DE3882105T2 - Mehrzahnige Chelatbildner, basierend auf der 8-Hydroxychinolin-Einheit. - Google Patents

Mehrzahnige Chelatbildner, basierend auf der 8-Hydroxychinolin-Einheit.

Info

Publication number
DE3882105T2
DE3882105T2 DE88114864T DE3882105T DE3882105T2 DE 3882105 T2 DE3882105 T2 DE 3882105T2 DE 88114864 T DE88114864 T DE 88114864T DE 3882105 T DE3882105 T DE 3882105T DE 3882105 T2 DE3882105 T2 DE 3882105T2
Authority
DE
Germany
Prior art keywords
chelating agents
agents based
hydroxyquinoline
unit
tooth chelating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88114864T
Other languages
English (en)
Other versions
DE3882105D1 (de
Inventor
David K Johnson
Steven J Kline
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE3882105D1 publication Critical patent/DE3882105D1/de
Application granted granted Critical
Publication of DE3882105T2 publication Critical patent/DE3882105T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE88114864T 1987-09-24 1988-09-12 Mehrzahnige Chelatbildner, basierend auf der 8-Hydroxychinolin-Einheit. Expired - Fee Related DE3882105T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/100,390 US5021567A (en) 1987-09-24 1987-09-24 8-hydroxyquinoline chelating agents

Publications (2)

Publication Number Publication Date
DE3882105D1 DE3882105D1 (de) 1993-08-05
DE3882105T2 true DE3882105T2 (de) 1993-12-09

Family

ID=22279504

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88114864T Expired - Fee Related DE3882105T2 (de) 1987-09-24 1988-09-12 Mehrzahnige Chelatbildner, basierend auf der 8-Hydroxychinolin-Einheit.

Country Status (9)

Country Link
US (1) US5021567A (de)
EP (1) EP0308757B1 (de)
JP (1) JP2552714B2 (de)
KR (1) KR890005057A (de)
AT (1) ATE91126T1 (de)
AU (2) AU612407B2 (de)
CA (1) CA1336827C (de)
DE (1) DE3882105T2 (de)
ES (1) ES2058194T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ262986A (en) * 1993-02-23 1997-06-24 Merrell Dow Pharma Polyamine derivatives; use in protecting mammalian cells from the deleterious effects of ionising radiation and/or mutagenic chemicals
FR2711991B1 (fr) * 1993-11-03 1995-12-22 Centre Nat Rech Scient Composés dérivés de la 8-hydroxy-quinoléine, agents chélateurs, complexes du fer et utilisations.
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7354721B2 (en) * 2000-09-22 2008-04-08 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same
AU2002950217A0 (en) * 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
EP1704871A4 (de) * 2004-01-14 2008-08-06 Gekkeikan Kk Eisenpräparat und verwendung desselben
CA2581639C (en) * 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
FR2930558B1 (fr) * 2008-04-23 2010-06-11 Commissariat Energie Atomique Particule de silice comprenant un compose organolanthanide, procede de preparation et utilisations
EP2536691B1 (de) 2010-02-19 2017-11-22 Nordion (Canada) Inc. Bifunktionelle chelatbildende mittel
WO2013115157A1 (ja) * 2012-01-30 2013-08-08 国立大学法人奈良先端科学技術大学院大学 アミノ糖連結抗がん性貴金属錯体
KR101200049B1 (ko) * 2012-05-14 2012-11-13 한국원자력연구원 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물
US8859428B2 (en) * 2012-10-19 2014-10-14 Air Products And Chemicals, Inc. Chemical mechanical polishing (CMP) composition for shallow trench isolation (STI) applications and methods of making thereof
CN104788450A (zh) * 2015-04-23 2015-07-22 湖南华腾制药有限公司 一种吡啶并哌嗪衍生物的制备方法
JP2024060110A (ja) * 2021-02-19 2024-05-02 住友化学株式会社 放射性金属錯体及びその製造方法
JP2024045789A (ja) * 2021-02-19 2024-04-03 住友化学株式会社 化合物及び金属錯体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4017596A (en) * 1975-03-03 1977-04-12 Research Corporation Radiopharmaceutical chelates and method of external imaging
US4181654A (en) * 1978-07-24 1980-01-01 The United States Of America As Represented By The United States Department Of Energy 2,3-Dihydroxybenzoic acid amides of tetraazaalkanes and tetaaza cycloalkanes
US4543213A (en) * 1978-07-24 1985-09-24 The United States Of America As Represented By The United States Department Of Energy Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes
US4309305A (en) * 1978-07-24 1982-01-05 The United States As Represented By The United States Department Of Energy In vitro removal of actinide (IV) ions
US4421654A (en) * 1981-07-01 1983-12-20 Dow Corning Corporation Metal extraction from solution and novel compounds used therefor
US4442305A (en) * 1981-08-24 1984-04-10 The United States Of America As Represented By The United States Department Of Energy Polycatecholamide chelating agents
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
SU1081169A1 (ru) * 1982-12-13 1984-03-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова @ , @ , @ -Трис(диоксифосфорилметил)-1,4,7-триазациклононан в качестве комплексона дл селективного св зывани катионов магни ,цинка,меди,никел
US4500494A (en) * 1983-02-18 1985-02-19 Stauffer Chemical Company Microencapsulated chelating agents and their use in removing metal ions from aqueous solutions
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
EP0207097B1 (de) * 1984-12-19 1990-08-08 Ciba-Geigy Ag Neue kohlensäureester
EP0428849A3 (en) * 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
JP2922300B2 (ja) * 1990-07-06 1999-07-19 ファルマシア・アンド・アップジョン・カンパニー デフェロキサミンの調製に用いる中間体

Also Published As

Publication number Publication date
AU8579591A (en) 1991-12-19
JP2552714B2 (ja) 1996-11-13
EP0308757B1 (de) 1993-06-30
KR890005057A (ko) 1989-05-11
EP0308757A1 (de) 1989-03-29
DE3882105D1 (de) 1993-08-05
AU612407B2 (en) 1991-07-11
ATE91126T1 (de) 1993-07-15
ES2058194T3 (es) 1994-11-01
US5021567A (en) 1991-06-04
CA1336827C (en) 1995-08-29
AU2241388A (en) 1989-04-06
AU639148B2 (en) 1993-07-15
JPH01113349A (ja) 1989-05-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee