AU25599/97A priority patent/AU2559997A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE4339134A 1993-11-16 1993-11-16 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate Withdrawn DE4339134A1 (de)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DE4339134A DE4339134A1 (de) 1993-11-16 1993-11-16 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
TW083109629A TW273547B (enExample) 1993-11-16 1994-10-18
HRP4339134.6A HRP940833A2 (en) 1993-11-16 1994-10-26 1-(2-fluorocyclopropyl)-quinoline- and naphthyridone carboxylic acid derivatives
EP94117335A EP0653425A1 (de) 1993-11-16 1994-11-03 1-(2-Fluorcyclopropyl)-chinolon- und naphthyridoncarbonsäure-Derivate, deren Herstellung und deren Verwendung in antibakteriellen Mitteln
US08/336,638 US5545642A (en) 1993-11-16 1994-11-09 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthridonecarboxylic acid
CO94051221A CO4180605A1 (es) 1993-11-16 1994-11-09 Derivados de acidos 1-(2-fluorciclopropil)-quinolon y nafti- ridon carboxilicos
AU77730/94A AU681703B2 (en) 1993-11-16 1994-11-09 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid
CA002135548A CA2135548A1 (en) 1993-11-16 1994-11-10 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid
PE1994254646A PE32395A1 (es) 1993-11-16 1994-11-11 Derivados de acidos 1-(2-fluorciclopropil)-quinolon- y naftiridon carboxilicos
YU65494A YU65494A (sh) 1993-11-16 1994-11-11 Derivati 1-(2-fluorociklopropil)-hinolon i naftiridon-karbonske kiseline
NZ264905A NZ264905A (en) 1993-11-16 1994-11-11 1-(2-fluorocyclopropyl)-7-(hexahydropyrrolopyridinyl)-4-oxoqui noline-3-carboxylic acid derivatives and pharmaceutical compositions therof
JP6301672A JPH07188230A (ja) 1993-11-16 1994-11-11 １−（２−フルオロシクロプロピル）−キノロンカルボン酸および１−（２−フルオロシクロプロピル）−ナフチリドンカルボン酸誘導体
SK1371-94A SK137194A3 (en) 1993-11-16 1994-11-14 1-(2-fluorinecyclopropyl)-quinoline-carboxylic) and 1-(2- -florinecyclopropyl)-naphthyridonecarboxylic acid derivatives, method of their producing and their using in medicines
IL11162494A IL111624A0 (en) 1993-11-16 1994-11-14 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid, their preparation and pharmaceutical compositions containing them
FI945360A FI945360L (fi) 1993-11-16 1994-11-14 1-(2-fluorisyklopropyyli)kinoloni- ja naftyridonikarboksyylihappojohdannaiset
BG99179A BG62003B1 (bg) 1993-11-16 1994-11-14 Производни на 1-(2-флуороциклопропил)-хинолон- инафтиридон- карбонови киселини
KR1019940029885A KR950014114A (ko) 1993-11-16 1994-11-15 1-(2-플루오로시클로프로필)-퀴놀론카르복실산 및 1-(2-플루오로시클로프로필)-나프티리돈카르복실산 유도체
LVP-94-217A LV11328B (en) 1993-11-16 1994-11-15 Derivatives of 1-(2-fluorcyclopropyl)-quinolone and naphthyridine carbonic acids
SV1994000064A SV1994000064A (es) 1993-11-16 1994-11-15 Derivados de acidos 1-(2-fluorciclopropil)-quinolon-naftiridon carboxilicos, ref.le a 29 869-sv.
NO944365A NO302367B1 (no) 1993-11-16 1994-11-15 1-(2-fluorcyklopropyl)-chinolon- og naftyridonkarboksylsyrederivater og deres anvendelse til fremstilling av legemidler og antibakterielle midler
ZA949052A ZA949052B (en) 1993-11-16 1994-11-15 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)- naphthyridonecarboxylic acid
CZ942805A CZ280594A3 (en) 1993-11-16 1994-11-15 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid, process of their preparation and use in medicaments
RU94040885/04A RU94040885A (ru) 1993-11-16 1994-11-15 Производные 1-(-2-фторциклопропил)-хинолон- и нафтиридонкарбоновой кислоты, их изомерные смеси или отдельные изомеры, их фармацевтически приемлемые гидраты и соли и фармацевтическая композиция с антибиотической активностью
PL94305862A PL305862A1 (en) 1993-11-16 1994-11-16 Derivatives of 1-(2-fluorocyclopropylo)-quinolinocarboxylic and-naphtyridonacarboxylic acids, method of obtaining such derivatives and drugs containing them
HU9403288A HUT70175A (en) 1993-11-16 1994-11-16 1-(2-fluorocyclopropyl)-quinolon-and -naphtiridon-carboxylic acid derivatives and pharmaceutical compositions containing the same
EE9400240A EE9400240A (et) 1993-11-16 1994-11-16 1-( 2-fluorotsüklopropüül ) -kinoloon- ja -naftüridoonkarboksüülhappe derivaadid ja nende soolad, nende saamismeetodid ja kasutamine
CN94118475A CN1106412A (zh) 1993-11-16 1994-11-16 1-(2-氟环丙基)喹诺酮甲酸和1-(2-氟环丙基)二氮杂萘酮甲酸的衍生物
AU25599/97A AU2559997A (en) 1993-11-16 1997-06-18 Derivatives of 1-(2-fluorocyclopropyl)-quinolonecarboxylic acid and 1-(2-fluorocyclopropyl)-naphthyridonecarboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4339134A DE4339134A1 (de) 1993-11-16 1993-11-16 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate

Publications (1)

Publication Number Publication Date
DE4339134A1 true DE4339134A1 (de) 1995-05-18

Family

ID=6502741

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4339134A Withdrawn DE4339134A1 (de) 1993-11-16 1993-11-16 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate

Country Status (27)

Country Link
US (1) US5545642A (enExample)
EP (1) EP0653425A1 (enExample)
JP (1) JPH07188230A (enExample)
KR (1) KR950014114A (enExample)
CN (1) CN1106412A (enExample)
AU (2) AU681703B2 (enExample)
BG (1) BG62003B1 (enExample)
CA (1) CA2135548A1 (enExample)
CO (1) CO4180605A1 (enExample)
CZ (1) CZ280594A3 (enExample)
DE (1) DE4339134A1 (enExample)
EE (1) EE9400240A (enExample)
FI (1) FI945360L (enExample)
HR (1) HRP940833A2 (enExample)
HU (1) HUT70175A (enExample)
IL (1) IL111624A0 (enExample)
LV (1) LV11328B (enExample)
NO (1) NO302367B1 (enExample)
NZ (1) NZ264905A (enExample)
PE (1) PE32395A1 (enExample)
PL (1) PL305862A1 (enExample)
RU (1) RU94040885A (enExample)
SK (1) SK137194A3 (enExample)
SV (1) SV1994000064A (enExample)
TW (1) TW273547B (enExample)
YU (1) YU65494A (enExample)
ZA (1) ZA949052B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100236852B1 (ko) * 1992-10-09 2000-03-02 나가야마 오사무 플루오로 퀴놀린 유도체
JP3468244B2 (ja) * 1995-12-22 2003-11-17 ナガセケムテックス株式会社 抗ヘリコバクターピロリ剤
WO1998058928A1 (fr) * 1997-06-23 1998-12-30 Yoshitomi Pharmaceutical Industries, Ltd. Agent prophylactique ou therapeutique contre des maladies attribuables a une infection par des helicobacters
DE10108750A1 (de) 2001-02-23 2002-09-05 Bayer Ag Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren
US7915418B2 (en) * 2003-06-06 2011-03-29 Daiichi Pharmaceutical Co., Ltd. Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274167A (en) * 1989-01-26 1993-12-28 Bayer Aktiengesellschaft Polymeriable optically active (meth) acrylic acid derivatives
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
KR910009331B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 디아자비시클로아민 화합물과 그의 제조방법
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
DE69231422T2 (de) * 1991-05-28 2001-03-29 Daiichi Pharmaceutical Co., Ltd. Pyridoncarbonsäurederivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same

Also Published As

Publication number Publication date
YU65494A (sh) 1997-09-30
AU681703B2 (en) 1997-09-04
BG62003B1 (bg) 1998-12-30
NO944365D0 (no) 1994-11-15
FI945360A7 (fi) 1995-05-17
FI945360L (fi) 1995-05-17
EE9400240A (et) 1996-02-15
NO944365L (no) 1995-05-18
TW273547B (enExample) 1996-04-01
CA2135548A1 (en) 1995-05-17
LV11328A (lv) 1996-06-20
HRP940833A2 (en) 1996-12-31
SK137194A3 (en) 1995-06-07
NZ264905A (en) 1995-11-27
AU7773094A (en) 1995-05-25
NO302367B1 (no) 1998-02-23
PE32395A1 (es) 1995-12-15
CZ280594A3 (en) 1995-08-16
US5545642A (en) 1996-08-13
CN1106412A (zh) 1995-08-09
AU2559997A (en) 1997-09-04
JPH07188230A (ja) 1995-07-25
CO4180605A1 (es) 1995-06-07
EP0653425A1 (de) 1995-05-17
HUT70175A (en) 1995-09-28
HU9403288D0 (en) 1995-01-30
RU94040885A (ru) 1996-11-20
SV1994000064A (es) 1995-05-25
LV11328B (en) 1996-12-20
PL305862A1 (en) 1995-05-29
ZA949052B (en) 1995-07-19
BG99179A (en) 1995-07-28
IL111624A0 (en) 1995-01-24
KR950014114A (ko) 1995-06-15
FI945360A0 (fi) 1994-11-14

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Legal Events

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8139 Disposal/non-payment of the annual fee