DE3856335D1 - Peptid zur beschleunigung der wirkung des proteins-c mit thrombin - Google Patents

Peptid zur beschleunigung der wirkung des proteins-c mit thrombin

Info

Publication number
DE3856335D1
DE3856335D1 DE3856335T DE3856335T DE3856335D1 DE 3856335 D1 DE3856335 D1 DE 3856335D1 DE 3856335 T DE3856335 T DE 3856335T DE 3856335 T DE3856335 T DE 3856335T DE 3856335 D1 DE3856335 D1 DE 3856335D1
Authority
DE
Germany
Prior art keywords
peptide
thrombin
protein
accelerating
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3856335T
Other languages
English (en)
Other versions
DE3856335T2 (de
Inventor
Shuji Yamamoto
Koji Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27547577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3856335(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of DE3856335D1 publication Critical patent/DE3856335D1/de
Application granted granted Critical
Publication of DE3856335T2 publication Critical patent/DE3856335T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3856335T 1987-01-08 1988-01-08 Peptid zur beschleunigung der wirkung des proteins-c mit thrombin Expired - Lifetime DE3856335T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP106687 1987-01-08
JP106587 1987-01-08
JP14408187 1987-06-11
JP30587887 1987-12-04
JP30587687 1987-12-04
JP30587787 1987-12-04
PCT/JP1988/000011 WO1988005053A1 (en) 1987-01-08 1988-01-08 Peptide functioning to accelerate activation of protein c with thrombin

Publications (2)

Publication Number Publication Date
DE3856335D1 true DE3856335D1 (de) 1999-07-01
DE3856335T2 DE3856335T2 (de) 2000-01-27

Family

ID=27547577

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3856335T Expired - Lifetime DE3856335T2 (de) 1987-01-08 1988-01-08 Peptid zur beschleunigung der wirkung des proteins-c mit thrombin

Country Status (6)

Country Link
US (1) US6034060A (de)
EP (4) EP0816493A1 (de)
AT (1) ATE180496T1 (de)
DE (1) DE3856335T2 (de)
HK (1) HK1002591A1 (de)
WO (1) WO1988005053A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
EP0445304A4 (en) * 1989-09-25 1992-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Isolated, physiologically active human thrombomodulin polypeptide
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
KR930008093B1 (ko) * 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
CA2156255C (en) * 1993-12-17 2008-02-05 Yasuyuki Kunihiro Soluble thrombomodulin-containing composition
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
EP0763360B1 (de) * 1994-04-20 2005-02-16 Asahi Kasei Pharma Corporation Verwendung von thrombomodulin gegen lebererkrankungen
WO1998029453A1 (fr) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Medicaments diriges vers la membrane cellulaire
ES2281137T3 (es) 1997-10-15 2007-09-16 Asahi Kasei Pharma Corporation Metodo para mantener la calidad de un preparado de inyeccion acuoso de trombomodulina durante su almacenamiento y transporte.
CN1314915A (zh) * 1998-06-30 2001-09-26 持田制药株式会社 新的糖链连接的凝血调节蛋白样肽
EP1475098B1 (de) * 2002-01-18 2015-08-05 Asahi Kasei Pharma Corporation Hochkonzentrierte zubereitung von löslichem thrombomodulin
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
MX2009003384A (es) * 2006-10-06 2009-04-08 Asahi Kasei Pharma Corp Agente terapeutico y/o de mejoramiento para la coagulacion intravascular diseminada.
NZ579873A (en) * 2007-03-23 2011-11-25 Asahi Kasei Pharma Corp Method for producing soluble thrombomodulin of high purity
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US20120270789A1 (en) 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
CA2796452C (en) 2010-04-30 2017-12-05 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin and method for producing same
CN103037893A (zh) 2010-06-14 2013-04-10 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
US8772239B2 (en) 2011-11-15 2014-07-08 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
HUE045997T2 (hu) * 2012-05-31 2020-01-28 Univ Kinki Hatóanyag rákellenes szer által okozott perifériás neuropátiás fájdalom megelõzésére és/vagy kezelésére
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
CN111295094A (zh) 2017-10-09 2020-06-16 泰尔茂比司特生物技术有限公司 冻干容器及使用冻干容器的方法
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
JP2022525742A (ja) 2019-03-14 2022-05-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥用ローディングトレイ組立体及びシステム
CN117683081A (zh) * 2021-09-24 2024-03-12 江西康之康中药科技有限公司 一种降血压肽及其在降血压制品上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
EP0239644A4 (de) * 1985-06-28 1987-10-27 Asahi Chemical Ind Neue physiologisch aktive mittel mit blutkoagulierungsregelnder wirkung.
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
US5583102A (en) * 1993-12-03 1996-12-10 University Of Iowa Research Foundation Human thrombomodulin in wound healing

Also Published As

Publication number Publication date
EP0816495A1 (de) 1998-01-07
ATE180496T1 (de) 1999-06-15
EP0816493A1 (de) 1998-01-07
US6034060A (en) 2000-03-07
EP0312598A4 (de) 1989-05-16
EP0312598A1 (de) 1989-04-26
EP0816494A1 (de) 1998-01-07
EP0312598B1 (de) 1999-05-26
DE3856335T2 (de) 2000-01-27
WO1988005053A1 (en) 1988-07-14
HK1002591A1 (en) 1998-09-04
JPH11236335A (ja) 1999-08-31

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Legal Events

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOETERS & LIECK, 81541 MUENCHEN