ATE78292T1 - Plasminogen-aktivator und thrombolytische zusammensetzung. - Google Patents

Plasminogen-aktivator und thrombolytische zusammensetzung.

Info

Publication number
ATE78292T1
ATE78292T1 AT87200909T AT87200909T ATE78292T1 AT E78292 T1 ATE78292 T1 AT E78292T1 AT 87200909 T AT87200909 T AT 87200909T AT 87200909 T AT87200909 T AT 87200909T AT E78292 T1 ATE78292 T1 AT E78292T1
Authority
AT
Austria
Prior art keywords
plasminogen activator
gln
lys
blood
thrombolytic
Prior art date
Application number
AT87200909T
Other languages
German (de)
English (en)
Inventor
Desire Jose Collen
Original Assignee
Leuven Res & Dev Vzw
Desire Jose Collen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven Res & Dev Vzw, Desire Jose Collen filed Critical Leuven Res & Dev Vzw
Application granted granted Critical
Publication of ATE78292T1 publication Critical patent/ATE78292T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87200909T 1986-05-15 1987-05-15 Plasminogen-aktivator und thrombolytische zusammensetzung. ATE78292T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8601240A NL8601240A (nl) 1986-05-15 1986-05-15 Plasminogeenactivator en trombolytisch geneesmiddel.
EP87200909A EP0247674B1 (en) 1986-05-15 1987-05-15 Plasminogen activator and thrombolytic composition

Publications (1)

Publication Number Publication Date
ATE78292T1 true ATE78292T1 (de) 1992-08-15

Family

ID=19848019

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87200909T ATE78292T1 (de) 1986-05-15 1987-05-15 Plasminogen-aktivator und thrombolytische zusammensetzung.

Country Status (7)

Country Link
EP (1) EP0247674B1 (enExample)
JP (1) JPS62285784A (enExample)
AT (1) ATE78292T1 (enExample)
DE (1) DE3780357T2 (enExample)
ES (1) ES2033295T3 (enExample)
GR (1) GR3005408T3 (enExample)
NL (1) NL8601240A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2354588A (en) * 1987-10-09 1989-04-20 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
DE3735917A1 (de) * 1987-10-23 1989-05-03 Basf Ag Neue polypeptide, ihre herstellung und verwendung
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
GB8919803D0 (en) * 1989-09-01 1989-10-18 Ciba Geigy Pharmaceutical compositions
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68366A (en) * 1982-04-15 1990-08-31 Genentech Inc Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen

Also Published As

Publication number Publication date
EP0247674A1 (en) 1987-12-02
DE3780357D1 (de) 1992-08-20
DE3780357T2 (de) 1992-12-17
NL8601240A (nl) 1987-12-01
EP0247674B1 (en) 1992-07-15
JPS62285784A (ja) 1987-12-11
GR3005408T3 (enExample) 1993-05-24
ES2033295T3 (es) 1993-03-16

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