DE3780357T2 - Plasminogen-aktivator und thrombolytische zusammensetzung. - Google Patents

Plasminogen-aktivator und thrombolytische zusammensetzung.

Info

Publication number
DE3780357T2
DE3780357T2 DE8787200909T DE3780357T DE3780357T2 DE 3780357 T2 DE3780357 T2 DE 3780357T2 DE 8787200909 T DE8787200909 T DE 8787200909T DE 3780357 T DE3780357 T DE 3780357T DE 3780357 T2 DE3780357 T2 DE 3780357T2
Authority
DE
Germany
Prior art keywords
scu
plasminogen activator
molecular weight
plasminogen
urokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787200909T
Other languages
German (de)
English (en)
Other versions
DE3780357D1 (de
Inventor
Desire Jose Collen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KU Leuven
Original Assignee
KU Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KU Leuven filed Critical KU Leuven
Publication of DE3780357D1 publication Critical patent/DE3780357D1/de
Application granted granted Critical
Publication of DE3780357T2 publication Critical patent/DE3780357T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8787200909T 1986-05-15 1987-05-15 Plasminogen-aktivator und thrombolytische zusammensetzung. Expired - Lifetime DE3780357T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8601240A NL8601240A (nl) 1986-05-15 1986-05-15 Plasminogeenactivator en trombolytisch geneesmiddel.

Publications (2)

Publication Number Publication Date
DE3780357D1 DE3780357D1 (de) 1992-08-20
DE3780357T2 true DE3780357T2 (de) 1992-12-17

Family

ID=19848019

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787200909T Expired - Lifetime DE3780357T2 (de) 1986-05-15 1987-05-15 Plasminogen-aktivator und thrombolytische zusammensetzung.

Country Status (7)

Country Link
EP (1) EP0247674B1 (enExample)
JP (1) JPS62285784A (enExample)
AT (1) ATE78292T1 (enExample)
DE (1) DE3780357T2 (enExample)
ES (1) ES2033295T3 (enExample)
GR (1) GR3005408T3 (enExample)
NL (1) NL8601240A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2354588A (en) * 1987-10-09 1989-04-20 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
DE3735917A1 (de) * 1987-10-23 1989-05-03 Basf Ag Neue polypeptide, ihre herstellung und verwendung
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68366A (en) * 1982-04-15 1990-08-31 Genentech Inc Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen

Also Published As

Publication number Publication date
EP0247674A1 (en) 1987-12-02
DE3780357D1 (de) 1992-08-20
NL8601240A (nl) 1987-12-01
EP0247674B1 (en) 1992-07-15
JPS62285784A (ja) 1987-12-11
GR3005408T3 (enExample) 1993-05-24
ES2033295T3 (es) 1993-03-16
ATE78292T1 (de) 1992-08-15

Similar Documents

Publication Publication Date Title
DE69131292T2 (de) Antikoagulierende proteine
DE69004966T2 (de) Antikoagulierendes protein.
DE69032600T3 (de) Rekombinanter abkömmling des menschlichen faktors iii
DE69333727T2 (de) Protein-C-Derivat
DE3789870T2 (de) Von thrombin abstammende polypeptid-zusammensetzungen und methoden für ihre benutzung.
DE3586402T3 (de) Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung.
DE3382760T2 (de) Herstellung von funktionellen menschlichen Urokinasepolypeptiden.
EP0382174B1 (de) Gewebs-Plasminogenaktivator-Derivat
DE69126205T2 (de) Oxidationsresistente analoga des thrombomodulins
DE69006851T2 (de) Blutgerinnungshemmende zusammensetzungen aus faktor xa.
DE3689943T2 (de) Degradierte Spezies eines Gewebeplasminogenaktivators, pharmazeutische Zubereitung und Verfahren zur Herstellung derselben.
DE68923556T2 (de) Säureempfindliche subeinheit eines insulinähnlichen wachstumfaktors-bindeprotein-komplexes.
DE68921979T2 (de) Antikörper für die antilymphozyten-antikörpertherapie.
DD258999A5 (de) Verfahren zur Herstellung von Human-Gewebeplasminogen-Aktivator
DE69032029T2 (de) Hybrides protein c
DE69726571T2 (de) Rekombinantes humanes Erythropoietin mit vorteilhaftem Glykosylierungsmuster
DE69737500T2 (de) Gereinigte Multimerase
EP1015020A1 (de) Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
EP0669394B1 (de) Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
DE69621591T2 (de) Medikament welches Protein C aktivierendes Peptid enthält
DE3750664T2 (de) Throminbindende Substanz und Verfahren zu ihrer Herstellung.
DE3486023T2 (de) Verfahren zur herstellung von urokinase zymogen.
DE3855874T2 (de) Neue variante von menschlichem gewebeplasminogenaktivator
DE69321134T2 (de) Plasminogen-derivate die durch thrombin aktivierbar sind
WO2000049047A1 (de) VERFAHREN ZUR HERSTELLUNG EINER vWF-PRÄPARATION

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee