DE4003750C2 - - Google Patents
Info
- Publication number
- DE4003750C2 DE4003750C2 DE4003750A DE4003750A DE4003750C2 DE 4003750 C2 DE4003750 C2 DE 4003750C2 DE 4003750 A DE4003750 A DE 4003750A DE 4003750 A DE4003750 A DE 4003750A DE 4003750 C2 DE4003750 C2 DE 4003750C2
- Authority
- DE
- Germany
- Prior art keywords
- aluminum
- gel
- thiocyanate
- ratio
- gels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000499 gel Substances 0.000 claims description 61
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims description 26
- 229910052782 aluminium Inorganic materials 0.000 claims description 24
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 22
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 15
- 230000009974 thixotropic effect Effects 0.000 claims description 9
- 206010052428 Wound Diseases 0.000 claims description 6
- 208000027418 Wounds and injury Diseases 0.000 claims description 6
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 6
- 230000029663 wound healing Effects 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 3
- 206010048038 Wound infection Diseases 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 239000012678 infectious agent Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 230000032683 aging Effects 0.000 claims description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- -1 aluminum hydroxythio cyanate Chemical compound 0.000 description 22
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 17
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 12
- 229940116357 potassium thiocyanate Drugs 0.000 description 11
- 241000222122 Candida albicans Species 0.000 description 10
- 229940095731 candida albicans Drugs 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 230000003641 microbiacidal effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 229940024545 aluminum hydroxide Drugs 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 4
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- CAYKLJBSARHIDI-UHFFFAOYSA-K trichloroalumane;hydrate Chemical compound O.Cl[Al](Cl)Cl CAYKLJBSARHIDI-UHFFFAOYSA-K 0.000 description 4
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- XNDZQQSKSQTQQD-UHFFFAOYSA-N 3-methylcyclohex-2-en-1-ol Chemical compound CC1=CC(O)CCC1 XNDZQQSKSQTQQD-UHFFFAOYSA-N 0.000 description 2
- 241000194031 Enterococcus faecium Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- 241000193985 Streptococcus agalactiae Species 0.000 description 2
- 241000193996 Streptococcus pyogenes Species 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- NNCOOIBIVIODKO-UHFFFAOYSA-N aluminum;hypochlorous acid Chemical compound [Al].ClO NNCOOIBIVIODKO-UHFFFAOYSA-N 0.000 description 2
- QJLDTVCWUDCBME-UHFFFAOYSA-K aluminum;trithiocyanate Chemical class [Al+3].[S-]C#N.[S-]C#N.[S-]C#N QJLDTVCWUDCBME-UHFFFAOYSA-K 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052593 corundum Inorganic materials 0.000 description 2
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- ZCZCOXLLICTZAH-UHFFFAOYSA-N hypothiocyanous acid Chemical compound OSC#N ZCZCOXLLICTZAH-UHFFFAOYSA-N 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 108010009004 proteose-peptone Proteins 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229910001845 yogo sapphire Inorganic materials 0.000 description 2
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 150000004690 nonahydrates Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000002984 plastic foam Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000005533 tritiation Methods 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01C—AMMONIA; CYANOGEN; COMPOUNDS THEREOF
- C01C3/00—Cyanogen; Compounds thereof
- C01C3/20—Thiocyanic acid; Salts thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4003750A DE4003750A1 (de) | 1990-02-08 | 1990-02-08 | Aluminiumhydroxythiocyanat, verfahren zur herstellung derselben sowie verwendung dieser als mikrobizides mittel und zur wundheilung |
AU70283/91A AU7028391A (en) | 1990-02-08 | 1991-02-05 | Aluminum hydroxythiocyanate gels, their preparation, and their use as microbicidal agents and for wound healing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4003750A DE4003750A1 (de) | 1990-02-08 | 1990-02-08 | Aluminiumhydroxythiocyanat, verfahren zur herstellung derselben sowie verwendung dieser als mikrobizides mittel und zur wundheilung |
Publications (2)
Publication Number | Publication Date |
---|---|
DE4003750A1 DE4003750A1 (de) | 1991-08-14 |
DE4003750C2 true DE4003750C2 (enrdf_load_stackoverflow) | 1992-03-05 |
Family
ID=6399678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4003750A Granted DE4003750A1 (de) | 1990-02-08 | 1990-02-08 | Aluminiumhydroxythiocyanat, verfahren zur herstellung derselben sowie verwendung dieser als mikrobizides mittel und zur wundheilung |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU7028391A (enrdf_load_stackoverflow) |
DE (1) | DE4003750A1 (enrdf_load_stackoverflow) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD295551A5 (de) * | 1990-07-25 | 1991-11-07 | Ernst-Moritz-Arndt-Universitaet Greifswald,De | Mittel und verfahren zur entzuendungshemmung bei gleichzeitiger foerderung der reepithelisierung und der unspezifischen lokalen resistenz bei augenerkrankungen |
DE19527820A1 (de) * | 1995-07-28 | 1997-01-30 | Leniger Follert Elfriede Prof | Arzneimittel zur Behandlung von Ulcera, insbesondere bei arteriellen und venösen Durchblutungsstörungen der Extremitäten, bei chronisch venöser Insuffizienz und Lymphödem |
FR2737123A1 (fr) * | 1995-07-28 | 1997-01-31 | Francois Michel Nicolas | Application de l'aluminium et de ses derives a la preparation d'un medicament accelerant la cicatrisation |
DE19725405A1 (de) | 1997-06-17 | 1998-12-24 | Kramer Axel Prof Dr Med Sc | Physiologische Wirkstoffkombination zur Förderung der Abwehrleistung der Haut gegenüber Noxen |
EP1287814A1 (de) * | 2001-09-04 | 2003-03-05 | Kramer, Axel, Prof.Dr.med.habil. | Wirkstoffkombination mit Rhodanid (Thiocyanat) als Hauptwirkstoff |
DE10212265A1 (de) * | 2002-03-20 | 2003-10-02 | Wolfgang Weuffen | Zubereitungen natürlicher pflanzlicher und tierischer Rohstoffe für Lebens-, Arnei- und Körperpflegemittel mit erhöhtem Thiocyanatgehalt |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE42682C (de) * | J. HAUFF in Feuerbach b. Stuttgart | Verfahren zur Herstellung mehrbasischer rhodanwasserstoffsaurer Aluminiumbasen als Beizen | ||
DE391698C (de) * | 1923-01-26 | 1924-03-11 | Rhenania Ver Chemischer Fabrik | Verfahren zur Herstellung eines Desinfektionsmittels |
DE1041933B (de) * | 1957-05-14 | 1958-10-30 | C F Asche & Co Ag | Verfahren zur Herstellung von Aluminiumoxychlorid |
DE1251467B (de) * | 1965-06-05 | 1967-10-05 | Giulini Ges Mit Beschraenkter | Verwendung von Aluminiumchloridoxid-hydratgelen als Verdickungsmittel fuer pharmazeutische und kosmetische Praeparate |
US4355020A (en) * | 1977-11-12 | 1982-10-19 | Bert Kuy | Thixotropic aluminum hydroxide chloride and medical and other applications thereof |
-
1990
- 1990-02-08 DE DE4003750A patent/DE4003750A1/de active Granted
-
1991
- 1991-02-05 AU AU70283/91A patent/AU7028391A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE4003750A1 (de) | 1991-08-14 |
AU7028391A (en) | 1991-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OP8 | Request for examination as to paragraph 44 patent law | ||
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SCHUELKE & MAYR GMBH, 20354 HAMBURG, DE |
|
8339 | Ceased/non-payment of the annual fee |