ES2017498B3 - Derivado de 2-fenilbenzoxepina. - Google Patents

Derivado de 2-fenilbenzoxepina.

Info

Publication number
ES2017498B3
ES2017498B3 ES87305477T ES87305477T ES2017498B3 ES 2017498 B3 ES2017498 B3 ES 2017498B3 ES 87305477 T ES87305477 T ES 87305477T ES 87305477 T ES87305477 T ES 87305477T ES 2017498 B3 ES2017498 B3 ES 2017498B3
Authority
ES
Spain
Prior art keywords
phenylbenzoxepine
derivative
derivatives
activity
phenylbenzoxepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87305477T
Other languages
English (en)
Inventor
Toshio Tatsuoka
Kayoko Nomura
Fumio Satoh
Takafumi Ishihara
Seiji Miyano
Kunihiro Sumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2017498B3 publication Critical patent/ES2017498B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
ES87305477T 1986-06-20 1987-06-19 Derivado de 2-fenilbenzoxepina. Expired - Lifetime ES2017498B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14289886 1986-06-20

Publications (1)

Publication Number Publication Date
ES2017498B3 true ES2017498B3 (es) 1991-02-16

Family

ID=15326163

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87305477T Expired - Lifetime ES2017498B3 (es) 1986-06-20 1987-06-19 Derivado de 2-fenilbenzoxepina.

Country Status (10)

Country Link
US (1) US4845094A (es)
EP (1) EP0250265B1 (es)
JP (1) JPH0813807B2 (es)
AT (1) ATE56211T1 (es)
AU (1) AU597671B2 (es)
CA (1) CA1277320C (es)
DE (1) DE3764724D1 (es)
DK (1) DK166676B1 (es)
ES (1) ES2017498B3 (es)
HU (1) HU206108B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
JP2851054B2 (ja) * 1989-03-15 1999-01-27 サントリー株式会社 ベンズオキセピン誘導体
FR2698873B1 (fr) * 1992-12-07 1995-02-24 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
ES2207652T3 (es) * 1994-08-05 2004-06-01 BAUSCH & LOMB INCORPORATED Dispositivo para la insercion de una lente intraocular flexible.
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CA2356422C (en) 1998-12-23 2008-09-16 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
AU776953B2 (en) 1998-12-23 2004-09-30 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
WO2000038721A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
CA2356607A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
PL348503A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
JP2003528830A (ja) 2000-03-10 2003-09-30 ファルマシア・コーポレーション テトラヒドロベンゾチエピン類の製造方法
WO2003040127A1 (en) 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
WO2016019587A1 (en) * 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593760A1 (de) * 1967-02-01 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Benz-epinderivate
DE2931399A1 (de) * 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh Neue 3-amino-1-benzoxepin-derivate und ihre salze, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3440295A1 (de) * 1984-11-05 1986-05-15 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur diastereoselektiven reduktion von 3-amino-1-benzoxepin-5(2h)-onen
US4736031A (en) * 1985-06-10 1988-04-05 Takeda Chemical Industries, Ltd. 2-(piperazinylalkyl)-1-benzothiepin, 1-benzoxepin, and 1,5-benzodioxepin derivatives

Also Published As

Publication number Publication date
US4845094A (en) 1989-07-04
JPS63107972A (ja) 1988-05-12
HUT48231A (en) 1989-05-29
DK166676B1 (da) 1993-06-28
EP0250265B1 (en) 1990-09-05
AU597671B2 (en) 1990-06-07
AU7424587A (en) 1987-12-24
EP0250265A1 (en) 1987-12-23
JPH0813807B2 (ja) 1996-02-14
DE3764724D1 (de) 1990-10-11
DK314487A (da) 1987-12-21
DK314487D0 (da) 1987-06-19
HU206108B (en) 1992-08-28
ATE56211T1 (de) 1990-09-15
CA1277320C (en) 1990-12-04

Similar Documents

Publication Publication Date Title
ES2017498B3 (es) Derivado de 2-fenilbenzoxepina.
HUT43582A (en) Process for production of derivatives of 4,5,6-substituated-n-/substituated phenil/-piramidin-amin and medical compounds containing thereof
DE3775527D1 (de) 1,5-diphenylpyrazol-3-carbonsaeurederivate zum schuetzen von kulturpflanzen.
FI871492A (fi) Menetelmä lääkeaineina käyttökelpoisten 2-tiometyyli-substituoitujen 1,4-dihydropyridiinien valmistamiseksi
PH25389A (en) Novel thiazole derivatives active on the cholinergic system, process for obtention, pharmaceutical compositions
AU577928B2 (en) Labd-14-en-11-one derivatives
PT87717A (pt) Process for preparing 2,4-thiazolidinedione derivatives
FI873350A (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
NO168654C (no) Fremgangsmaate for polymerisering av 1,3-butadien.
ES2086065T3 (es) Preparacion de tetrahidropiridinas sustituidas.
FI884660A (fi) Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
FI883759A (fi) C.12-modifierade etromycin a-derivat.
GR3017198T3 (en) Process for modification of a molecular sieve.
NO167807C (no) Analogifremgangsmaate til fremstilling av 3',4'-dinitrogensubstituerte epipodofyllotoksinglukosidderivater.
PH23992A (en) Optically active 2,3-dihydrobenzoxazine derivatives and process for preparing the same
FI891111A0 (fi) Menetelmä 1,4-dihydropyridiinijohdannaisten valmistamiseksi
IL89401A0 (en) Medicaments containing 1,4-dihydropyridine derivatives for the treatment of alcohol addiction
RO84910A (ro) Procedeu pentru prepararea unor derivati 1,1-dioxizi ai acidului 6-aminoalchilpenicilanic
GR3003638T3 (es)
FI933928A0 (fi) Heteroarenylpiperaziner, foerfarande foer framstaellning av dessa och anvaendning som laekemedel
ATE66459T1 (de) Herstellungsverfahren von trifluormethylverbindungen.
ES2033859T3 (es) Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.
ES2052812T3 (es) Un procedimiento para la preparacion de derivados de pirrolizina.
ES2039270T3 (es) Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
PT83567B (pt) Novo processo de preparacao de derivados da 2,6-piperidindiona