DE3815473A1 - Wirkstoff-system fuer den lipidaustausch mit zielstrukturen - Google Patents

Wirkstoff-system fuer den lipidaustausch mit zielstrukturen

Info

Publication number
DE3815473A1
DE3815473A1 DE3815473A DE3815473A DE3815473A1 DE 3815473 A1 DE3815473 A1 DE 3815473A1 DE 3815473 A DE3815473 A DE 3815473A DE 3815473 A DE3815473 A DE 3815473A DE 3815473 A1 DE3815473 A1 DE 3815473A1
Authority
DE
Germany
Prior art keywords
lipid
active ingredient
ingredient system
drug
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE3815473A
Other languages
German (de)
English (en)
Other versions
DE3815473C2 (https=
Inventor
Karl Heinz Prof Dr Dr Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE3815473A priority Critical patent/DE3815473A1/de
Priority to FR898905867A priority patent/FR2631236B1/fr
Priority to JP1112846A priority patent/JPH0214736A/ja
Publication of DE3815473A1 publication Critical patent/DE3815473A1/de
Application granted granted Critical
Publication of DE3815473C2 publication Critical patent/DE3815473C2/de
Priority to US07/744,308 priority patent/US6077529A/en
Priority to US08/474,460 priority patent/US5776470A/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
DE3815473A 1988-05-06 1988-05-06 Wirkstoff-system fuer den lipidaustausch mit zielstrukturen Granted DE3815473A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE3815473A DE3815473A1 (de) 1988-05-06 1988-05-06 Wirkstoff-system fuer den lipidaustausch mit zielstrukturen
FR898905867A FR2631236B1 (fr) 1988-05-06 1989-05-03 Systeme agent actif pour l'echange de lipides avec des structures cibles, procede pour sa preparation et son utilisation et produits le contenant
JP1112846A JPH0214736A (ja) 1988-05-06 1989-05-06 標的構造との脂質交換のための作用物質系
US07/744,308 US6077529A (en) 1988-05-06 1991-08-13 Active ingredient system and method of manufacture thereof for transfer of lipophilic and amphiphilic components to target structures
US08/474,460 US5776470A (en) 1988-05-06 1995-06-07 Method of using lipid transfer proteins and lipids to reconstitute membranes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3815473A DE3815473A1 (de) 1988-05-06 1988-05-06 Wirkstoff-system fuer den lipidaustausch mit zielstrukturen

Publications (2)

Publication Number Publication Date
DE3815473A1 true DE3815473A1 (de) 1989-11-16
DE3815473C2 DE3815473C2 (https=) 1991-04-25

Family

ID=6353793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3815473A Granted DE3815473A1 (de) 1988-05-06 1988-05-06 Wirkstoff-system fuer den lipidaustausch mit zielstrukturen

Country Status (3)

Country Link
JP (1) JPH0214736A (https=)
DE (1) DE3815473A1 (https=)
FR (1) FR2631236B1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461559A3 (en) * 1990-06-12 1992-07-08 B. Braun Melsungen Ag Non active substance containing liposomes for the treatment of atherosclerosis
WO1993009805A1 (fr) * 1991-11-15 1993-05-27 Laboratoires Inocosm Composition lipidique polaire d'origine vegetale
WO1994018240A1 (fr) * 1993-02-11 1994-08-18 Institut National De La Recherche Agronomique-Inra Proteines de champignons filamenteux capables de realiser la fixation et le transport de lipides, leur procede d'obtention et leurs applications
US5817646A (en) * 1991-11-15 1998-10-06 Laboratoires Inocosm Polar lipid composition of plant origin
WO1998056351A1 (fr) * 1997-06-11 1998-12-17 Lipogel Compositions pulverulentes de liposomes unilamellaires
WO2007059836A3 (de) * 2005-11-28 2007-10-18 Merz Pharma Gmbh & Co Kgaa Zusammensetzungen, enthaltend proteine zum transfer / recycling strukturell veränderter lipide sowie deren anwendungen
WO2011006616A2 (de) 2009-07-15 2011-01-20 Merz Pharma Gmbh & Co. Kgaa FLÜSSIGE ODER FLIEßFÄHIGE PROTEOSOMENBILDENDE BADE- UND DUSCH-KONZENTRATE, GALENISCHE ANWENDUNGSPRODUKTE HIERVON UND DEREN VERWENDUNG

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664500B1 (fr) * 1990-07-13 1994-10-28 Lille Ii Universite Droit Sant Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile, lipoproteine modifiee ainsi obtenue et composition pharmaceutique ou cosmetique la contenant.
FR2673841B1 (fr) * 1991-03-12 1995-03-10 Sanofi Elf Composition cosmetique a base de proteine de transfert.
FR2911779B1 (fr) * 2007-01-30 2009-04-24 Lvmh Rech Composition contenant un extrait d'ambre

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004880A1 (en) * 1984-04-19 1985-11-07 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004880A1 (en) * 1984-04-19 1985-11-07 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemistry and Physics of Lipids, 38, S. 79, 1985, Elsevier, Scientific Publishers Ireland Ltd. *
Lexikon der Biologie, Bd. 5, Herder, Freiburg, Basel, Wien Liposomen, Proteine insbes. Trans- portproteine, 1985 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461559A3 (en) * 1990-06-12 1992-07-08 B. Braun Melsungen Ag Non active substance containing liposomes for the treatment of atherosclerosis
WO1993009805A1 (fr) * 1991-11-15 1993-05-27 Laboratoires Inocosm Composition lipidique polaire d'origine vegetale
US5817646A (en) * 1991-11-15 1998-10-06 Laboratoires Inocosm Polar lipid composition of plant origin
WO1994018240A1 (fr) * 1993-02-11 1994-08-18 Institut National De La Recherche Agronomique-Inra Proteines de champignons filamenteux capables de realiser la fixation et le transport de lipides, leur procede d'obtention et leurs applications
FR2701481A1 (fr) * 1993-02-11 1994-08-19 Agronomique Inst Nat Rech Protéines de champignons filamenteux capables de réaliser la fixation et le transport de lipides, leur procédé d'obtention et leurs applications.
US5717070A (en) * 1993-02-11 1998-02-10 Institut National De La Recherche Agronomique-Inra Filamentous fungus proteins for binding and transporting lipids, method for preparing them and their applications
WO1998056351A1 (fr) * 1997-06-11 1998-12-17 Lipogel Compositions pulverulentes de liposomes unilamellaires
FR2764507A1 (fr) * 1997-06-11 1998-12-18 Lipogel Sarl Compositions pulverulentes de liposomes unilamellaires, leur procede de preparation et leurs applications comme complements nutritionnels et comme complements nutritionnels et comme medicaments
US6331315B1 (en) 1997-06-11 2001-12-18 Lipogel Powder compositions of unilamellar liposomes
WO2007059836A3 (de) * 2005-11-28 2007-10-18 Merz Pharma Gmbh & Co Kgaa Zusammensetzungen, enthaltend proteine zum transfer / recycling strukturell veränderter lipide sowie deren anwendungen
RU2442563C2 (ru) * 2005-11-28 2012-02-20 Мерц Фарма Гмбх Унд Ко. Кгаа Композиции, содержащие белки для переноса/рециркуляции структурно модифицированных липидов, и их применение
WO2011006616A2 (de) 2009-07-15 2011-01-20 Merz Pharma Gmbh & Co. Kgaa FLÜSSIGE ODER FLIEßFÄHIGE PROTEOSOMENBILDENDE BADE- UND DUSCH-KONZENTRATE, GALENISCHE ANWENDUNGSPRODUKTE HIERVON UND DEREN VERWENDUNG
DE102009033109A1 (de) 2009-07-15 2011-02-03 Merz Pharma Gmbh & Co. Kgaa Flüssige oder fließfähige proteosomenbildende Bade- und Dusch-Konzentrate, galenische Anwendungsprodukte hiervon und deren Verwendung
WO2011006616A3 (de) * 2009-07-15 2011-12-29 Merz Pharma Gmbh & Co. Kgaa FLÜSSIGE ODER FLIEßFÄHIGE PROTEOSOMENBILDENDE BADE- UND DUSCH-KONZENTRATE, GALENISCHE ANWENDUNGSPRODUKTE HIERVON UND DEREN VERWENDUNG

Also Published As

Publication number Publication date
FR2631236A1 (fr) 1989-11-17
FR2631236B1 (fr) 1992-08-07
DE3815473C2 (https=) 1991-04-25
JPH0214736A (ja) 1990-01-18

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: SCHMIDT, KARL HEINZ, PROF. DR. DR., 7413 GOMARINGE

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERZ PHARMA GMBH & CO. KGAA, 60318 FRANKFURT, DE

8381 Inventor (new situation)

Inventor name: SCHMIDT, KARL HEINZ, PROF. DR. DR., 72810 GOMARING