DE3887585T2 - (Aryl oder heteroaromatische methyl)-2,2'-Bi-1H-Imidazole. - Google Patents

(Aryl oder heteroaromatische methyl)-2,2'-Bi-1H-Imidazole.

Info

Publication number
DE3887585T2
DE3887585T2 DE3887585T DE3887585T DE3887585T2 DE 3887585 T2 DE3887585 T2 DE 3887585T2 DE 3887585 T DE3887585 T DE 3887585T DE 3887585 T DE3887585 T DE 3887585T DE 3887585 T2 DE3887585 T2 DE 3887585T2
Authority
DE
Germany
Prior art keywords
aryl
imidazoles
substituted
heteroaromatic methyl
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3887585T
Other languages
English (en)
Other versions
DE3887585D1 (de
Inventor
Donald P Matthews
James R Mccarthy
Jeffrey P Whitten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3887585D1 publication Critical patent/DE3887585D1/de
Publication of DE3887585T2 publication Critical patent/DE3887585T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE3887585T 1987-07-28 1988-07-25 (Aryl oder heteroaromatische methyl)-2,2'-Bi-1H-Imidazole. Expired - Fee Related DE3887585T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/078,352 US4839375A (en) 1987-07-28 1987-07-28 (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents

Publications (2)

Publication Number Publication Date
DE3887585D1 DE3887585D1 (de) 1994-03-17
DE3887585T2 true DE3887585T2 (de) 1994-05-26

Family

ID=22143494

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887585T Expired - Fee Related DE3887585T2 (de) 1987-07-28 1988-07-25 (Aryl oder heteroaromatische methyl)-2,2'-Bi-1H-Imidazole.

Country Status (19)

Country Link
US (1) US4839375A (de)
EP (1) EP0301456B1 (de)
JP (1) JP2750578B2 (de)
KR (1) KR970011301B1 (de)
CN (1) CN1016173B (de)
AT (1) ATE101151T1 (de)
AU (1) AU605609B2 (de)
CA (1) CA1338786C (de)
DE (1) DE3887585T2 (de)
DK (1) DK420588A (de)
ES (1) ES2063008T3 (de)
FI (1) FI883499A (de)
HU (1) HU202861B (de)
IL (1) IL87217A (de)
NO (1) NO169841C (de)
NZ (1) NZ225561A (de)
PH (1) PH26551A (de)
PT (1) PT88121B (de)
ZA (1) ZA885360B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO328281B1 (no) * 1998-03-20 2010-01-25 Res Inst Petroleum Processing Fremgangsmate for omdannelse av hydrokarbonoljer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283661C (en) * 1984-06-20 1991-04-30 Franz Jansen Imidazolides, process for their preparation and application as intermediates for the synthesis of cytotoxic conjugates
CA1286301C (en) * 1985-11-25 1991-07-16 Donald P. Matthews 2,2'-bi-1h-imidazoles
JP2581556B2 (ja) * 1986-05-06 1997-02-12 メレルダウファーマスーティカルズ インコーポレーテッド 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤

Also Published As

Publication number Publication date
IL87217A (en) 1992-07-15
JP2750578B2 (ja) 1998-05-13
PT88121A (pt) 1989-07-31
JPS6440465A (en) 1989-02-10
ZA885360B (en) 1989-03-29
AU1976588A (en) 1989-02-02
HUT53900A (en) 1990-12-28
DK420588D0 (da) 1988-07-27
NZ225561A (en) 1990-12-21
US4839375A (en) 1989-06-13
NO883322L (no) 1989-01-30
ES2063008T3 (es) 1995-01-01
NO169841B (no) 1992-05-04
AU605609B2 (en) 1991-01-17
EP0301456B1 (de) 1994-02-02
PT88121B (pt) 1995-03-01
KR970011301B1 (ko) 1997-07-09
DK420588A (da) 1989-01-29
EP0301456A2 (de) 1989-02-01
CA1338786C (en) 1996-12-10
NO883322D0 (no) 1988-07-27
DE3887585D1 (de) 1994-03-17
PH26551A (en) 1992-08-19
FI883499A (fi) 1989-01-29
CN1016173B (zh) 1992-04-08
CN1034718A (zh) 1989-08-16
NO169841C (no) 1992-08-12
EP0301456A3 (en) 1990-12-05
KR890002112A (ko) 1989-04-08
HU202861B (en) 1991-04-29
IL87217A0 (en) 1988-12-30
FI883499A0 (fi) 1988-07-25
ATE101151T1 (de) 1994-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee