ATE56211T1 - 2-phenylbenzoxepin-derivat. - Google Patents
2-phenylbenzoxepin-derivat.Info
- Publication number
- ATE56211T1 ATE56211T1 AT87305477T AT87305477T ATE56211T1 AT E56211 T1 ATE56211 T1 AT E56211T1 AT 87305477 T AT87305477 T AT 87305477T AT 87305477 T AT87305477 T AT 87305477T AT E56211 T1 ATE56211 T1 AT E56211T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylbenzoxepin
- derivative
- derivatives
- activity
- plateles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14289886 | 1986-06-20 | ||
| EP87305477A EP0250265B1 (de) | 1986-06-20 | 1987-06-19 | 2-Phenylbenzoxepin-Derivat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE56211T1 true ATE56211T1 (de) | 1990-09-15 |
Family
ID=15326163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87305477T ATE56211T1 (de) | 1986-06-20 | 1987-06-19 | 2-phenylbenzoxepin-derivat. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4845094A (de) |
| EP (1) | EP0250265B1 (de) |
| JP (1) | JPH0813807B2 (de) |
| AT (1) | ATE56211T1 (de) |
| AU (1) | AU597671B2 (de) |
| CA (1) | CA1277320C (de) |
| DE (1) | DE3764724D1 (de) |
| DK (1) | DK166676B1 (de) |
| ES (1) | ES2017498B3 (de) |
| HU (1) | HU206108B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
| JP2851054B2 (ja) * | 1989-03-15 | 1999-01-27 | サントリー株式会社 | ベンズオキセピン誘導体 |
| FR2698873B1 (fr) * | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| WO1996003924A1 (en) * | 1994-08-05 | 1996-02-15 | Chiron Vision Corporation | Device for inserting a flexible intraocular lens |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| EA004877B1 (ru) | 1998-12-23 | 2004-08-26 | Джи.Ди.Сирл Ллс | Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний |
| AU776620B2 (en) | 1998-12-23 | 2004-09-16 | G.D. Searle Llc | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| CA2356157C (en) | 1998-12-23 | 2008-04-01 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| ATE242007T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| ATE240120T1 (de) | 1998-12-23 | 2003-05-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| EP1140185B1 (de) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen |
| AU2001240115A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| WO2003040127A1 (en) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
| CA2471639A1 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| SG11201401849QA (en) | 2011-10-28 | 2014-05-29 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| SG10201406155QA (en) | 2011-10-28 | 2014-11-27 | Lumena Pharmaceuticals Inc | Bile Acid Recycling Inhibitors For Treatment Of Pediatric Cholestatic Liver Diseases |
| WO2016019587A1 (en) * | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [7, 6]-fused bicyclic antidiabetic compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
| DE2931399A1 (de) * | 1979-08-02 | 1981-02-26 | Kali Chemie Pharma Gmbh | Neue 3-amino-1-benzoxepin-derivate und ihre salze, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3440295A1 (de) * | 1984-11-05 | 1986-05-15 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur diastereoselektiven reduktion von 3-amino-1-benzoxepin-5(2h)-onen |
| US4736031A (en) * | 1985-06-10 | 1988-04-05 | Takeda Chemical Industries, Ltd. | 2-(piperazinylalkyl)-1-benzothiepin, 1-benzoxepin, and 1,5-benzodioxepin derivatives |
-
1987
- 1987-06-15 AU AU74245/87A patent/AU597671B2/en not_active Ceased
- 1987-06-18 JP JP62150304A patent/JPH0813807B2/ja not_active Expired - Lifetime
- 1987-06-19 HU HU872809A patent/HU206108B/hu not_active IP Right Cessation
- 1987-06-19 CA CA000540116A patent/CA1277320C/en not_active Expired - Lifetime
- 1987-06-19 AT AT87305477T patent/ATE56211T1/de not_active IP Right Cessation
- 1987-06-19 US US07/063,839 patent/US4845094A/en not_active Expired - Fee Related
- 1987-06-19 ES ES87305477T patent/ES2017498B3/es not_active Expired - Lifetime
- 1987-06-19 EP EP87305477A patent/EP0250265B1/de not_active Expired - Lifetime
- 1987-06-19 DK DK314487A patent/DK166676B1/da active
- 1987-06-19 DE DE8787305477T patent/DE3764724D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0250265B1 (de) | 1990-09-05 |
| HUT48231A (en) | 1989-05-29 |
| EP0250265A1 (de) | 1987-12-23 |
| US4845094A (en) | 1989-07-04 |
| HU206108B (en) | 1992-08-28 |
| JPS63107972A (ja) | 1988-05-12 |
| DE3764724D1 (de) | 1990-10-11 |
| DK166676B1 (da) | 1993-06-28 |
| CA1277320C (en) | 1990-12-04 |
| JPH0813807B2 (ja) | 1996-02-14 |
| AU7424587A (en) | 1987-12-24 |
| AU597671B2 (en) | 1990-06-07 |
| DK314487D0 (da) | 1987-06-19 |
| DK314487A (da) | 1987-12-21 |
| ES2017498B3 (es) | 1991-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |