DE3874920T2 - Benzimidazol-2-one-derivate, deren salze, verfahren und zwischenprodukte zu deren herstellung, deren anwendung als arzneimittel und sie enthaltende zusammensetzungen. - Google Patents

Benzimidazol-2-one-derivate, deren salze, verfahren und zwischenprodukte zu deren herstellung, deren anwendung als arzneimittel und sie enthaltende zusammensetzungen.

Info

Publication number
DE3874920T2
DE3874920T2 DE8888400312T DE3874920T DE3874920T2 DE 3874920 T2 DE3874920 T2 DE 3874920T2 DE 8888400312 T DE8888400312 T DE 8888400312T DE 3874920 T DE3874920 T DE 3874920T DE 3874920 T2 DE3874920 T2 DE 3874920T2
Authority
DE
Germany
Prior art keywords
carbon atoms
salts
benzimidazole
intermediates
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888400312T
Other languages
English (en)
Other versions
DE3874920D1 (de
Inventor
Constantin Agouridas
Patrick Fauveau
Gilles Hamon
Lucien Nedelec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3874920D1 publication Critical patent/DE3874920D1/de
Publication of DE3874920T2 publication Critical patent/DE3874920T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE8888400312T 1987-02-13 1988-02-11 Benzimidazol-2-one-derivate, deren salze, verfahren und zwischenprodukte zu deren herstellung, deren anwendung als arzneimittel und sie enthaltende zusammensetzungen. Expired - Fee Related DE3874920T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8701836A FR2610929B1 (fr) 1987-02-13 1987-02-13 Derives de la benzimidazol-2-one, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires

Publications (2)

Publication Number Publication Date
DE3874920D1 DE3874920D1 (de) 1992-11-05
DE3874920T2 true DE3874920T2 (de) 1993-05-13

Family

ID=9347894

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888400312T Expired - Fee Related DE3874920T2 (de) 1987-02-13 1988-02-11 Benzimidazol-2-one-derivate, deren salze, verfahren und zwischenprodukte zu deren herstellung, deren anwendung als arzneimittel und sie enthaltende zusammensetzungen.

Country Status (9)

Country Link
US (1) US4831043A (de)
EP (1) EP0282373B1 (de)
JP (1) JP2651917B2 (de)
AT (1) ATE81125T1 (de)
CA (1) CA1308721C (de)
DE (1) DE3874920T2 (de)
ES (1) ES2043861T3 (de)
FR (1) FR2610929B1 (de)
GR (1) GR3006136T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
WO1997016186A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Muscarine agonists
AU2003244160A1 (en) * 2002-06-25 2004-01-06 Sumitomo Pharmaceuticals Co., Ltd. Novel benzoxazolinone derivative
CN109020923A (zh) * 2017-06-12 2018-12-18 上海百灵医药科技有限公司 一种氟班色林中间体的制备方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458549A1 (fr) * 1979-06-12 1981-01-02 Roussel Uclaf Nouveaux derives de l'indole, leur procede de preparation et leur application comme medicaments
FR2510111A1 (fr) * 1981-07-24 1983-01-28 Roussel Uclaf Nouveaux derives du piperidin-3-yl indole, leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2510112A1 (fr) * 1981-07-24 1983-01-28 Roussel Uclaf Nouveaux derives du 2-oxo-pyrid-3-yl ou piperidin-3-yl indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
EP0181793B1 (de) * 1984-10-16 1988-07-27 Synthelabo Piperidinderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung
FR2578846B1 (fr) * 1985-03-12 1987-05-22 Roussel Uclaf Derives du 7-hydroxy indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires

Also Published As

Publication number Publication date
ATE81125T1 (de) 1992-10-15
EP0282373B1 (de) 1992-09-30
JP2651917B2 (ja) 1997-09-10
DE3874920D1 (de) 1992-11-05
FR2610929B1 (fr) 1989-06-23
GR3006136T3 (de) 1993-06-21
EP0282373A1 (de) 1988-09-14
JPS63203680A (ja) 1988-08-23
FR2610929A1 (fr) 1988-08-19
US4831043A (en) 1989-05-16
CA1308721C (fr) 1992-10-13
ES2043861T3 (es) 1994-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HOECHST MARION ROUSSEL, PUTEAUX, FR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY CEDEX, FR

8339 Ceased/non-payment of the annual fee